Jean‐Sèbastien Hoffmann - Publications, H-index & Citations

Jean‐Sèbastien Hoffmann

universite de toulouse

66H指数

294论文数

1.6W被引数

收录论文 62

发表时间

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors MCM8和MCM9缺乏导致终生的造血DNA损伤增加，进而驱动p53依赖性髓系肿瘤的发生。

Cell Reports

IF6.9

2025-12-18

OAAI

Malik Lutzmann; Florence Bernex; Cindy da Costa de Jesus; Dana Hodroj; Caroline Marty; Isabelle Plo; William Vainchenker; Marie Tosolini; Luc Forichon; Caroline Bret; Sophie Queille; Candice Marchive; Jean-Sébastien Hoffmann; Marcel Méchali

Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs

CANCER RESEARCH

IF16.6

2024-01-31

OAAI

Lumeau, Audrey; Bery, Nicolas; Frances, Audrey; Gayral, Marion; Labrousse, Guillaume; Ribeyre, Cyril; Lopez, Charlene; Nevot, Adele; El Kaoutari, Abdessamad; Hanoun, Naima; Sarot, Emeline; Perrier, Marion; Pont, Frederic; Cerapio, Juan-Pablo; Fournie, Jean-Jacques; Lopez, Frederic; Madrid-Mencia, Miguel; Pancaldi, Vera; Pillaire, Marie-Jeanne; Bergoglio, Valerie; Torrisani, Jerome; Dusetti, Nelson; Hoffmann, Jean-Sebastien; Buscail, Louis; Lutzmann, Malik; Cordelier, Pierre

Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants

LIFE SCIENCE ALLIANCE

IF2.9

2023-10-27

OAAI

Selves, Janick; de Castro e Gloria, Helena; Brunac, Anne-Cecile; Saffi, Jenifer; Guimbaud, Rosine; Brousset, Pierre; Hoffmann, Jean-Sebastien

Human DNA Polymerase η Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

116

OAAI

Rey, Laurie; Sidorova, Julia M.; Puget, Nadine; Boudsocq, Francois; Biard, Denis S. F.; Monnat, Raymond J., Jr.; Cazaux, Christophe; Hoffmann, Jean-Sebastien

The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity

NAR CANCER

IF3.2

2023-03-11

OAAI

Labrousse, Guillaume; Vande Perre, Pierre; Parra, Genis; Jaffrelot, Marion; Leroy, Laura; Chibon, Frederic; Escudie, Frederic; Selves, Janick; Hoffmann, Jean-Sebastien; Guimbaud, Rosine; Lutzmann, Malik

A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-03

OAAI

Dall'Osto, Marina; Pierini, Laura; Valery, Nicolas; Hoffmann, Jean-Sebastien; Pillaire, Marie-Jeanne

The Heritability of Replication Problems

CELLS

IF5.2

2021-06-11

OAAI

Hoffmann, Jean-Sebastien

EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers

CANCER RESEARCH

IF16.6

2020-11-25

OAAI

Prodhomme, Melanie K.; Pommier, Roxane M.; Franchet, Camille; Fauvet, Frederique; Bergoglio, Valerie; Brousset, Pierre; Morel, Anne-Pierre; Brunac, Anne-Cecile; Devouassoux-Shisheboran, Mojgan; Petrilli, Virginie; Moyret-Lalle, Caroline; Hoffmann, Jean-Sebastien; Puisieux, Alain; Tissier, Agnes

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss i n pancreatic cancer

JCI INSIGHT

IF6.1

2019-11-01

OAAI

Muller, David; Shin, Sauyeun; de Rugy, Theo Goullet; Samain, Remi; Baer, Romain; Strehaiano, Manon; Masvidal-Sanz, Laia; Guillermet-Guibert, Julie; Jean, Christine; Tsukumo, Yoshinori; Sonenberg, Nahum; Marion, Frederic; Guilbaud, Nicolas; Hoffmann, Jean-Sebastien; Larsson, Ola; Bousquet, Corinne; Pyronnet, Stephane; Martineau, Yvan

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

CELL REPORTS

IF6.9

2019-09-01

OAAI

Lutzmann, Malik; Bernex, Florence; de Jesus, Cindy da Costa; Hodroj, Dana; Marty, Caroline; Plo, Isabelle; Vainchenker, William; Tosolini, Marie; Forichon, Luc; Bret, Caroline; Queille, Sophie; Marchive, Candice; Hoffmann, Jean-Sebastien; Mechali, Marcel

Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing

EMBO JOURNAL

IF8.3

2019-07-11

OAAI

Gonzalez Besteiro, Marina A.; Calzetta, Nicolas L.; Loureiro, Sofia M.; Habif, Martin; Betous, Remy; Pillaire, Marie-Jeanne; Maffia, Antonio; Sabbioneda, Simone; Hoffmann, Jean-Sebastien; Gottifredi, Vanesa

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

NATURE COMMUNICATIONS

IF15.7

2019-02-22

104

OAAI

Bianco, Julien N.; Bergoglio, Valerie; Lin, Yea-Lih; Pillaire, Marie-Jeanne; Schmitz, Anne-Lyne; Gilhodes, Julia; Lusque, Amelie; Mazieres, Julien; Lacroix-Triki, Magali; Roumeliotis, Theodoros, I; Choudhary, Jyoti; Moreaux, Jerome; Hoffmann, Jean-Sebastien; Tourriere, Helene; Pasero, Philippe

DNA replication stress triggers Rapid DNA Replication Fork Breakage by Artemis and XPF

PLOS GENETICS

IF3.7

2018-07-30

OAAI

Betous, Remy; de Rugy, Theo Goullet; Pelegrini, Alessandra Luiza; Queille, Sophie; de Villartay, Jean-Pierre; Hoffmann, Jean-Sebastien

DNA polymerase v gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status

HAEMATOLOGICA

IF7.9

2018-03-22

OAAI

Grgurevic, Srdana; Montilla-Perez, Patricia; Bradbury, Alice; Gilhodes, Julia; Queille, Sophie; Pelofy, Sandrine; Bancaud, Aurelien; Filleron, Thomas; Ysebaert, Loic; Recher, Christian; Laurent, Guy; Fournie, Jean-Jacques; Cazaux, Christophe; Quillet-Mary, Anne; Hoffmann, Jean-Sebastien

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells (vol 8, 15983, 2017)

NATURE COMMUNICATIONS

IF15.7

2017-10-26

OAAI

Lai, Xianning; Broderick, Ronan; Bergoglio, Valerie; Zimmer, Jutta; Badie, Sophie; Niedzwiedz, Wojciech; Hoffmann, Jean-Sebastien; Tarsounas, Madalena

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

NATURE COMMUNICATIONS

IF15.7

2017-07-17

OAAI

Lai, Xianning; Broderick, Ronan; Bergoglio, Valerie; Zimmer, Jutta; Badie, Sophie; Niedzwiedz, Wojciech; Hoffmann, Jean-Sebastien; Tarsounas, Madalena

Proper sister chromatid disjunction requires CDA and PARP-1

CELL CYCLE

IF3.4

2017-06-26

OAAI

Hoffmann, Jean-Sebastien; Cordelier, Pierre

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

CELL REPORTS

IF6.9

2016-11-01

119

OAAI

Garcia-Exposito, Laura; Bournique, Elodie; Bergoglio, Valerie; Bose, Arindam; Barroso-Gonzalez, Jonathan; Zhang, Sufang; Roncaioli, Justin L.; Lee, Marietta; Wallace, Callen T.; Watkins, Simon C.; Opresko, Patricia L.; Hoffmann, Jean-Sebastien; O'Sullivan, Roderick J.

Cyclin Kinase-independent role of p21cDKN1A in the promotion of nascent DNA elongation in unstressed cells

ELIFE

IF0

2016-10-14

OAAI

Mansilla, Sabrina F.; Bertolin, Agustina P.; Bergoglio, Valerie; Pillaire, Marie-Jeanne; Besteiro, Marina A. Gonzalez; Luzzani, Carlos; Miriuka, Santiago G.; Cazaux, Christophe; Hoffmann, Jean-Sebastien; Gottifredi, Vanesa

Analysis of DNA Replication by Optical Mapping in Nanochannels 通过纳米通道中的光学映射分析DNA复制

SMALL

IF12.1

2016-09-14

OAAI

Lacroix, Joris; Pelofy, Sandrine; Blatche, Charline; Pillaire, Marie-Jeanne; Huet, Sebastien; Chapuis, Catherine; Hoffmann, Jean-Sebastien; Bancaud, Aurelien

研究方向