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N

Naomi B. Klarenbeek

Centre for Human Drug Research
H指数:18
被引数:1,306

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荣誉奖项

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Early development of LRX712, preclinical chondroanabolic findings and results from a randomized first-in-human study

LRX712的早期开发、非临床软骨再生发现及来自一项随机首次人体研究的成果

ARTHRITIS RESEARCH & THERAPY
IF4.6
2026-09-180
OAAI
Anouk C. Meijs; Josephina P.M. Vrouwe; Franziska Saxer; Ina Kramer; Angelika Meyer; Jimmy Elliott; Christian Kolter; Serge Summermatter; Gerard Bruin; Azeddine Elhajouji; Frederik E. Stuurman; Jacobus Burggraaf; Andreas Fisch; Bernd Riebesehl; Nicole Gerwin; Sabine Guth-Gundel; Kristen Johnson; Pia Kuss; Stephan Utzinger; David Sanchez-Ramos; Laura Coleman; Celeste Scotti; Karin Meiser; Michaela Kneissel; Ronenn Roubenoff; Naomi B. Klarenbeek; Matthias Schieker
IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participants

IL-2 mutein-engrafted抗体MHS552在非临床模型和健康受试者中选择性扩增功能性调节性T细胞

Nature Communications
IF15.7
2026-08-120
OA
Igor Radanović; Michael DiDonato; Anouk C. Meijs; David A. Schubert; Yaiza Diaz-de-Durana; Andrea Kiessling; Thierry Flandre; Hannah Morgan; Claudia Simonett; Justin McMullen; Manon AA. Jansen; Thomas P. Buters; Mahdi Saghari; Pim Gal; Jacobus J. Bosch; Sjoerd H. van der Burg; Susanne Osanto; Morten Bagger; Claudio Calonder; Darbi Witmer; Ulrike Sommer; Frank Waldron-Lynch; Peter Gergely; Nadege Pelletier; Nicole Hartmann; Esther Kamphausen; Magdalena Kistowska; Helene Marsot; Anita Auger-Sarrazin; Celine Rauld; Camille Regairaz; Timothy Tree; Yann Ladner; Naomi B. Klarenbeek; Matthijs Moerland; Robert Rissmann; Glen Spraggon; Leona Gabryšová
Intravaginal Delivery of Oxybutynin: An Alternative Administration Route to Improve its Pharmacokinetic and Pharmacodynamic Effects

阴道内给予奥昔布宁：改善其药代动力学和药效学效应的替代给药途径

European Urology Open Science
IF4.5
2026-07-230
OAAI
Sophie I. Peltenburg; Anouk C. Meijs; Lisa Pagan; Emily Somohardjo; Henk W. Elzevier; Janneke I.M. van Uhm; Marije E. Otto; Maria J. Juachon; Pamela Strugala; Alexa J. Tibboel; Koos Burggraaf; Bart W.J. Hellebrekers; Naomi B. Klarenbeek
Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

在健康志愿者中重复皮内脂多糖挑战反应：对临床药理学研究的意义

British Journal of Clinical Pharmacology
IF3
2026-04-220
OAAI
Alexandra A. J. Sillé; Juliette A. van den Noort; Iva Lelios; Diana R. Pereira; Marzia A. Scelsi; Erica S. Klaassen; Philipp Schoenenberger; Naomi B. Klarenbeek; Pierre-Eric Juif; Pascal Espie; Manon A. A. Jansen; Matthijs Moerland; Richard W. D. Welford
Clinical Validation of Imaging Biomarkers in Mycosis Fungoides

皮肤T细胞淋巴瘤影像生物标志物的临床验证

Experimental Dermatology
IF3.1
2026-03-110
OAAI
Selinde S. Wind; Elise S. M. Beljaards; Rianne Rijneveld; Lisa Bruijnincx; Tessa Niemeyer-van der Kolk; Manon A. A. Jansen; Yalcin Yavuz; Marieke de Kam; Jacobus Burggraaf; Naomi Klarenbeek; Jacobus Bosch; Koen D. Quint; Maarten H. Vermeer; Robert Rissmann; Next-Generation ImmunoDermatology Consortium (NGID)
POLB 001; a p38 MAPK inhibitor; decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised; double-blind; placebo-controlled study
Frontiers in Immunology
IF5.9
2026-01-230
OAAI
Digna T. de Bruin; Manon A. A. Jansen; Diana R. Pereira; Lisa van Schijndel; Erica S. Klaassen; Marije E. Otto; Jeremy Skillington; Paula Maguire; Liam Tremble; Alan Bell; Laura Maher; Katsuhiro Mihara; Mark Sumeray; Derek W. Gilroy; Naomi B. Klarenbeek; Matthijs Moerland
Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

