John W. R. Schwabe - Publications, H-index & Citations

John W. R. Schwabe

University of Leicester

62H指数

183论文数

1.5W被引数

收录论文 78

发表时间

A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome MIDEAS基因中的一个新生错义变异导致MiDAC HDAC复合物的去乙酰化酶活性增加，从而引起一种神经发育综合征。

Nature Communications

IF15.7

2025-11-25

OAAI

Louise Fairall; Kristupas Sirvydis; Robert E. Turnbull; Suzan JG Knottnerus; Oksana Gonchar; Frederick W. Muskett; Rebekah Jukes-Jones; Lonneke van Brussel; Ellen van de Geer; Koen van Gassen; Paul Badenhorst; Diana Johnson; Paulien A. Terhal; Peter M. van Hasselt; Richard H. van Jaarsveld; John WR Schwabe

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation HDAC1表面的突变揭示了特异性复合物组装的分子决定因素及其对基因调控的需求

NUCLEIC ACIDS RESEARCH

IF13.1

2025-09-23

PREAI

Alshehri, Ahmad; Baker, India-May; English, David M.; Fairall, Louise; Collins, Mark O.; Schwabe, John W. R.; Cowley, Shaun M.

Synthetic and structure–activity studies of SP2577 and TCP towards LSD1 targeting PROTACs SP2577和TCP的合成与结构-活性研究及其对LSD1靶向PROTACs的影响

RSC Med. Chem.

IF3.6

2025-08-06

OAAI

Megan E. Coulson ‡; James K. S. Norris ‡; Sean A. Smith; Joshua P. Smalley; John W. R. Schwabe; Shaun M. Cowley; James T. Hodgkinson

Proline Amide Catalyzes Formation of Toxic Crotonaldehyde from Acetaldehyde Under Physiologically Relevant Conditions 脯氨酸酰胺在生理相关条件下催化乙醛生成有毒的巴豆醛

CHEMBIOCHEM

IF2.8

2025-05-21

PREAI

Thomas, Liam A.; Emms, Vicki L.; Vashi, Dipti; Fairall, Louise; Schwabe, John W. R.; Hopkinson, Richard J.

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-11-25

OAAI

Whedon, Samuel D.; Lee, Kwangwoon; Wang, Zhipeng A.; Zahn, Emily; Lu, Congcong; Abeywardana, Maheeshi Yapa; Fairall, Louise; Nam, Eunju; DuBois-Coyne, Sarah; De Ioannes, Pablo; Sheng, Xinlei; Andrei, Adelina; Lundberg, Emily; Jiang, Jennifer; Armache, Karim-Jean; Zhao, Yingming; Schwabe, John W. R.; Wu, Mingxuan; Garcia, Benjamin A.; Cole, Philip A.

Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity Aster-b依赖的雌二醇合成保护雌性小鼠免受饮食诱导的肥胖

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-01-04

OAAI

Xiao, Xu; Kennelly, John P.; Feng, An-Chieh; Cheng, Lijing; Romartinez-Alonso, Beatriz; Bedard, Alexander; Gao, Yajing; Cui, Liujuan; Young, Stephen G.; Schwabe, John W. R.; Tontonoz, Peter

Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator

LIFE SCIENCE ALLIANCE

IF2.9

2023-10-13

OAAI

Tariq, Mishal; Ikeya, Teppei; Togashi, Naoyuki; Fairall, Louise; Kamei, Shun; Mayooramurugan, Sannojah; Abbott, Lauren R.; Hasan, Anab; Bueno-Alejo, Carlos; Sukegawa, Sakura; Romartinez-Alonso, Beatriz; Campillo, Miguel Angel Muro; Hudson, Andrew J.; Ito, Yutaka; Schwabe, John W. R.; Dominguez, Cyril; Tanaka, Kayoko

A potential histone-chaperone activity for the MIER1 histone deacetylase complex

NUCLEIC ACIDS RESEARCH

IF13.1

2023-04-26

OAAI

Wang, Siyu; Fairall, Louise; Pham, Trong Khoa; Ragan, Timothy J.; Vashi, Dipti; Collins, Mark O.; Dominguez, Cyril; Schwabe, John W. R.

Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α 结构引导的方法来缓解对甲状腺激素 α 的抵抗中的转录抑制

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-02-27

OAAI

Romartinez-Alonso, Beatriz; Agostini, Maura; Jones, Heulyn; McLellan, Jayde; Sood, D. Eilidh; Tomkinson, Nicholas; Marelli, Federica; Gentile, Ilaria; Visser, W. Edward; Schoenmakers, Erik; Fairall, Louise; Privalsky, Martin; Moran, Carla; Persani, Luca; Chatterjee, Krishna; Schwabe, John W. R.

