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Xu-Nian Wu

sun yatsen university

H指数:8

被引数:270

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Discovery of a Novel Selective and Cell-Active N6-Methyladenosine RNA Demethylase ALKBH5 Inhibitor

发现一种新型的选择性且具有细胞活性的N6-甲基腺苷RNA去甲基化酶ALKBH5抑制剂

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-02-100

PRE

Discovery of Effective Inhibitors Against Phosphodiesterase 9, a Potential Therapeutic Target of Alzheimer's Disease with Antioxidant Capacities

发现具有抗氧化能力的、针对作为阿尔茨海默病潜在治疗靶点的磷酸二酯酶9的有效抑制剂的发现

IF6.6

2025-01-210

OA

Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

ACTA PHARMACEUTICA SINICA B

IF14.6

2022-07-018

OAAI

A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities

ACTA PHARMACEUTICA SINICA B

IF14.6

2022-02-0158

OAAI

Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-12-0813

PREAI

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

ACTA PHARMACEUTICA SINICA B

IF14.6

2018-07-0120

OAAI

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2017-12-2222

OAAI

Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease

ACS CHEMICAL NEUROSCIENCE

IF3.9

2017-08-2339

PREAI