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C

Chen-Yi Cheung

University of Otago
H指数:17
被引数:897

个人简介

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Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis

基因组规模CRISPRi揭示基因多样性结核分枝杆菌耐药菌株中共享和菌株特异性的脆弱性

Nature Communications
IF15.7
2026-06-010
OA
Wang, XinYue; Jowsey, William J.; Cheung, Chen-Yi; Dickerhof, Nina; Chapman, Cassandra L.; Taka, Jamie R. H.; Hampton, Mark B.; Bashiri, Ghader; Gardner, Paul P.; Fineran, Peter C.; Cook, Gregory M.; Jackson, Simon A.; McNeil, Matthew B.
Advancing the antituberculosis activity of nitropicolinic acids and amides

推进硝基吡嗪甲酸及其酰胺的抗结核活性

European Journal of Medicinal Chemistry
IF5.9
2025-10-290
OAAI
Andrew M. Thompson; Chen-Yi Cheung; Matthew B. McNeil; Ashley C. Campbell; Monika Záhorszká; Jana Korduláková; Giovanni Stelitano; Deborah Recchia; Maria Rosalia Pasca; Baojie Wan; Shahebraj Khan; Dejan S. Nikolic; Gauri S. Shetye; Scott G. Franzblau; William A. Denny; Gregory M. Cook; Kurt L. Krause
Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

维拉帕米及其代谢物去甲维拉帕米通过抑制结核分枝杆菌MmpS5L5外排泵来增强贝达喹啉的活性。

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-04-170
OA
Fountain, Adam J.; Waller, Natalie J. E.; Cheung, Chen - Yi; Jowsey, William; Chrisp, Michael T.; Troll, Mark; Edelstein, Paul H.; Cook, Gregory M.; Ramakrishnan, Lalita
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

全基因组CRISPRi筛选鉴定了耐异烟肼结核分枝杆菌菌株的可药物靶点脆弱性

NATURE COMMUNICATIONS
IF15.7
2024-11-135
OA
Wang, Xinyue; Jowsey, William J.; Cheung, Chen-Yi; Smart, Caitlan J.; Klaus, Hannah R.; Seeto, Noon E. J.; Waller, Natalie J. E.; Chrisp, Michael T.; Peterson, Amanda L.; Ofori-Anyinam, Boatema; Strong, Emily; Nijagal, Brunda; West, Nicholas P.; Yang, Jason H.; Fineran, Peter C.; Cook, Gregory M.; Jackson, Simon A.; McNeil, Matthew B.
Identification of Chemical Scaffolds That Inhibit the Mycobacterium tuberculosis Respiratory Complex Succinate Dehydrogenase

抑制结核分枝杆菌呼吸复合琥珀酸脱氢酶的化学支架的鉴定

ACS INFECTIOUS DISEASES
IF3.8
2024-09-131
PRE
Adolph, Cara; Hards, Kiel; Williams, Zoe C.; Cheung, Chen-Yi; Keighley, Laura M.; Jowsey, William J.; Kyte, Matson; Inaoka, Daniel Ken; Kita, Kiyoshi; Mackenzie, Jared S.; Steyn, Adrie J. C.; Li, Zhengqiu; Yan, Ming; Tian, Guo-Bao; Zhang, Tianyu; Ding, Xiaobo; Furkert, Daniel P.; Brimble, Margaret A.; Hickey, Anthony J. R.; McNeil, Matthew B.; Cook, Gregory M.
A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis
CELL CHEMICAL BIOLOGY
IF7.2
2024-04-017
PRE
Adolph, Cara; Cheung, Chen-Yi; McNeil, Matthew B.; Jowsey, William J.; Williams, Zoe C.; Hards, Kiel; Harold, Liam K.; Aboelela, Ashraf; Bujaroski, Richard S.; Buckley, Benjamin J.; Tyndall, Joel D. A.; Li, Zhengqiu; Langer, Julian D.; Preiss, Laura; Meier, Thomas; Steyn, Adrie J. C.; Rhee, Kyu Y.; Berney, Michael; Kelso, Michael J.; Cook, Gregory M.
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
COMMUNICATIONS BIOLOGY
IF5.1
2022-02-2427
OAAI
Hards, Kiel; Cheung, Chen-Yi; Waller, Natalie; Adolph, Cara; Keighley, Laura; Tee, Zhi Shean; Harold, Liam K.; Menorca, Ayana; Bujaroski, Richard S.; Buckley, Benjamin J.; Tyndall, Joel D. A.; McNeil, Matthew B.; Rhee, Kyu Y.; Opel-Reading, Helen K.; Krause, Kurt; Preiss, Laura; Langer, Julian D.; Meier, Thomas; Hasenoehrl, Erik J.; Berney, Michael; Kelso, Michael J.; Cook, Gregory M.
Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-11-3010
PRE
Tran, Wendy; Kusay, Ali S.; Hawkins, Paige M. E.; Cheung, Chen-Yi; Nagalingam, Gayathri; Pujari, Venugopal; Ford, Daniel J.; Stoye, Alexander; Ochoa, Jessica L.; Audette, Rebecca E.; Hortle, Elinor; Oehlers, Stefan H.; Charman, Susan A.; Linington, Roger G.; Rubin, Eric J.; Dowson, Christopher G.; Roper, David, I; Crick, Dean C.; Balle, Thomas; Cook, Gregory M.; Britton, Warwick J.; Payne, Richard J.

研究方向

暂未获取到该数据
G
Gregory M. Cook
H 指数:64论文数:388被引数:1.3万
K
Kiel Hards
H 指数:27论文数:58被引数:2,861
M
Matthew B. McNeil
H 指数:22论文数:63被引数:1,185
K
Kyu Y. Rhee
H 指数:55论文数:197被引数:9,199
W
Warwick J. Britton
H 指数:72论文数:419被引数:1.8万
M
Michael J. Kelso
H 指数:35论文数:135被引数:4,284
N
Natalie J.E. Waller
H 指数:5论文数:13被引数:152
C
Cara Adolph
H 指数:5论文数:11被引数:133
陆
陆小云
H 指数:39论文数:198被引数:5,197
P
Paige M. E. Hawkins
H 指数:9论文数:17被引数:258