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L

Lukáš Tenora

Johns Hopkins University
H指数:14
被引数:1,207

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Next-Generation Neutral Sphingomyelinase-2 Inhibitors with Improved Solubility, Pharmacokinetics, and Efficacy in a Tau Propagation Model

下一代中性鞘磷脂酶-2抑制剂，具有改善的溶解度、药代动力学和tau传播模型中的疗效

Journal of Medicinal Chemistry
IF6.8
2026-01-010
PRE
Arina Ranjit; Lukáš Tenora; Meixiang Huang; Yan Wu; Ajit G. Thomas; Chae Bin Lee; Jesse Alt; R. Zhang; Robert M. Maragakis; Yuxin Zheng; Yu Su; Peter Pietri; Taeyoon Jung; Barbara Stauch Slusher; Rana Rais
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

肿瘤靶向代谢抑制剂前药DRP-104的发现

SCIENCE ADVANCES
IF12.5
2022-11-1652
OAAI
Rais, Rana; Lemberg, Kathryn M.; Tenora, Lukas; Arwood, Matthew L.; Pal, Arindom; Alt, Jesse; Wu, Ying; Lam, Jenny; Aguilar, Joanna Marie H.; Zhao, Liang; Peters, Diane E.; Tallon, Carolyn; Pandey, Rajeev; Thomas, Ajit G.; Dash, Ranjeet P.; Seiwert, Tanguy; Majer, Pavel; Leone, Robert D.; Powell, Jonathan D.; Slusher, Barbara S.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

靶向谷氨酰胺代谢通过调节抑制性髓样细胞增强肿瘤特异性免疫

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2020-06-15280
OA
Oh, Min-Hee; Sun, Im-Hong; Zhao, Liang; Leone, Robert D.; Sun, Im-Meng; Xu, Wei; Collins, Samuel L.; Tam, Ada J.; Blosser, Richard L.; Patel, Chirag H.; Englert, Judson M.; Arwood, Matthew L.; Wen, Jiayu; Chan-Li, Yee; Tenora, Lukas; Majer, Pavel; Rais, Rana; Slusher, Barbara S.; Horton, Maureen R.; Powell, Jonathan D.
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress (vol 44, pg 683, 2019)
NEUROPSYCHOPHARMACOLOGY
IF7.1
2019-03-131
OAAI
Zhu, Xiaolei; Nedelcovych, Michael T.; Thomas, Ajit G.; Hasegawa, Yuto; Moreno-Megui, Aisa; Coomer, Wade; Vohra, Varun; Saito, Atsushi; Perez, Gabriel; Wu, Ying; Alt, Jesse; Prchalova, Eva; Tenora, Lukas; Majer, Pavel; Rais, Rana; Rojas, Camilo; Slusher, Barbara S.; Kamiya, Atsushi

研究方向

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B
Barbara S. Slusher
H 指数:67论文数:588被引数:2.0万
R
Rana Rais
H 指数:38论文数:310被引数:5,927
P
Pavel Majer
H 指数:35论文数:197被引数:4,375
J
Jesse Alt
H 指数:29论文数:207被引数:4,320
Y
Ying Wu
H 指数:27论文数:103被引数:1,921
A
Ajit G. Thomas
H 指数:39论文数:141被引数:6,897
R
Ranjeet Prasad Dash
H 指数:24论文数:86被引数:1,676
M
Michael T. Nedelcovych
H 指数:14论文数:54被引数:813
E
Eva Prchalová
H 指数:13论文数:36被引数:1,581
A
Andrej Jančařík
H 指数:22论文数:65被引数:1,329