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H

Hilary Wilkinson

Merck & Co. Inc.
H指数:27
被引数:3,481

个人简介

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教育背景

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工作经历

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荣誉奖项

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Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

通过转录抑制和直接CAG重复序列结合抑制亨廷顿病体细胞不稳定性

Nature Communications
IF15.7
2025-11-140
OAAI
Ella W. Mathews; Sydney R. Coffey; Annette Gärtner; Jillian Belgrad; Robert M. Bragg; Daniel O’Reilly; Jeffrey P. Cantle; Cassandra McHugh; Ashley Summers; Joachim Fentz; Tom Schwagarus; Antje Cornelius; Ioannis Lingos; Zoe Burch; Marina Kovalenko; Marissa A. Andrew; C. Frank Bennett; Holly B. Kordasiewicz; Deanna M. Marchionini; Hilary Wilkinson; Thomas F. Vogt; Paolo Beuzer; Ricardo M. Pinto; Anastasia Khvorova; David Howland; Vanessa C. Wheeler; Jeffrey B. Carroll
Orthosteric inhibition of MutSβ ATPase function: First disclosure of MSH3-bound small molecule inhibitors

MutSβ ATP酶功能的正构位点抑制：MSH3结合小分子抑制剂的首次披露

Bioorganic & Medicinal Chemistry Letters
IF2.2
2025-07-030
PRE
Gareth N. Brace; Karsten Tillack; Peter D. Johnson; Markus Ritzefeld; Sabine Schaertl; Elizabeth Frush; Becka Warfield; George Ballantyne; Jung-Hoon Lee; Gabriel Thieulin-Pardo; Stefan Steinbacher; Maren Thomsen; David Witte; Michael Finley; Brinda C. Prasad; Edith Monteagudo; Nikolay V. Plotnikov; Robert E. Pacifici; Michel Maillard; Hilary A. Wilkinson; Tasir S. Haque
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology

开发HDAC4-Selective蛋白降解剂以研究HDAC4在亨廷顿病病理学中的作用

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-09-1319
OAAI
Macabuag, Natsuko; Esmieu, William; Breccia, Perla; Jarvis, Rebecca; Blackaby, Wesley; Lazari, Ovadia; Urbonas, Liudvikas; Eznarriaga, Maria; Williams, Rachel; Strijbosch, Annelieke; Van de Bospoort, Rhea; Matthews, Kim; Clissold, Cole; Ladduwahetty, Tammy; Vater, Huw; Heaphy, Patrick; Stafford, Douglas G.; Wang, Hong -Jun; Mangette, John E.; McAllister, George; Beaumont, Vahri; Vogt, Thomas F.; Wilkinson, Hilary A.; Doherty, Elizabeth M.; Dominguez, Celia
DNA methylation study of Huntington's disease and motor progression in patients and in animal models
NATURE COMMUNICATIONS
IF15.7
2020-09-1047
OAAI
Lu, Ake T.; Narayan, Pritika; Grant, Matthew J.; Langfelder, Peter; Wang, Nan; Kwak, Seung; Wilkinson, Hilary; Chen, Richard Z.; Chen, Jian; Bawden, C. Simon; Rudiger, Skye R.; Ciosi, Marc; Chatzi, Afroditi; Maxwell, Alastair; Hore, Timothy A.; Aaronson, Jeff; Rosinski, Jim; Preiss, Alicia; Vogt, Thomas F.; Coppola, Giovanni; Monckton, Darren; Snell, Russell G.; Yang, X. William; Horvath, Steve
Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
IF3.8
2013-03-2261
OAAI
Chiu, Chi-Sung; Peekhaus, Norbert; Weber, Hans; Adamski, Sharon; Murray, Edward M.; Zhang, Hai Zhuan; Zhao, Jing Zhang; Ernst, Robin; Lineberger, Janet; Huang, Lingyi; Hampton, Richard; Arnold, Beth Anne; Vitelli, Salvatore; Hamuro, Lora; Wang, Wei-Rong; Wei, Nan; Dillon, Greg M.; Miao, Jiangyong; Alves, Stephen E.; Glantschnig, Helmut; Wang, Fubao; Wilkinson, Hilary A.
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
MOLECULAR SYSTEMS BIOLOGY
IF7.7
2012-07-17122
OAAI
Wang, I-Ming; Zhang, Bin; Yang, Xia; Zhu, Jun; Stepaniants, Serguei; Zhang, Chunsheng; Meng, Qingying; Peters, Mette; He, Yudong; Nl, Chester; Slipetz, Deborah; Crackower, Michael A.; Houshyar, Hani; Tan, Christopher M.; Asante-Appiah, Ernest; O'Neill, Gary; Luo, Mingjuan Jane; Thieringer, Rolf; Yuan, Jeffrey; Chiu, Chi-Sung; Lum, Pek Yee; Lamb, John; Bole, Yves; Wilkinson, Hilary A.; Schadt, Eric E.; Dai, Hongyue; Roberts, Christopher
Identification of small molecule estrogen-related receptor α-specific antagonists and homology modeling to predict the molecular determinants as the basis for selectivity over ERRβ and ERRγ

鉴定小分子雌激素相关受体 α 特异性拮抗剂和同源建模以预测分子决定因素作为对err β 和err γ 选择性的基础

DRUG DEVELOPMENT RESEARCH
IF4.2
2008-08-1515
PREAI
Chisamore, Michael J.; Mosley, Ralph T.; Cai, Sheng-Jian; Birzin, Elizabeth T.; O'Donnell, Gregory; Zuck, Paul; Flores, Osvaldo; Schaeffer, James; Rohrer, Susan P.; Chen, J. Don; Wilkinson, Hilary A.
Frespaciguat (MK-5475): A Novel Inhaled Soluble Guanylate Cyclase Stimulator for Pulmonary Hypertension Associated with COPD

Frespaciguat（MK-5475）：一种用于COPD相关肺动脉高压的新型吸入性可溶性鸟苷酸环化酶刺激剂

Journal of Medicinal Chemistry
IF6.8
0
PRE
Alan Whitehead; Raphaëlle Berger; Yong Zhang; Olga Ornoski; Hyunjin Kim; Jason M. Cox; Mary Struthers; Hilary Wilkinson; Beata Zamlynny; Margarita Garcia-Calvo; Kenny Wong; Jodie Kunkel; Aileen House; Peter Mauser; Cherrie Shepherd; Xiaolan Shen; Joseph Metzger; Jenna L. Leschek; Nicole Buist; Jamie M. McCabe Dunn; Alfred Y. Lee; Shiyao Sherrie Xu; Jianmei Pang; Antonio Cabal; Jennifer Wylie; Antonio Pereira; Gino Salituro; Donald Marsh; Timothy Johnson; David Bauman; Subharekha Raghavan

研究方向

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