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T

Tammy Huang

regeneron
H指数:22
被引数:6,667

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CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo

基于全人源T细胞受体模拟抗体的CAR T细胞在体内表现出强大的抗肿瘤活性。

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2025-03-260
PRE
Salzler, Robert; Dilillo, David J.; Saotome, Kei; Bray, Kevin; Mohrs, Katja; Hwang, Haun; Cygan, Kamil J.; Shah, Darshit; Rye-Weller, Anna; Kundu, Kunal; Badithe, Ashok; Zhang, Xiaoqin; Garnova, Elena; Torres, Marcela; Dhanik, Ankur; Babb, Robert; Delfino, Frank J.; Thwaites, Courtney; Dudgeon, Drew; Moore, Michael J.; Meagher, Thomas Craig; Decker, Corinne E.; Owczarek, Tomasz; Gleason, John A.; Yang, Xiaoran; Suh, David; Lee, Wen-Yi; Welsh, Richard; Macdonald, Douglas; Hansen, Johanna; Guo, Chunguang; Kirshner, Jessica R.; Thurston, Gavin; Huang, Tammy; Franklin, Matthew C.; Yancopoulos, George D.; Lin, John C.; Macdonald, Lynn E.; Murphy, Andrew J.; Chen, Gang; Olsen, Olav; Olson, William C.
A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Ra strengthens T cell-mediated anti-tumor therapies
CELL REPORTS MEDICINE
IF10.6
2024-10-010
OAAI
Wu, Jiaxi; Bloch, Nicolin; Chang, Aaron Y.; Bhavsar, Ramandeep; Wang, Qingqing; Crawford, Alison; DiLillo, David J.; Vazzana, Kristin; Mohrs, Katja; Dudgeon, Drew; Patel, Supriya; Ahmed, Hassan; Garg, Vidur; Amatulli, Michael; Antao, Olivia Q.; Yan, Yuetian; Wang, Shunhai; Ramos, Willy; Krueger, Pamela; Adler, Christina; Ni, Min; Wei, Yi; Guo, Chunguang; Macdonald, Lynn; Huang, Tammy; Ullman, Erica; Hermann, Aynur; Yancopoulos, George D.; Murphy, Andrew J.; Davis, Samuel; Olson, William C.; Lin, John C.; Smith, Eric; Zhang, Tong
REGN10597: A PD-1-targeted, receptor-masked wild type IL-2 with improved therapeutic window for cancer immunotherapy
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Wu, Jiaxi; Bloch, Nicolin; Chang, Aaron; Bhaysar, Ramandeep; Wang, Qingqing; Patel, Supriya; Garg, Vidur; Shakil, Hassan; Amatulli, Michael; Dudgeon, Drew; Yan, Yuetian; Wang, Shunhai; Ramos, Willy; Krueger, Pamela; Vazzana, Kristin; Crawford, Alison; Idun, Jacqueline; Decker, Corinne; DiLillo, David; Chandwani, Samira; Huang, Tammy; Kirshner, Jessica; Guo, Chungguang; Macdonald, Lynn; Ullman, Erica; Hermann, Aynur; Olson, William; Davis, Samuel; Lin, John; Smith, Eric; Zhang, Tong
VSIG4 interaction with heparan sulfates inhibits VSIG4-complement binding
GLYCOBIOLOGY
IF3.3
2023-06-212
OAAI
Ebstein, Sarah Y.; Rafique, Ashique; Zhou, Yi; Krasco, Amanda; Montalvo-Ortiz, Welby; Yu, Lola; Custodio, Luisaidy; Adam, Rene C.; Bloch, Nicolin; Lee, Ken; Adewale, Funmilola; Vergata, Dominic; Luz, Antonio; Coquery, Sebastien; Daniel, Benjamin; Ullman, Erica; Franklin, Matthew C.; Hermann, Aynur; Huang, Tammy; Olson, William; Davis, Samuel; Murphy, Andrew J.; Sleeman, Matthew A.; Wei, Joyce; Skokos, Dimitris
A PD-1-targeted, receptor-masked IL-2 immunocytokine with maintained potential to engage endogenous IL-2Ra drives selective stimulation of PD-1+ T cells and robust anti-tumor efficacy
CANCER RESEARCH
IF16.6
2023-04-041
PRE
Wu, Jiaxi; Bloch, Nicolin; Chang, Aaron; Bhavsar, Ramandeep; Patel, Supriya; Wang, Qingqing; Ahmed, Hassan Shakil; Garg, Vidur; Amatulli, Michael; Yan, Yuetian; Wang, Shunhai; Dudgeon, Drew; Ramos, Willy; Krueger, Pamela; Rafique, Ashique; Huang, Tammy; Ullman, Erica; Hermann, Aynur; Olson, William; Lin, John; Smith, Eric; Zhang, Tong
Blocking common ? chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-01-117
PRE
Le Floc'h, Audrey; Nagashima, Kirsten; Birchard, Dylan; Scott, George; Ben, Li-Hong; Ajithdoss, Dharani; Gayvert, Kaitlyn; Hernandez, Annabel Romero; Herbin, Olivier; Tay, Amanda; Farrales, Pamela; Korgaonkar, Chandrashekhar K.; Pan, Hao; Shah, Sweta; Kamat, Vishal; Chatterjee, Ishita; Popke, Jon; Oyejide, Adelekan; Lim, Wei Keat; Kim, Jee H.; Huang, Tammy; Franklin, Matthew; Olson, William; Norton, Thomas; Perlee, Lorah; Yancopoulos, George D.; Murphy, Andrew J.; Sleeman, Matthew A.; Orengo, Jamie M.
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

