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D

Douglas MacDonald

royal free london nhs foundation trust
H指数:25
被引数:2,688

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Expanded adaptive NKG2C+ NK cells exhibit potent ADCC and functional responses against HBV-infected hepatoma cell lines

扩增的适应性NKG2C+ NK细胞对HBV感染的肝癌细胞系表现出强大的ADCC和功能反应。

Cytotherapy
IF3.2
2025-10-250
OAAI
Jonida Kokiçi; Helena Arellano-Ballestero; Benjamin Hammond; Anucha Preechanukul; Noshin Hussain; Kelly da Costa; Jessica Davies; Sadiyah Mukhtar; Thomas Fernandez; Sabine Kinloch; Fiona M Burns; Patrick Kennedy; Douglas MacDonald; Mala K Maini; Upkar S Gill; Alan Xiaodong Zhuang; Mark W Lowdell; Karl-Johan Malmberg; Ebba Sohlberg; Dimitra Peppa
CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo

基于全人源T细胞受体模拟抗体的CAR T细胞在体内表现出强大的抗肿瘤活性。

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2025-03-260
PRE
Salzler, Robert; Dilillo, David J.; Saotome, Kei; Bray, Kevin; Mohrs, Katja; Hwang, Haun; Cygan, Kamil J.; Shah, Darshit; Rye-Weller, Anna; Kundu, Kunal; Badithe, Ashok; Zhang, Xiaoqin; Garnova, Elena; Torres, Marcela; Dhanik, Ankur; Babb, Robert; Delfino, Frank J.; Thwaites, Courtney; Dudgeon, Drew; Moore, Michael J.; Meagher, Thomas Craig; Decker, Corinne E.; Owczarek, Tomasz; Gleason, John A.; Yang, Xiaoran; Suh, David; Lee, Wen-Yi; Welsh, Richard; Macdonald, Douglas; Hansen, Johanna; Guo, Chunguang; Kirshner, Jessica R.; Thurston, Gavin; Huang, Tammy; Franklin, Matthew C.; Yancopoulos, George D.; Lin, John C.; Macdonald, Lynn E.; Murphy, Andrew J.; Chen, Gang; Olsen, Olav; Olson, William C.
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

通过CD3亲和力调节产生具有细胞因子释放和生物分布的分化特征的T细胞重定向双特异性抗体

SCIENTIFIC REPORTS
IF3.9
2021-07-1364
OAAI
Haber, Lauric; Olson, Kara; Kelly, Marcus P.; Crawford, Alison; DiLillo, David J.; Tavare, Richard; Ullman, Erica; Mao, Shu; Canova, Lauren; Sineshchekova, Olga; Finney, Jennifer; Pawashe, Arpita; Patel, Supriya; McKay, Ryan; Rizvi, Sahar; Damko, Ermelinda; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; D'Orvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Chen, Ya Ping; Thwaites, Courtney; Dudgeon, Drew; Bray, Kevin; Rafique, Ashique; Huang, Tammy; Delfino, Frank; Hermann, Aynur; Kirshner, Jessica R.; Retter, Marc W.; Babb, Robert; MacDonald, Douglas; Chen, Gang; Olson, William C.; Thurston, Gavin; Davis, Samuel; Lin, John C.; Smith, Eric
Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-06-2466
PREAI
Waite, Janelle C.; Wang, Bei; Haber, Lauric; Hermann, Aynur; Ullman, Erica; Ye, Xuan; Dudgeon, Drew; Slim, Rabih; Ajithdoss, Dharani K.; Godin, Stephen J.; Ramos, Ilyssa; Wu, Qi; Oswald, Erin; Poon, Patrick; Golubov, Jacquelynn; Grote, Devon; Stella, Jennifer; Pawashe, Arpita; Finney, Jennifer; Herlihy, Evan; Ahmed, Hassan; Kamat, Vishal; Dorvilliers, Amanda; Navarro, Elizabeth; Xiao, Jenny; Kim, Julie; Yang, Shao Ning; Warsaw, Jacqueline; Lett, Clarissa; Canova, Lauren; Schulenburg, Teresa; Foster, Randi; Krueger, Pamela; Garnova, Elena; Rafique, Ashique; Babb, Robert; Chen, Gang; Oristian, Nicole Stokes; Siao, Chia-Jen; Daly, Christopher; Gurer, Cagan; Martin, Joel; Macdonald, Lynn; MacDonald, Douglas; Poueymirou, William; Smith, Eric; Lowy, Israel; Thurston, Gavin; Olson, William; Lin, John C.; Sleeman, Matthew A.; Yancopoulos, George D.; Murphy, Andrew J.; Skokos, Dimitris
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

