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L

Lak Shin Jeong

college of pharmacy

49H指数
481论文数
8.7K被引数
收录论文 146
发表时间
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4’-Thionucleosides as adenosine A3 receptor ligands: a medicinal chemistry perspective4’-硫代核苷作为腺苷A3受体配体：药物化学视角
errMedicinal Chemistry Research
IF3.1
err2026-04-14
err0
PREAI
errHong-Rae Kim; Lak Shin Jeong
err分享
err收藏
Structure-activity relationship analysis of 5′-substituted C2-hexynyl-4′-thioadenosine analogs as dual A2A/A3 adenosine receptor agonists with tunable selectivity and anti-inflammatory activity5′-取代的C2-己炔基-4′-硫代腺苷类似物的构效关系分析，作为具有可调选择性和抗炎活性的双重A2A/A3腺苷受体激动剂
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-11-19
err0
PREAI
errSeung Woo Kim; Jahyun Bok; Hongseok Choi; Gibae Kim; Minjae Kim; Yeonseok Chung; Lak Shin Jeong
err分享
err收藏
Design, Synthesis, and Biological Evaluation of 5′,7-Disubstituted 7-Deaza-adenosine Analogues as Irreversible Pan-FGFR Inhibitors5′,7-二取代7-脱氮腺苷类似物的设计、合成及生物评价：作为不可逆泛FGFR抑制剂
errPharmaceuticals 2025, Vol. 18, Page 1745
IF4.8
err2025-11-18
err0
errOAAI
errJung Hoon Park; Phuong Thao Tran; Hye Lin Ko; Seonghee Mun; Sung Chul Jang; Dong Hyun Moon; Jaeho Han; Jieun Kim; Gibae Kim; Hongseok Choi; Seung Woo Kim; Minjae Kim; Sang Kook Lee; Byung Woo Han; Keon Wook Kang; Lak Shin Jeong
err分享
err收藏
Comparative analysis of LJ-4378 and tirzepatide in mouse models of obesity and weight regainLJ-4378与tirzepatide在肥胖及体重反弹小鼠模型中的比较分析
errArchives of Pharmacal Research
IF7.5
err2025-11-07
err0
errOAAI
errHeeseong Kim; Seung Woo Kim; Cheoljun Choi; SungUg Joo; Gibae Kim; Minjae Kim; Eunsuk Yang; Jangwon Lee; Sukjae Chung; Lak Shin Jeong; Yun-Hee Lee
err分享
err收藏
Design, Synthesis, and Biological Evaluation of C2-(N-Substituted Amino) Truncated 4′-Thioadenosine Derivatives as A2AAR and A3AR Dual LigandsC2-(N-取代氨基) 截短4 ′-硫代腺苷衍生物作为A2AAR和A3AR双配体的设计、合成及生物学评价
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-11-01
err0
PREAI
errJoung, Misuk; Choi, Hongseok; Kim, Minjae; Kim, Seung Woo; Kim, Gibae; Aswar, Vikas R.; Baek, Seungwon; Kim, Hyun-Tae; Huh, Won-Ki; Jeong, Lak Shin
err分享
err收藏
Discovery of a Novel Template, N3-1′-Homologated 4′-Truncated Thiosugar-Substituted Xanthine as an A3AR Antagonist via Conversion of an A1AR Antagonist通过将A1AR拮抗剂转化为A3AR拮抗剂，发现了一种新型模板：N3-1′-同系化的4′-截短的硫糖取代的黄嘌呤。
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-11-01
err0
PREAI
errJoung, Misuk; Kim, Minjae; Choi, Hongseok; Kim, Seung Woo; Kim, Gibae; Aswar, Vikas R.; Baek, Seungwon; Kim, Hyun-Tae; Huh, Won-Ki; Jeong, Lak Shin
err分享
err收藏
Late-Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification核苷骨架中端基炔烃的晚期转化制备腈类化合物：一种多样性构建工具
errAsian Journal of Organic Chemistry
IF2.7
err2025-10-25
err0
errOAAI