通过CD3亲和力调节产生具有细胞因子释放和生物分布的分化特征的T细胞重定向双特异性抗体

SCIENTIFIC REPORTS
IF3.9
2021-07-1364
OAAI
Haber, Lauric; Olson, Kara; Kelly, Marcus P.; Crawford, Alison; DiLillo, David J.; Tavare, Richard; Ullman, Erica; Mao, Shu; Canova, Lauren; Sineshchekova, Olga; Finney, Jennifer; Pawashe, Arpita; Patel, Supriya; McKay, Ryan; Rizvi, Sahar; Damko, Ermelinda; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; D'Orvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Chen, Ya Ping; Thwaites, Courtney; Dudgeon, Drew; Bray, Kevin; Rafique, Ashique; Huang, Tammy; Delfino, Frank; Hermann, Aynur; Kirshner, Jessica R.; Retter, Marc W.; Babb, Robert; MacDonald, Douglas; Chen, Gang; Olson, William C.; Thurston, Gavin; Davis, Samuel; Lin, John C.; Smith, Eric
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine
SCIENCE IMMUNOLOGY
IF16.3
2020-12-1823
PREAI
Hovhannisyan, Zaruhi; Liu, Nengyin; Khalil-Aguero, Sara; Panea, Casandra; VanValkenburgh, Jeffrey; Zhang, Ruoyu; Lim, Wei Keat; Bai, Yu; Fury, Wen; Huang, Tammy; Garnova, Elena; Fairhurst, Jeanette; Kim, Jee; Aryal, Smita; Ajithdoss, Dharani; Oyejide, Adelekan; Molina-Portela, Maria del Pilar; Hock, E.; Poueymirou, William; Oristian, Nicole Stokes; Brydges, Susannah; Liu, Xia; Olson, William; Yancopoulos, George; Murphy, Andrew J.; Sleeman, Matthew A.; Haxhinasto, Sokol
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

一类增强CD3-bispecific抗体抗肿瘤活性的共刺激CD28-bispecific抗体

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-01-0894
OAAI
Skokos, Dimitris; Waite, Janelle C.; Haber, Lauric; Crawford, Alison; Hermann, Aynur; Ullman, Erica; Slim, Rabih; Godin, Stephen; Ajithdoss, Dharani; Ye, Xuan; Wang, Bei; Wu, Qi; Ramos, Ilyssa; Pawashe, Arpita; Canova, Lauren; Vazzana, Kristin; Ram, Priyanka; Herlihy, Evan; Ahmed, Hassan; Oswald, Erin; Golubov, Jacquelynn; Poon, Patrick; Havel, Lauren; Chiu, Danica; Lazo, Miguel; Provoncha, Kathleen; Yu, Kevin; Kim, Julie; Warsaw, Jacqueline J.; Oristian, Nicole Stokes; Siao, Chia-Jen; Dudgeon, Drew; Huang, Tammy; Potocky, Terra; Martin, Joel; MacDonald, Douglas; Oyejide, Adelekan; Rafique, Ashique; Poueymirou, William; Kirshner, Jessica R.; Smith, Eric; Olson, William; Lin, John; Thurston, Gavin; Sleeman, Matthew A.; Murphy, Andrew J.; Yancopoulos, George D.
Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation

需要用IL-4Rα 抗体dupilumab双重阻断IL-4和IL-13，以广泛抑制2型炎症

ALLERGY
IF12
2020-01-03269
OAAI
Le Floc'h, Audrey; Allinne, Jeanne; Nagashima, Kirsten; Scott, George; Birchard, Dylan; Asrat, Seblewongel; Bai, Yu; Lim, Wei Keat; Martin, Joel; Huang, Tammy; Potocky, Terra B.; Kim, Jee H.; Rafique, Ashique; Papadopoulos, Nicholas J.; Stahl, Neil; Yancopoulos, George D.; Murphy, Andrew J.; Sleeman, Matthew A.; Orengo, Jamie M.
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-12-264
OAAI
Macdonald, Lynn E.; Meagher, Karoline A.; Franklin, Matthew C.; Levenkova, Natasha; Hansen, Johanna; Badithe, Ashok T.; Zhong, Maggie; Krueger, Pamela; Rafique, Ashique; Tu, Naxin; Shevchuk, James; Wadhwa, Saurabh; Ehrlich, George; Bautista, Joannie; Grant, Craig; Esau, Lakeisha; Poueymirou, William T.; Auerbach, Wojtek; Morton, Lori; Babb, Robert; Chen, Gang; Huang, Tammy; MacDonald, Douglas; Graham, Kenneth; Gurer, Cagan; Voronina, Vera A.; McWhirter, John R.; Guo, Chunguang; Yancopoulos, George D.; Murphy, Andrew J.
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2019-06-19100
OAAI
Crawford, Alison; Haber, Lauric; Kelly, Marcus P.; Vazzana, Kristin; Canova, Lauren; Ram, Priyanka; Pawashe, Arpita; Finney, Jennifer; Jalal, Sumreen; Chiu, Danica; Colleton, Curtis A.; Garnova, Elena; Makonnen, Sosina; Hickey, Carlos; Krueger, Pamela; DelFino, Frank; Potocky, Terra; Kuhnert, Jessica; Godin, Stephen; Retter, Marc W.; Duramad, Paurene; MacDonald, Douglas; Olson, William C.; Fairhurst, Jeanette; Huang, Tammy; Martin, Joel; Lin, John C.; Smith, Eric; Thurston, Gavin; Kirshner, Jessica R.
Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

