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K

Keefe T. Chan

Peter MacCallum Cancer Centre
H指数:22
被引数:2,649

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Rb-driven transcription limits its tumour-suppressive effects in breast cancer

Rb驱动的转录限制其在乳腺癌中的肿瘤抑制作用

Nature
IF48.5
2026-08-120
OA
April C. Watt; Antonio Ahn; Catherine Blyth; Julia R. Dixon-Douglas; Krutika Ambani; Rhiannon Coulson; Michael Taylor; Keefe T. Chan; Catherine Dietrich; Brendan E. Russ; Susanne Ramm; Christabella A. Mahendra; Kun-Hui Lu; Nichelle Pires; Jesus Garcia-Sannicolas; Olivia Voulgaris; Sheena Nunag; Ching-Seng Ang; Mark A. Dawson; Elgene Lim; Monica Arnedos; Sarat Chandarlapaty; Fabrice André; Shom Goel
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

RNA聚合酶I转录抑制剂CX-5461通过增强同源重组熟练的高级浆液性卵巢癌中的DNA损伤反应来与拓扑异构酶1抑制协同作用

BRITISH JOURNAL OF CANCER
IF6.8
2020-11-1130
OAAI
Yan, Shunfei; Xuan, Jiachen; Brajanovski, Natalie; Tancock, Madeleine R. C.; Madhamshettiwar, Piyush B.; Simpson, Kaylene J.; Ellis, Sarah; Kang, Jian; Cullinane, Carleen; Sheppard, Karen E.; Hannan, Katherine M.; Hannan, Ross D.; Sanij, Elaine; Pearson, Richard B.; Chan, Keefe T.
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

重编程的mRNA翻译驱动对核糖体生物发生的治疗靶向的抗性

EMBO JOURNAL
IF8.3
2020-09-1817
OAAI
Kusnadi, Eric P.; Trigos, Anna S.; Cullinane, Carleen; Goode, David L.; Larsson, Ola; Devlin, Jennifer R.; Chan, Keefe T.; De Souza, David P.; McConville, Malcolm J.; McArthur, Grant A.; Thomas, George; Sanij, Elaine; Poortinga, Gretchen; Hannan, Ross D.; Hannan, Katherine M.; Kang, Jian; Pearson, Richard B.
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

CX-5461激活DNA损伤反应并证明在高级别浆液性卵巢癌中的治疗效果

NATURE COMMUNICATIONS
IF15.7
2020-05-2697
OAAI
Sanij, Elaine; Hannan, Katherine M.; Xuan, Jiachen; Yan, Shunfei; Ahern, Jessica E.; Trigos, Anna S.; Brajanovski, Natalie; Son, Jinbae; Chan, Keefe T.; Kondrashova, Olga; Lieschke, Elizabeth; Wakefield, Matthew J.; Frank, Daniel; Ellis, Sarah; Cullinane, Carleen; Kang, Jian; Poortinga, Gretchen; Nag, Purba; Deans, Andrew J.; Khanna, Kum Kum; Mileshkin, Linda; McArthur, Grant A.; Soong, John; Berns, Els M. J. J.; Hannan, Ross D.; Scott, Clare L.; Sheppard, Karen E.; Pearson, Richard B.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-08-2291
OAAI
AbuHammad, Shatha; Cullinane, Carleen; Martin, Claire; Bacolas, Zoe; Ward, Teresa; Chen, Huiqin; Slater, Alison; Ardley, Kerry; Kirby, Laura; Chan, Keefe T.; Brajanovski, Natalie; Smith, Lorey K.; Rao, Aparna D.; Lelliott, Emily J.; Kleinschmidt, Margarete; Vergara, Ismael A.; Papenfuss, Anthony T.; Lau, Peter; Ghosh, Prerana; Haupt, Sue; Haupt, Ygal; Sanij, Elaine; Poortinga, Gretchen; Pearson, Richard B.; Falk, Hendrik; Curtis, David J.; Stupple, Paul; Devlin, Mark; Street, Ian; Davies, Michael A.; McArthur, Grant A.; Sheppard, Karen E.
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma
CLINICAL CANCER RESEARCH
IF10.2
2015-04-3015
OAAI
Carson, Craig C.; Moschos, Stergios J.; Edmiston, Sharon N.; Darr, David B.; Nikolaishvili-Feinberg, Nana; Groben, Pamela A.; Zhou, Xin; Kuan, Pei Fen; Pandey, Shaily; Chan, Keefe T.; Jordan, Jamie L.; Hao, Honglin; Frank, Jill S.; Hopkinson, Dennis A.; Gibbs, David C.; Alldredge, Virginia D.; Parrish, Eloise; Hanna, Sara C.; Berkowitz, Paula; Rubenstein, David S.; Miller, C. Ryan; Bear, James E.; Ollila, David W.; Sharpless, Norman E.; Conway, Kathleen; Thomas, Nancy E.

研究方向

暂未获取到该数据
R
Richard B. Pearson
H 指数:74论文数:325被引数:1.7万
E
Elaine Sanij
H 指数:31论文数:111被引数:4,803
J
Jian Kang
H 指数:55论文数:286被引数:1.4万
J
James E. Bear
H 指数:48论文数:203被引数:1.1万
R
Ross D. Hannan
H 指数:62论文数:336被引数:1.2万
K
Katherine M. Hannan
H 指数:39论文数:166被引数:5,404
K
Karen E. Sheppard
H 指数:35论文数:192被引数:4,963
A
Anna Trigos
H 指数:11论文数:56被引数:1,050
K
Kaylene J. Simpson
H 指数:40论文数:385被引数:6,943
C
Carleen Cullinane
H 指数:53论文数:369被引数:9,199