errYun A Yum; Vikas R. Aswar; Vidyasagar Gaikwad; Sushil K. Tripathi; Dnyandev B. Jarhad; Prof. Dr. Lak Shin Jeong
err分享
err收藏
Design and development of 5′-modified 7-substituted 4′-Thionucleosides as potent Haspin inhibitors: Synthesis and biological evaluation5′-修饰的7-取代4′-硫代核苷的设计与开发作为强效Haspin抑制剂的合成与生物评价
errBioorganic Chemistry
IF4.7
err2025-10-25
err0
PREAI
errYun A. Yum; Sung Chul Jang; Seung Woo Kim; Dnyandev B. Jarhad; Vikas R. Aswar; Sushil Kumar Tripathi; Eun Seo Bae; Hongseok Choi; Jinha Yu; Sang Kook Lee; Lak Shin Jeong
err分享
err收藏
Design; Synthesis; and Antiviral Activity of 8-Aza Fluoroneplanocin Derivatives Targeting SAH Hydrolase and Viral RdRp设计、合成及靶向SAH水解酶和病毒RdRp的8-氮杂氟诺普兰辛衍生物的抗病毒活性
errACS Medicinal Chemistry Letters
IF4
err2025-10-21
err0
errOAAI
errJiyoon Song; Hongseok Choi; Minjae Kim; Dnyandev B. Jarhad; Yejin Jang; Haemi Lee; Meehyein Kim; Ji Won Park; Tong-Shin Chang; Vikas R. Aswar; Lak Shin Jeong
err分享
err收藏
Regio- and Stereoselective Ribose Modification in Truncated 2; 8-Disubstituted Adenosine Scaffold to Develop Highly Potent A2A Adenosine Receptor Antagonists区域和立体选择性核糖修饰在截短2；8-双取代腺苷骨架中的应用，以开发高活性A2A腺苷受体拮抗剂
errJournal of Medicinal Chemistry
IF6.8
err2025-07-28
err0
PREAI
errGibae Kim; Seung Woo Kim; Hongseok Choi; Ji Yong Kim; Sang Yeop Ahn; Jong Hyun Lee; Jae-Eon Lee; Yong Hyun Jeon; Lak Shin Jeong
err分享
err收藏
Steric influence of 4′-position substituents and C2-Hexynyl group on A3AR antagonism in truncated 4′-Thioadenosine derivatives4′位取代基和C2-己炔基对截短型4′-硫代腺苷衍生物中A3AR拮抗作用的空间影响
errBIOORGANIC CHEMISTRY
IF4.7
err2025-06-01
err0
PREAI
errKim, Minjae; Kim, Jina; Tripathi, Sushil K.; Aswar, Vikas R.; Gaikwad, Vidyasagar; Song, Jiyoon; Kim, Meehyein; Yu, Jinha; Chang, Tong-Shin; Jeong, Lak Shin
err分享
err收藏
Structure-Activity Relationship Analysis of 2-Aryl-8-alkynyl Adenine and Nucleoside Scaffolds as A3 Adenosine Receptor Ligands2-芳基-8-炔基腺嘌呤和核苷支架作为A3腺苷受体配体的构效关系分析
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-04-01
err0
PREAI
errKim, Gibae; Lee, Grim; Jarhad, Dnyandev B.; Gao, Zhan-Guo; Kim, Seung Woo; Joung, Misuk; Jacobson, Kenneth A.; Jeong, Lak Shin
err分享
err收藏
A3AR antagonism mitigates metabolic dysfunction-associated steatotic liver disease by exploiting monocyte-derived Kupffer cell necroptosis and inflammation resolution
errMETABOLISM-CLINICAL AND EXPERIMENTAL
IF11.9
err2025-03-01
err1
PREAI
errPark, Jeong-Su; Ma, Yuan-Qiang; Wang, Feng; Ma, Hwan; Sui, Guoyan; Rustamov, Nodir; Han, Minyeong; Son, Yejin; Park, Chun-Woong; Han, Sang-Bae; Hong, Jin Tae; Jeong, Lak Shin; Lee, Jin; Roh, Yoon Seok
err分享
err收藏
Trifluoromethylation on a Nucleoside Sugar Scaffold: Design and Synthesis of 6′-Trifluoromethylcyclopentenyl-purine and -pyrimidine Nucleosides
errORGANIC LETTERS
IF5
err2025-02-26
err0
PREAI