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

PLOS PATHOGENS

IF4.9

2022-07-18

OAAI

Bate, Neil; Savva, Christos G.; Moody, Peter C. E.; Brown, Edward A.; Evans, Sian E.; Ball, Jonathan K.; Schwabe, John W. R.; Sale, Julian E.; Brindle, Nicholas P. J.

Optimization of Class I Histone Deacetylase PROTACs Reveals thatHDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-03-16

OAAI

Smalley, Joshua P.; Baker, India M.; Pytel, Wiktoria A.; Lin, Li-Ying; Bowman, Karen J.; Schwabe, John W. R.; Cowley, Shaun M.; Hodgkinson, James T.

Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-02-17

OAAI

Wang, Zhipeng A.; Whedon, Samuel D.; Wu, Mingxuan; Wang, Siyu; Brown, Edward A.; Anmangandla, Ananya; Regan, Liam; Lee, Kwangwoon; Du, Jianfeng; Hong, Jun Young; Fairall, Louise; Kay, Taylor; Lin, Hening; Zhao, Yingming; Schwabe, John W. R.; Cole, Philip A.

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

NATURE COMMUNICATIONS

IF15.7

2021-02-05

OAAI

Fox, Joanna L.; Hughes, Michelle A.; Meng, Xin; Sarnowska, Nikola A.; Powley, Ian R.; Jukes-Jones, Rebekah; Dinsdale, David; Ragan, Timothy J.; Fairall, Louise; Schwabe, John W. R.; Morone, Nobuhiro; Cain, Kelvin; MacFarlane, Marion

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-12-29

OAAI

Xiao, Xu; Kim, Youngjae; Romartinez-Alonso, Beatriz; Sirvydis, Kristupas; Ory, Daniel S.; Schwabe, John W. R.; Jung, Michael E.; Tontonoz, Peter

The topology of chromatin-binding domains in the NuRD deacetylase complex

NUCLEIC ACIDS RESEARCH

IF13.1

2020-12-02

OAAI

Millard, Christopher J.; Fairall, Louise; Ragan, Timothy J.; Savva, Christos G.; Schwabe, John W. R.

Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia

THYROID

IF6.7

2020-11-01

OAAI

Moran, Carla; Seger, Christoph; Taylor, Kevin; Oddy, Susan; Burling, Keith; Rajanayagam, Odelia; Fairall, Louise; McGowan, Anne; Lyons, Greta; Halsall, David; Gurnell, Mark; Schwabe, John; Chatterjee, Krishna; Strey, Christopher

HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions HDAC3脱乙酰化DNA错配修复因子muts β 刺激三联体重复扩增

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-09-08

OAAI

Williams, Gregory M.; Paschalis, Vasileios; Ortega, Janice; Muskett, Frederick W.; Hodgkinson, James T.; Li, Guo-Min; Schwabe, John W. R.; Lahue, Robert S.

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

NATURE COMMUNICATIONS

IF15.7

2020-06-26

OAAI

Turnbull, Robert E.; Fairall, Louise; Saleh, Almutasem; Kelsall, Emma; Morris, Kyle L.; Ragan, T. J.; Savva, Christos G.; Chandru, Aditya; Millard, Christopher J.; Makarova, Olga V.; Smith, Corinne J.; Roseman, Alan M.; Fry, Andrew M.; Cowley, Shaun M.; Schwabe, John W. R.

Diverse nucleosome Site-Selectivity among histone deacetylase complexes

ELIFE

IF0

2020-06-05

OAAI

Wang, Zhipeng A.; Millard, Christopher J.; Lin, Chia-Liang; Gurnett, Jennifer E.; Wu, Mingxuan; Lee, Kwangwoon; Fairall, Louise; Schwabe, John W. R.; Cole, Philip A.

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

CELL REPORTS

IF6.9

2020-02-01

OAAI

Song, Yun; Dagil, Lisbeth; Fairall, Louise; Robertson, Naomi; Wu, Mingxuan; Ragan, T. J.; Savva, Christos G.; Saleh, Almutasem; Morone, Nobuhiro; Kunze, Micha B. A.; Jamieson, Andrew G.; Cole, Philip A.; Hansen, D. Flemming; Schwabe, John W. R.

研究方向