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On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents 在树脂上组装新型抗新型隐球菌May1大环抑制剂：通往强效抗真菌药物的一条途径 Krystufek, Robin; Verner, Vaclav; Sacha, Pavel; Hadzima, Martin; Trajhan, Filip; Starkova, Jana; Tloustova, Eva; Dvorakova, Alexandra; Pecina, Adam; Brynda, Jiri; Chalupsky, Karel; Hajek, Miroslav; Boucher, Michael J.; Majer, Pavel; Rezac, Jan; Madhani, Hiten D.; Craik, Charles S.; Konvalinka, Jan 分享 收藏
The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase Cermakova, Katerina; Gregor, Jiri; Kral, Michal; Karlukova, Elena; Navrati, Vaclav; Reiberger, Robert; Albinana, Carlos Berenguer; Bechynsky, Vit; Majer, Pavel; Konvalinka, Jan; Machara, Ales; Kozisek, Milan 分享 收藏
JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging 在PSMA靶向成像期间，JHU-2545优先屏蔽唾液腺和肾脏 Nedelcovych, Michael T.; Dash, Ranjeet P.; Wu, Ying; Choi, Eun Yong; Lapidus, Rena S.; Majer, Pavel; Jancarik, Andrej; Abou, Diane; Penet, Marie-France; Nikolopoulou, Anastasia; Amor-Coarasa, Alex; Babich, John; Thorek, Daniel L.; Rais, Rana; Kratochwil, Clemens; Slusher, Barbara S. 分享 收藏
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery Novotny, Pavel; Humpolickova, Jana; Novakova, Veronika; Stanchev, Stancho; Strisovsky, Kvido; Zgarbova, Michala; Weber, Jan; Krystufek, Robin; Starkova, Jana; Hradilek, Martin; Moravcova, Adela; Gunterova, Jana; Bach, Kathrin; Majer, Pavel; Konvalinka, Jan; Majerova, Tatana 分享 收藏
3'-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex Kral, Michal; Kotacka, Tomas; Reiberger, Robert; Panyrkova, Gabriela; Radilova, Katerina; Osifova, Zuzana; Flieger, Miroslav; Konvalinka, Jan; Majer, Pavel; Kozisek, Milan; Machara, Ales 分享 收藏
Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency Bach, Kathrin; Dohnalek, Jan; Skerlova, Jana; Kuzmik, Jan; Polachova, Edita; Stanchev, Stancho; Majer, Pavel; Fanfrlik, Jindich; Pecina, Adam; Rezac, Jan; Lepsik, Martin; Borshchevskiy, Valentin; Polovinkin, Vitaly; Strisovsky, Kvido 分享 收藏
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery Novotna, Katerina; Tenora, Lukas; Prchalova, Eva; Paule, James; Alt, Jesse; Veeravalli, Vijay; Lam, Jenny; Wu, Ying; Snajdr, Ivan; Gori, Sadakatali; Mettu, Vijaya Saradhi; Tsukamoto, Takashi; Majer, Pavel; Slusher, Barbara S.; Rais, Rana 分享 收藏
Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor Lemberg, Kathryn M.; Ali, Eunus S.; Krecmerova, Marcela; Aguilar, Joanna Marie H.; Alt, Jesse; Peters, Diane E.; Zhao, Liang; Wu, Ying; Nuha, Naziba; Asara, John M.; Staedtke, Verena; Pratilas, Christine A.; Majer, Pavel; Rais, Rana; Ben-Sahra, Issam; Slusher, Barbara S. 分享 收藏
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis Peters, Diane E. E.; Norris, Lauren D. D.; Tenora, Lukas; Snajdr, Ivan; Ponti, Andras K.; Zhu, Xiaolei; Sakamoto, Shinji; Veeravalli, Vijayabhaskar; Pradhan, Manisha; Alt, Jesse; Thomas, Ajit G. G.; Majer, Pavel; Rais, Rana; McDonald, Christine; Slusher, Barbara S. S. 分享 收藏
Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6) Motlova, Lucia; Snajdr, Ivan; Kutil, Zsofia; Andris, Erik; Ptacek, Jakub; Novotna, Adela; Novakova, Zora; Havlinova, Barbora; Tueckmantel, Werner; Draberova, Helena; Majer, Pavel; Schutkowski, Mike; Kozikowski, Alan; Rulisek, Lubomir; Barinka, Cyril 分享 收藏
The combination of immunotherapy and a glutamine metabolism inhibitor represents an effective therapeutic strategy for advanced and metastatic murine pancreatic adenocarcinoma Frejlachova, Andrea; Lencova, Radka; Venhauerova, Anna; Skalickova, Marketa; Uher, Ondrej; Caisova, Veronika; Majer, Pavel; Tenora, Lukas; Hansen, Per; Chmelar, Jindrich; Kopecky, Jan; Zhuang, Zhengping; Pacak, Karel; Zenka, Jan 分享 收藏
Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study Kugler, Michael; Hadzima, Martin; Dzijak, Rastislav; Rampmaier, Robert; Srb, Pavel; Vrzal, Lukas; Voburka, Zdenek; Majer, Pavel; Rezacova, Pavlina; Vrabel, Milan 分享 收藏
Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy Polachova, Edita; Bach, Kathrin; Heuten, Elena; Stanchev, Stancho; Ticha, Anezka; Lampe, Philipp; Majer, Pavel; Langer, Thomas; Lemberg, Marius K.; Strisovsky, Kvido 分享 收藏
Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction 对昆虫发育和繁殖具有物种特异性影响的保幼激素受体的独特肽激动剂 Tumova, Sarka; Milacek, Matej; Snajdr, Ivan; Muthu, Magesh; Tuma, Roman; Reha, David; Jedlicka, Pavel; Bittova, Lenka; Novotna, Adela; Majer, Pavel; Sedlak, David; Jindra, Marek 分享 收藏
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug 肿瘤靶向代谢抑制剂前药DRP-104的发现 Rais, Rana; Lemberg, Kathryn M.; Tenora, Lukas; Arwood, Matthew L.; Pal, Arindom; Alt, Jesse; Wu, Ying; Lam, Jenny; Aguilar, Joanna Marie H.; Zhao, Liang; Peters, Diane E.; Tallon, Carolyn; Pandey, Rajeev; Thomas, Ajit G.; Dash, Ranjeet P.; Seiwert, Tanguy; Majer, Pavel; Leone, Robert D.; Powell, Jonathan D.; Slusher, Barbara S. 分享 收藏
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