开发治疗非人类灵长类动物晚期埃博拉病毒疾病的临床阶段人类单克隆抗体

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2018-05-31144
OAAI
Pascal, Kristen E.; Dudgeon, Drew; Trefry, John C.; Anantpadma, Manu; Sakurai, Yasuteru; Murin, Charles D.; Turner, Hannah L.; Fairhurst, Jeanette; Torres, Marcela; Rafique, Ashique; Yan, Ying; Badithe, Ashok; Yu, Kevin; Potocky, Terra; Bixler, Sandra L.; Chance, Taylor B.; Pratt, William D.; Rossi, Franco D.; Shamblin, Joshua D.; Wollen, Suzanne E.; Zelko, Justine M.; Carrion, Ricardo, Jr.; Worwa, Gabriella; Staples, Hilary M.; Burakov, Darya; Babb, Robert; Chen, Gang; Martin, Joel; Huang, Tammy T.; Erlandson, Karl; Willis, Melissa S.; Armstrong, Kimberly; Dreier, Thomas M.; Ward, Andrew B.; Davey, Robert A.; Pitt, Margaret L. M.; Lipsich, Leah; Mason, Peter; Olson, William; Stahl, Neil; Kyratsous, Christos A.
Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-05-02125
OAAI
Burova, Elena; Hermann, Aynur; Waite, Janelle; Potocky, Terra; Lai, Venus; Hong, Seongwon; Liu, Matt; Allbritton, Omaira; Woodruff, Amy; Wu, Qi; D'Orvilliers, Amanda; Garnova, Elena; Rafique, Ashique; Poueymirou, William; Martin, Joel; Huang, Tammy; Skokos, Dimitris; Kantrowitz, Joel; Popke, Jon; Mohrs, Markus; MacDonald, Douglas; Ioffe, Ella; Olson, William; Lowy, Israel; Murphy, Andrew; Thurston, Gavin
Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes
ANGIOGENESIS
IF9.2
2016-05-2735
OAAI
MacDonald, Douglas A.; Martin, Joel; Muthusamy, Kathir K.; Luo, Jiann-Kae; Pyles, Erica; Rafique, Ashique; Huang, Tammy; Potocky, Terra; Liu, Yang; Cao, Jingtai; Bono, Francoise; Delesque, Nathalie; Savi, Pierre; Francis, John; Amirkhosravi, Ali; Meyer, Todd; Romano, Carmelo; Glinka, Meredith; Yancopoulos, George D.; Stahl, Neil; Wiegand, Stanley J.; Papadopoulos, Nicholas
Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

在新型人源化mers-cov感染小鼠模型中针对Spike蛋白的完全人抗体的暴露前和暴露后功效

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2015-06-29204
OAAI
Pascal, Kristen E.; Coleman, Christopher M.; Mujica, Alejandro O.; Kamat, Vishal; Badithe, Ashok; Fairhurst, Jeanette; Hunt, Charleen; Strein, John; Berrebi, Alexander; Sisk, Jeanne M.; Matthews, Krystal L.; Babb, Robert; Chen, Gang; Lai, Ka-Man V.; Huang, Tammy T.; Olson, William; Yancopoulos, George D.; Stahl, Neil; Frieman, Matthew B.; Kyratsous, Christos A.

研究方向

暂未获取到该数据
W
William C. Olson
H 指数:58论文数:379被引数:1.4万
G
George D. Yancopoulos
H 指数:203论文数:945被引数:16.4万
A
Ashique Rafique
H 指数:33论文数:184被引数:7,214
A
Andrew Murphy
H 指数:81论文数:457被引数:3.1万
J
Joel Martin
H 指数:20论文数:40被引数:3,049
D
Drew Dudgeon
H 指数:9论文数:56被引数:688
D
Douglas MacDonald
H 指数:25论文数:68被引数:2,688
T
Terra Potocky
H 指数:21论文数:94被引数:2,114
G
Gavin Thurston
H 指数:79论文数:489被引数:3.0万
P
Pamela Krueger
H 指数:9论文数:81被引数:870