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L

Lennart Bunch

University of Copenhagen

H指数:25

被引数:2,693

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The N-Acylpolyamine Structure Assigned as Parawixin10 Does Not Display Positive Allosteric Modulatory Activity in EAAT1–3 Radioligand Uptake Assays; nor Does It Enhance Neuronal Survival in Mice in a Dose-Dependent and Statistically Significant Way

被指定为Parawixin10的N-酰基多胺结构在EAAT1–3放射配体摄取测定中不显示正向别构调节活性；并且它也不以剂量依赖性和具有统计学意义的方式增强小鼠神经元存活。

ACS Chemical Neuroscience

IF3.9

2026-04-030

PRE

A Mild Synthetic Protocol for Conversion of Aldehydes to Nitriles Using a Copper Catalyst and LiHMDS as the Nitrogen Source

使用铜催化剂和LiHMDS作为氮源将醛转化为腈的温和合成方法

Organic Letters

IF5

2026-02-260

PRE

Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-08-120

PRE

Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-02-011

OAAI

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-01-032

PRE

Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

FRONTIERS IN CHEMISTRY

IF4.2

2022-11-175

OAAI

(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist

ACS CHEMICAL NEUROSCIENCE

IF3.9

2022-04-273

PRE

Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2022-02-023

PRE

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-12-177

OA

Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring Opening

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2021-06-146

PREAI

From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-11-108

PREAI

β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs)

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-09-012

OAAI

Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT2A/mGlu2 Receptor Complex

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-08-2014

PREAI

A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted L-Proline Analogs as Potential Ligands for the lonotropic Glutamate Receptors

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-02-187

PREAI

Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the lonotropic Glutamate Receptors

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-02-177

OAAI

Identification and Structure-Activity Relationship Study of lmidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

ACS CHEMICAL NEUROSCIENCE

IF3.9

2019-10-019

PREAI

Design and Synthesis of 2,3-trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

ACS CHEMICAL NEUROSCIENCE

IF3.9

2019-05-243

OAAI

Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-07-1617

OAAI

Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors

BIOCHEMICAL PHARMACOLOGY

IF5.6

2018-04-016

PREAI

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-D-aspartate (NMDA) Receptor Antagonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-12-0527

OAAI