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K

Kevin McGowan

St Jude Children's Research Hospital
H指数:17
被引数:1,761

个人简介

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教育背景

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工作经历

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荣誉奖项

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Direct-to-Biology Enabled Molecular Glue Discovery
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2025-12-010
PRE
Hu, Maowei; Ochoada, Jason; Actis, Marisa; McGowan, Kevin; Jarusiewicz, Jamie A.; Yoshimura, Satoshi; McGrath, Logan; Neelakantan, Uma; Aggarwal, Anup; Mayasundari, Anand; Young, Sarah M.; Zhang, Meng; Yang, Lei; Li, Yong; Mercer, Shea; Babu, M. Madan; Fischer, Marcus; Young, Brandon M.; Yang, Jun J.; Nishiguchi, Gisele; Shelat, Anang A.; Blair, Daniel J.
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound

ONO-2920632 (VU6011887)的发现：一种具有高度选择性且可穿透中枢神经系统的、偏向性激活TREK-2 (TWIK-Related K+ Channel 2)的在体工具化合物

ACS CHEMICAL NEUROSCIENCE
IF0
2025-02-211
OA
Yashiro, K; Iwaki, Y; Urata, H; Kokubo, M; Mori, T; Sekioka, Y; Isami, K; Kato, J; Wieting, J; Mcgowan, KM; Bridges, TM; Boutaud, O; Engers, DW; Denton, JS; Kurata, H; Lindsley, CW
Continuous collective analysis of chemical reactions

化学反应的连续集体分析

NATURE
IF48.5
2024-12-113
PRE
Hu, Maowei; Yang, Lei; Twarog, Nathaniel; Ochoada, Jason; Li, Yong; Vrettos, Eirinaios I.; Torres-Hernandez, Arnaldo X.; Martinez, James B.; Bhatia, Jiya; Young, Brandon M.; Price, Jeanine; McGowan, Kevin; Nguyen, Theresa H.; Shi, Zhe; Anyanwu, Matthew; Rimmer, Mary Ashley; Mercer, Shea; Rankovic, Zoran; Shelat, Anang A.; Blair, Daniel J.
Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α

CK1α 的有效，选择性和口服生物利用度分子胶降解剂的构效关系

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-09-121
PRE
Nishiguchi, Gisele; Caine, Elizabeth A.; Mcgowan, Kevin; Shi, Zhe; Aggarwal, Anup; Mayasundari, Anand; Price, Jeanine; Yang, Lei; Li, Yong; Fu, Xiang; Mascibroda, Lauren G.; Das, Sourav; Daniels, Danette L.; Urh, Marjeta; Klco, Jeffery M.; Riching, Kristin M.; Rankovic, Zoran
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
NATURE COMMUNICATIONS
IF15.7
2024-01-169
OAAI
Nishiguchi, Gisele; Mascibroda, Lauren G.; Young, Sarah M.; Caine, Elizabeth A.; Abdelhamed, Sherif; Kooijman, Jeffrey J.; Miller, Darcie J.; Das, Sourav; McGowan, Kevin; Mayasundari, Anand; Shi, Zhe; Barajas, Juan M.; Hiltenbrand, Ryan; Aggarwal, Anup; Chang, Yunchao; Mishra, Vibhor; Narina, Shilpa; Thomas, Melvin; Loughran, Allister J.; Kalathur, Ravi; Yu, Kaiwen; Zhou, Suiping; Wang, Xusheng; High, Anthony A.; Peng, Junmin; Pruett-Miller, Shondra M.; Daniels, Danette L.; Urh, Marjeta; Shelat, Anang A.; Mullighan, Charles G.; Riching, Kristin M.; Zaman, Guido J. R.; Fischer, Marcus; Klco, Jeffery M.; Rankovic, Zoran
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-05-2763
OAAI
Nishiguchi, Gisele; Keramatnia, Fatemeh; Min, Jaeki; Chang, Yunchao; Jonchere, Barbara; Das, Sourav; Actis, Marisa; Price, Jeanine; Chepyala, Divyabharathi; Young, Brandon; McGowan, Kevin; Slavish, P. Jake; Mayasundari, Anand; Jarusiewicz, Jamie A.; Yang, Lei; Li, Yong; Fu, Xiang; Garrett, Shalandus H.; Papizan, James B.; Kodali, Kiran; Peng, Junmin; Miller, Shondra M. Pruett; Roussel, Martine F.; Mullighan, Charles; Fischer, Marcus; Rankovic, Zoran

研究方向

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G
Gisele Nishiguchi
H 指数:19论文数:68被引数:1,979
Z
Zoran Ranković
H 指数:30论文数:219被引数:6,122
A
Anand Mayasundari
H 指数:19论文数:74被引数:1,548
A
Anup Aggarwal
H 指数:11论文数:25被引数:519
S
Sourav Das
H 指数:16论文数:60被引数:1,124
B
Brandon Young
H 指数:31论文数:137被引数:3,565
Y
Yong Li
H 指数:27论文数:115被引数:4,501
J
Jamie Jarusiewicz
H 指数:11论文数:28被引数:702
M
Marcus Fischer
H 指数:33论文数:161被引数:4,693
C
Craig W. Lindsley
H 指数:86论文数:1,460被引数:3.0万