errSong, Jiyoon; Aswar, Vikas R.; Jarhad, Dnyandev B.; Jeong, Lak Shin
err分享
err收藏
Synthesis and Biological Evaluation of 5′-Deoxy-adenosine Derivatives as A3 Adenosine Receptor Ligands
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-12-11
err2
PREAI
errKim, Minjae; Naik, Siddhi D.; Choi, Hongseok; Kim, Seung Woo; Park, Jung Hoon; Joung, Misuk; Song, Jiyoon; Gaikwad, Vidyasagar B.; Kim, Meehyein; Jeong, Lak Shin
err分享
err收藏
Synthesis and biological evaluation of sugar-modified truncated carbanucleosides as A 2A and A3 adenosine receptor ligands to explore conformational effect to the receptors
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2024-12-01
err2
PREAI
errKim, Minjae; Hyun, Young Eum; Kang, Seung Yeon; Kim, Seung Woo; Park, Jung Hoon; Joung, Misuk; Jeong, Lak Shin
err分享
err收藏
Exploring C2 and N6 Substituent Effects on Truncated 4′-Thioadenosine Derivatives as Dual A2A and A3 Adenosine Receptor Ligands
errCHEMMEDCHEM
IF3.4
err2024-11-21
err1
errOAAI
errNaik, Siddhi D.; Kim, Minjae; Choi, Jiyoung; Kim, Gibae; Woo Kim, Seung; Aswar, Vikas R.; Tripathi, Sushil K.; Gaikwad, Vidyasagar; Yu, Jinha; Jeong, Lak Shin
err分享
err收藏
Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates暴露于三萜-核苷缀合物的肝癌细胞的抗肿瘤活性和转录组测序 (rna-seq) 分析
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-10-01
err0
PREAI
errWang, Qiang; Ma, Fangchao; Wang, Jingchen; Xu, Hongde; Li, Keyan; Cheng, Yung-Yi; Chen, Xiqiang; Qu, Shuhao; Wei, Tingting; Hao, Xiaofei; Kong, Mingyue; Xie, Chengping; Wang, Wei; Wang, Yanli; Jeong, Lak Shin
err分享
err收藏
Structure-Activity Relationship of Truncated 4′-Selenonucleosides: A3 Adenosine Receptor Activity and Binding Selectivity截短的4 ′-硒核苷的构效关系: A3腺苷受体活性和结合选择性
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-08-22
err4
PREAI
errKim, Minjae; Choi, Hongseok; Nayak, Akshata; Tripathi, Sushil K.; Aswar, Vikas R.; Gaikwad, Vidyasagar B.; Jacobson, Kenneth A.; Jeong, Lak Shin
err分享
err收藏
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-06-07
err0
PREAI
errKim, Gibae; Jarhad, Dnyandev B.; Lee, Grim; Kim, Gyudong; Hou, Xiyan; Yu, Jinha; Lee, Chang Soo; Warnick, Eugene; Gao, Zhan-Guo; Ahn, Sang Yeop; Kwak, Dongik; Park, Kichul; Lee, Summer Dabin; Park, Tae-uk; Jung, So-young; Lee, Jong Hyun; Choi, Jong-Ryoul; Kim, Myeongjoong; Kim, Donghyun; Kim, Bongtae; Jacobson, Kenneth A.; Jeong, Lak Shin
err分享
err收藏

研究方向

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合作学者
合作期刊
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Raymond C. Stevens
H 指数: 127 · 论文数: 651
K
Kenneth A. Jacobson
H 指数: 117 · 论文数: 1.3K
R
Robert M. Hoffman
H 指数: 106 · 论文数: 1.6K
G
Godefridus J. Peters
H 指数: 103 · 论文数: 1.4K
K
Kyong Soo Park
H 指数: 100 · 论文数: 928
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