突破壁垒：作为健康志愿者中血管渗漏可控诱导的体内模型，皮内脂多糖挑战的特征描述

Clinical Pharmacology & Therapeutics
IF5.5
2025-11-150
OAAI
Marella Cornelia Elizabeth van Ruissen; Menno van Diemen; Liza Botros; Ingrid Tomljanovic; Hind Achbo; Dimitra Eleftheriou; Paul Willem Schenk; Naomi Bertine Klarenbeek; Derek William Gilroy; Manon Aleida Adriana Jansen; Matthijs Moerland
Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

早期临床试验中的不良免疫刺激：基于研究者临床经验的关键发现和建议

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
IF3
2025-09-010
OAAI
van den Noort, Juliette A.; van Ruissen, Marella C. E.; Smidt, Lisanne C. A.; Klarenbeek, Naomi B.; Kremer, Philip H. K.; Jansen, Manon A. A.; Burggraaf, Jacobus; van Gerven, Joop M. A.; Moerland, Matthijs
Mild psoriasis as a suitable model for proof-of-mechanism in a phase 1B setting: Results from a double-blind placebo-controlled trial with guselkumab

中重度银屑病作为机制验证的合适模型：一项关于guselkumab的双盲、安慰剂对照试验结果

British Journal of Clinical Pharmacology
IF3
2025-07-280
OAAI
Jannik Rousel; Menthe E. Bergmans; Lisa J. Bruijnincx; Sissi Lin; Tessa Niemeyer-van der Kolk; Roman Bohoslavsky; Yalçin Yavuz; Naomi B. Klarenbeek; Joke A. Bouwstra; Robert Rissmann; Martijn B. A. van Doorn; the Next-Generation ImmunoDermatology Consortium (NGID)
Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo-Controlled, Parallel Group, First-In-Human Study in Healthy Male Participants

新型TRPA1拮抗剂BI 1839100的药理学、安全性与药代动力学证据：一项在健康男性受试者中进行的随机、安慰剂对照、平行组、首次人体研究

cts clinical and translational science
IF0
2025-07-250
OAAI
Marella C. E. van Ruissen; Sebastiaan J. W. van Kraaij; Jana Wolfova; Franziska E. Herrmann; Yanick Botilde; Lutz Wollin; Naomi B. Klarenbeek
Profiling a Neo-Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study of the KLH Challenge Model

在健康志愿者中分析新抗原驱动的免疫反应：KLH挑战模型的一项随机、双盲、安慰剂对照研究

Clinical Pharmacology & Therapeutics
IF5.5
2025-07-220
OAAI
Micha N. Ronner; Hendrika W. Grievink; Mahdi Saghari; Michelle Osse; Thierry P.P. van den Bosch; Jeffrey Damman; Marieke L. de Kam; Jacobus Burggraaf; Naomi B. Klarenbeek; Manon A. A. Jansen; Matthijs Moerland
Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebocontrolled exploratory clinical trial
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
IF11.8
2024-02-011
OAAI
Rousel, Jannik; Bergmans, Menthe E.; van der Meulen, Laura W. J.; Pagan, Lisa; de Bruin, Digna T.; de Kam, Marieke L.; Klarenbeek, Naomi B.; Bouwstra, Joke A.; Seyger, Marieke M. B.; van den Reek, Juul M. P. A.; van der Kolk, Tessa; Rissmann, Robert; van Doorn, Martijn B. A.

研究方向

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T
T. Huizinga
H 指数:140论文数:1,970被引数:10.2万
M
Matthijs Moerland
H 指数:28论文数:148被引数:2,617
C
Cornelia F Allaart
H 指数:56论文数:266被引数:1.2万
P
P. J. S. M. Kerstens
H 指数:33论文数:122被引数:5,268
R
Robert Rißmann
H 指数:28论文数:238被引数:2,227
B
Ben A. C. Dijkmans
H 指数:99论文数:552被引数:3.6万
M
Manon A. A. Jansen
H 指数:12论文数:46被引数:525
J
Jacobus Burggraaf
H 指数:54论文数:359被引数:9,925
M
Martijn B. A. van Doorn
H 指数:31论文数:187被引数:3,115
M
Melek Güler-Yüksel
H 指数:14论文数:29被引数:1,362