一类增强CD3-bispecific抗体抗肿瘤活性的共刺激CD28-bispecific抗体

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-01-0894
OAAI
Skokos, Dimitris; Waite, Janelle C.; Haber, Lauric; Crawford, Alison; Hermann, Aynur; Ullman, Erica; Slim, Rabih; Godin, Stephen; Ajithdoss, Dharani; Ye, Xuan; Wang, Bei; Wu, Qi; Ramos, Ilyssa; Pawashe, Arpita; Canova, Lauren; Vazzana, Kristin; Ram, Priyanka; Herlihy, Evan; Ahmed, Hassan; Oswald, Erin; Golubov, Jacquelynn; Poon, Patrick; Havel, Lauren; Chiu, Danica; Lazo, Miguel; Provoncha, Kathleen; Yu, Kevin; Kim, Julie; Warsaw, Jacqueline J.; Oristian, Nicole Stokes; Siao, Chia-Jen; Dudgeon, Drew; Huang, Tammy; Potocky, Terra; Martin, Joel; MacDonald, Douglas; Oyejide, Adelekan; Rafique, Ashique; Poueymirou, William; Kirshner, Jessica R.; Smith, Eric; Olson, William; Lin, John; Thurston, Gavin; Sleeman, Matthew A.; Murphy, Andrew J.; Yancopoulos, George D.
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-12-264
OAAI
Macdonald, Lynn E.; Meagher, Karoline A.; Franklin, Matthew C.; Levenkova, Natasha; Hansen, Johanna; Badithe, Ashok T.; Zhong, Maggie; Krueger, Pamela; Rafique, Ashique; Tu, Naxin; Shevchuk, James; Wadhwa, Saurabh; Ehrlich, George; Bautista, Joannie; Grant, Craig; Esau, Lakeisha; Poueymirou, William T.; Auerbach, Wojtek; Morton, Lori; Babb, Robert; Chen, Gang; Huang, Tammy; MacDonald, Douglas; Graham, Kenneth; Gurer, Cagan; Voronina, Vera A.; McWhirter, John R.; Guo, Chunguang; Yancopoulos, George D.; Murphy, Andrew J.
Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3-Knockin Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-11-0164
OAAI
Burova, Elena; Hermann, Aynur; Dai, Jie; Ullman, Erica; Halasz, Gabor; Potocky, Terra; Hong, Seongwon; Liu, Matt; Allbritton, Omaira; Woodruff, Amy; Pei, Jerry; Rafique, Ashique; Poueymirou, William; Martin, Joel; MacDonald, Douglas; Olson, William C.; Murphy, Andrew; Ioffe, Ella; Thurston, Gavin; Mohrs, Markus
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2019-06-19100
OAAI
Crawford, Alison; Haber, Lauric; Kelly, Marcus P.; Vazzana, Kristin; Canova, Lauren; Ram, Priyanka; Pawashe, Arpita; Finney, Jennifer; Jalal, Sumreen; Chiu, Danica; Colleton, Curtis A.; Garnova, Elena; Makonnen, Sosina; Hickey, Carlos; Krueger, Pamela; DelFino, Frank; Potocky, Terra; Kuhnert, Jessica; Godin, Stephen; Retter, Marc W.; Duramad, Paurene; MacDonald, Douglas; Olson, William C.; Fairhurst, Jeanette; Huang, Tammy; Martin, Joel; Lin, John C.; Smith, Eric; Thurston, Gavin; Kirshner, Jessica R.
Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype
SCIENCE IMMUNOLOGY
IF16.3
2018-11-30138
OA
Wang, Bei; Zhang, Wen; Jankovic, Vladimir; Golubov, Jacquelynn; Poon, Patrick; Oswald, Erin M.; Gurer, Cagan; Wei, Joyce; Ramos, Ilyssa; Wu, Qi; Waite, Janelle; Ni, Min; Adler, Christina; Wei, Yi; Macdonald, Lynn; Rowlands, Tracey; Brydges, Susannah; Siao, Jean; Poueymirou, William; MacDonald, Douglas; Yancopoulos, George D.; Sleeman, Matthew A.; Murphy, Andrew J.; Skokos, Dimitris
Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-05-02125
OAAI
Burova, Elena; Hermann, Aynur; Waite, Janelle; Potocky, Terra; Lai, Venus; Hong, Seongwon; Liu, Matt; Allbritton, Omaira; Woodruff, Amy; Wu, Qi; D'Orvilliers, Amanda; Garnova, Elena; Rafique, Ashique; Poueymirou, William; Martin, Joel; Huang, Tammy; Skokos, Dimitris; Kantrowitz, Joel; Popke, Jon; Mohrs, Markus; MacDonald, Douglas; Ioffe, Ella; Olson, William; Lowy, Israel; Murphy, Andrew; Thurston, Gavin
Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes
ANGIOGENESIS
IF9.2
2016-05-2735
OAAI
MacDonald, Douglas A.; Martin, Joel; Muthusamy, Kathir K.; Luo, Jiann-Kae; Pyles, Erica; Rafique, Ashique; Huang, Tammy; Potocky, Terra; Liu, Yang; Cao, Jingtai; Bono, Francoise; Delesque, Nathalie; Savi, Pierre; Francis, John; Amirkhosravi, Ali; Meyer, Todd; Romano, Carmelo; Glinka, Meredith; Yancopoulos, George D.; Stahl, Neil; Wiegand, Stanley J.; Papadopoulos, Nicholas
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys
SCIENTIFIC REPORTS
IF3.9
2015-12-11195
OAAI
Smith, Eric J.; Olson, Kara; Haber, Lauric J.; Varghese, Bindu; Duramad, Paurene; Tustian, Andrew D.; Oyejide, Adelekan; Kirshner, Jessica R.; Canova, Lauren; Menon, Jayanthi; Principio, Jennifer; MacDonald, Douglas; Kantrowitz, Joel; Papadopoulos, Nicholas; Stahl, Neil; Yancopoulos, George D.; Thurston, Gavin; Davis, Samuel

研究方向

暂未获取到该数据
G
Gavin Thurston
H 指数:79论文数:489被引数:3.0万
W
William C. Olson
H 指数:58论文数:379被引数:1.4万
A
Ashique Rafique
H 指数:33论文数:184被引数:7,214
A
Andrew Murphy
H 指数:81论文数:457被引数:3.1万
T
Tammy Huang
H 指数:22论文数:106被引数:6,667
W
William Poueymirou
H 指数:29论文数:93被引数:1.0万
G
George D. Yancopoulos
H 指数:203论文数:945被引数:16.4万
J
Jessica R. Kirshner
H 指数:22论文数:111被引数:3,517
J
Joel Martin
H 指数:20论文数:40被引数:3,049
E
Ella Ioffe
H 指数:18论文数:85被引数:4,922