Hugo Geerts - Publications, H-index & Citations

Hugo Geerts

certara predictive technologies, radnor, pennsylvania, usa

39H指数

215论文数

5.8K被引数

收录论文 60

发表时间

IUPHAR review: Computational Psychiatry 2.0. A new tool for supporting combination therapy of psychopharmacology with neuromodulation in schizophrenia IUPHAR综述：计算精神病学2.0。一种支持精神药理学与神经调控联合治疗精神分裂症的新工具

PHARMACOLOGICAL RESEARCH

IF10.5

2025-05-01

OAAI

Geerts, Hugo

Interactions of Therapeutic Antibodies With Presynaptically-Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte-Carlo Simulation Study 神经退行性疾病中治疗性抗体与突触前释放的错误折叠蛋白质的相互作用。一项空间蒙特卡洛模拟研究。

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2025-04-28

OAAI

Jamie Goff; Maryam Khalifa; Shaina M. Short; Piet H. van der Graaf; Hugo Geerts

Quantitative Systems Pharmacology-Based Digital Twins Approach Supplements Clinical Trial Data for Enzyme Replacement Therapies in Pompe Disease

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2024-12-04

PREAI

Kaddi, Chanchala; Tao, Mengdi; Bergeler, Silke; George, Kelly; Geerts, Hugo; van der Graaf, Piet H.; Batista, Julie L.; Foster, Meredith; Ortemann-Renon, Catherine; Zaher, Atef; Haack, Kristina An; Zaph, Susana

Quantitative systems pharmacology-based exploration of relevant anti-amyloid therapy challenges in clinical practice

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS

IF6.8

2024-05-21

OAAI

Geerts, Hugo; Bergeler, Silke; Walker, Mike; Rose, Rachel H.; van der Graaf, Piet H.

Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model

SCIENTIFIC REPORTS

IF3.9

2023-09-01

OAAI

Geerts, Hugo; Bergeler, Silke; Walker, Mike; van der Graaf, Piet H.; Courade, Jean-Philippe

Mechanism-guided analysis of avalglucosidase alfa efficacy on key biomarkers and clinical endpoints in late-onset Pompe disease patients

MOLECULAR GENETICS AND METABOLISM

IF3.5

2023-02-01

PREAI

Kaddi, Chanchala; Tao, Mengdi; Bergeler, Silke; Leiser, Randolph; Walker, Mike; Geerts, Hugo; George, Kelly; Wilson, Catherine; Ortemann-Renon, Catherine; Zaher, Atef; Zaph, Susana

A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2023-01-20

OAAI

Geerts, Hugo; Walker, Mike; Rose, Rachel; Bergeler, Silke; van Der Graaf, Piet H.; Schuck, Edgar; Koyama, Akihiko; Yasuda, Sanae; Hussein, Ziad; Reyderman, Larisa; Swanson, Chad; Cabal, Antonio

Hallmarks of neurodegenerative disease: A systems pharmacology perspective

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2022-08-17

OAAI

Bloomingdale, Peter; Karelina, Tatiana; Ramakrishnan, Vidya; Bakshi, Suruchi; Veronneau-Veilleux, Florence; Moye, Matthew; Sekiguchi, Kazutaka; Meno-Tetang, Guy; Mohan, Aparna; Maithreye, R.; Thomas, Veena A.; Gibbons, Frank; Cabal, Antonio; Bouteiller, Jean-Marie; Geerts, Hugo

Toward Predicting Impact of Common Genetic Variants on Schizophrenia Clinical Responses With Antipsychotics: A Quantitative System Pharmacology Study

FRONTIERS IN NEUROSCIENCE

IF3.2

2021-09-29

OAAI

Spiros, Athan; Geerts, Hugo

Exploring the relation between BOLD fMRI and cognitive performance using a computer-based quantitative systems pharmacology model: Applications to the COMTVAL158MET genotype and ketamine

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2021-09-01

PREAI

Geerts, Hugo; Roberts, Patrick; Spiros, Athan

Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2021-03-29

OAAI

Bloomingdale, Peter; Karelina, Tatiana; Cirit, Murat; Muldoon, Sarah F.; Baker, Justin; McCarty, William J.; Geerts, Hugo; Macha, Sreeraj

A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID-19

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS

IF6.8

2020-11-02

OAAI

Geerts, Hugo; van der Graaf, Piet

Simulating the Effects of Common Comedications and Genotypes on Alzheimer's Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2020-10-27

PREAI

Geerts, Hugo; Spiros, Athan

Salvaging CNS Clinical Trials Halted Due to COVID-19

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2020-06-28

OAAI

Geerts, Hugo; van der Graaf, Piet H.

Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach

ALZHEIMERS & DEMENTIA

IF11.1

2020-04-07

OAAI

Geerts, Hugo; Spiros, Athan

Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2020-03-11

PREAI

Conrado, Daniela J.; Duvvuri, Sridhar; Geerts, Hugo; Burton, Jackson; Biesdorf, Carla; Ahamadi, Malidi; Macha, Sreeraj; Hather, Gregory; Morales, Juan Francisco; Podichetty, Jagdeep; Nicholas, Timothy; Stephenson, Diane; Trame, Mirjam; Romero, Klaus; Corrigan, Brian

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2019-11-24

OAAI

Geerts, Hugo; Wikswo, John; van der Graaf, Piet H.; Bai, Jane P. F.; Gaiteri, Chris; Bennett, David; Swalley, Susanne E.; Schuck, Edgar; Kaddurah-Daouk, Rima; Tsaioun, Katya; Pelleymounter, Mary

Neuronal Circuit-Based Computer Modeling as a Phenotypic Strategy for CNS R&D

FRONTIERS IN NEUROSCIENCE

IF3.2

2019-07-16

OAAI

Geerts, Hugo; Barrett, James E.

Use of quantitative clinical pharmacology to improve early clinical development success in neurodegenerative diseases

EXPERT REVIEW OF CLINICAL PHARMACOLOGY

IF3

2018-08-03

PREAI

Geerts, Hugo; Gieschke, Ronald; Peck, Richard