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M

Matthijs Moerland

centre for human drug research
H指数:28
被引数:2,615

个人简介

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荣誉奖项

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Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo-Controlled Trial

口服霍乱疫苗接种后免疫反应的表征及霉酚酸吗啉对启动该免疫反应的影响——一项随机、安慰剂对照试验

CLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
2026-08-290
OAAI
Boukje C. Eveleens Maarse; Aliede E. in 't Veld; Hendrika W. Grievink; Manon A.A. Jansen; Matthijs Moerland
IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participants

IL-2 mutein-engrafted抗体MHS552在非临床模型和健康受试者中选择性扩增功能性调节性T细胞

Nature Communications
IF15.7
2026-08-120
OA
Igor Radanović; Michael DiDonato; Anouk C. Meijs; David A. Schubert; Yaiza Diaz-de-Durana; Andrea Kiessling; Thierry Flandre; Hannah Morgan; Claudia Simonett; Justin McMullen; Manon AA. Jansen; Thomas P. Buters; Mahdi Saghari; Pim Gal; Jacobus J. Bosch; Sjoerd H. van der Burg; Susanne Osanto; Morten Bagger; Claudio Calonder; Darbi Witmer; Ulrike Sommer; Frank Waldron-Lynch; Peter Gergely; Nadege Pelletier; Nicole Hartmann; Esther Kamphausen; Magdalena Kistowska; Helene Marsot; Anita Auger-Sarrazin; Celine Rauld; Camille Regairaz; Timothy Tree; Yann Ladner; Naomi B. Klarenbeek; Matthijs Moerland; Robert Rissmann; Glen Spraggon; Leona Gabryšová
Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation

健康志愿者皮内脂多糖的早期免疫反应：泼尼松龙对TLR4介导炎症的影响

Frontiers in Immunology
IF5.9
2026-05-200
OAAI
TP Thomas P. Buters; DT Digna T. de Bruin; PW Pieter W. Hameeteman; WT Wouter ten Voorde; HW Hendrika W. Grievink; MO Michelle Osse; ML Marieke L. de Kam; JD Jeffrey Damman; TP Thierry P. P. van den Bosch; EN Elsa Neubert; RR Robert Rissmann; JB Jacobus Burggraaf; NK Naomi Klarenbeek; MA Manon A. A. Jansen; MM Matthijs Moerland
First-In-Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT-02 Freebase, a CNS-Penetrant NLRP3 Inhibitor

VENT-02游离碱作为中枢神经系统穿透性NLRP3抑制剂的首次人体安全性、药代动力学和药效学研究

Clinical and Translational Science
IF2.8
2026-04-300
OAAI
Lisanne C. A. Smidt; Matthijs Moerland; Manon A. A. Jansen; Philip H. C. Kremer; Alexandra A. J. Sille; Pamela K. Strugala; Erica S. Klaassen; Anick Auger; Silvana Jananji; Rania Faidi; Kelly A. Pike; Loraine Warner; Andre Matta; Xavier Valencia; Ofer Spiegelstein
Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

在健康志愿者中重复皮内脂多糖挑战反应：对临床药理学研究的意义

British Journal of Clinical Pharmacology
IF3
2026-04-220
OAAI
Alexandra A. J. Sillé; Juliette A. van den Noort; Iva Lelios; Diana R. Pereira; Marzia A. Scelsi; Erica S. Klaassen; Philipp Schoenenberger; Naomi B. Klarenbeek; Pierre-Eric Juif; Pascal Espie; Manon A. A. Jansen; Matthijs Moerland; Richard W. D. Welford
Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early-Phase Oncology Drug Development

静脉脂多糖挑战在健康受试者中揭示血液和骨髓的药效学标志物，用于早期肿瘤药物开发

CLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
2026-04-140
OAAI
Igor Radanović; Ingrid Tomljanović; Wieke H. Grievink; Diana R. Pereira; Michelle Osse; Peter van Balen; Maria J. Juachon; Marieke L. de Kam; Lisa Pagan; Manon A.A. Jansen; Matthijs Moerland; Jacobus J. Bosch
POLB 001; a p38 MAPK inhibitor; decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised; double-blind; placebo-controlled study
Frontiers in Immunology
IF5.9
2026-01-230
OAAI
Digna T. de Bruin; Manon A. A. Jansen; Diana R. Pereira; Lisa van Schijndel; Erica S. Klaassen; Marije E. Otto; Jeremy Skillington; Paula Maguire; Liam Tremble; Alan Bell; Laura Maher; Katsuhiro Mihara; Mark Sumeray; Derek W. Gilroy; Naomi B. Klarenbeek; Matthijs Moerland
Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

新生抗原免疫反应在健康志愿者中的研究：来自多次整合钥孔血蓝蛋白挑战研究对重复免疫接种和反应协变量的见解

Frontiers in Pharmacology
IF4.8
2026-01-020
OAAI
Micha N. Ronner†; Marieke L. De Kam; Silke Van Reeuwijk; Jacobus Burggraaf†; Manon A. A. Jansen†; Matthijs Moerland
Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

突破壁垒：作为健康志愿者中血管渗漏可控诱导的体内模型，皮内脂多糖挑战的特征描述

Clinical Pharmacology & Therapeutics
IF5.5
2025-11-150
OAAI
Marella Cornelia Elizabeth van Ruissen; Menno van Diemen; Liza Botros; Ingrid Tomljanovic; Hind Achbo; Dimitra Eleftheriou; Paul Willem Schenk; Naomi Bertine Klarenbeek; Derek William Gilroy; Manon Aleida Adriana Jansen; Matthijs Moerland
Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

早期临床试验中的不良免疫刺激：基于研究者临床经验的关键发现和建议

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
IF3
2025-09-010
OAAI
van den Noort, Juliette A.; van Ruissen, Marella C. E.; Smidt, Lisanne C. A.; Klarenbeek, Naomi B.; Kremer, Philip H. K.; Jansen, Manon A. A.; Burggraaf, Jacobus; van Gerven, Joop M. A.; Moerland, Matthijs
Profiling a Neo-Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study of the KLH Challenge Model

在健康志愿者中分析新抗原驱动的免疫反应：KLH挑战模型的一项随机、双盲、安慰剂对照研究

Clinical Pharmacology & Therapeutics
IF5.5
2025-07-220
OAAI
Micha N. Ronner; Hendrika W. Grievink; Mahdi Saghari; Michelle Osse; Thierry P.P. van den Bosch; Jeffrey Damman; Marieke L. de Kam; Jacobus Burggraaf; Naomi B. Klarenbeek; Manon A. A. Jansen; Matthijs Moerland

研究方向

暂未获取到该数据
J
Jacobus Burggraaf
H 指数:54论文数:359被引数:9,923
M
Manon A. A. Jansen
H 指数:12论文数:46被引数:523
H
Hendrika W. Grievink
H 指数:12论文数:29被引数:621
M
Marieke L. de Kam
H 指数:29论文数:114被引数:2,910
R
Robert Rißmann
H 指数:28论文数:238被引数:2,226
P
Pim Gal
H 指数:16论文数:92被引数:1,113
E
Erica S. Klaassen
H 指数:19论文数:74被引数:973
N
Naomi B. Klarenbeek
H 指数:18论文数:62被引数:1,305
G
Geert Jan Groeneveld
H 指数:37论文数:222被引数:4,990
M
Martijn B. A. van Doorn
H 指数:31论文数:187被引数:3,112