未登录 Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial 二甲双胍和身体表现：英格兰可能发生肌肉减少症和身体前虚弱或虚弱老年人的研究（MET-PREVENT）：一项双盲、随机、安慰剂对照试验 Witham, Miles D.; McDonald, Claire; Wilson, Nina; Rennie, Katherine J.; Bardgett, Michelle; Bradley, Penny; Clegg, Andrew P.; Connolly, Stephen; Hancock, Helen; Hiu, Shaun; Nicholson, Karen; Robertson, Laura; Simms, Laura; Steel, Alison J.; Steves, Claire J.; Storey, Bryony; Wason, James; von Zglinicki, Thomas; Sayer, Avan A. 分享 收藏
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A CLINICALLY RELEVANT IN VIVO MODEL RECAPITULATES THE LATE EFFECTS OF RADIOTHERAPY IN CHILDHOOD MEDULLOBLASTOMA SURVIVORS Egnuni, T.; Castle, J.; Shaw, G.; Weller, D.; Fielder, E.; Singh, M.; Skinner, R.; von Zglinicki, T.; Clifford, S.; Miwa, S.; Hicks, D.; Short, S. C. 分享 收藏
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Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence 衰老中的血脑屏障功能障碍是由脑内皮衰老介导的 Novo, Joao P.; Gee, Lucy; Caetano, Carolina A.; Tome, Ines; Vilaca, Andreia; von Zglinicki, Thomas; Moreira, Irina S.; Jurk, Diana; Rosa, Susana; Ferreira, Lino 分享 收藏
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule Kelly, George; Kataura, Tetsushi; Panek, Johan; Ma, Gailing; Salmonowicz, Hanna; Davis, Ashley; Kendall, Hannah; Brookes, Charlotte; Ayine-Tora, Daniel Moscoh; Banks, Peter; Nelson, Glyn; Dobby, Laura; Pitrez, Patricia R.; Booth, Laura; Costello, Lydia; Richardson, Gavin D.; Lovat, Penny; Przyborski, Stefan; Ferreira, Lino; Greaves, Laura; Szczepanowska, Karolina; von Zglinicki, Thomas; Miwa, Satomi; Brown, Max; Flagler, Michael; Oblong, John E.; Bascom, Charles C.; Carroll, Bernadette; Reynisson, Johannes; Korolchuk, Viktor I. 分享 收藏
IN VIVO MODELLING RECAPITULATES RADIOTHERAPY DELIVERY AND LATE-EFFECT PROFILE FOR CHILDHOOD MEDULLOBLASTOMA Castle, Jemma; Shaw, Gary; Weller, Dominic; Fielder, Edward; Egnuni, Teklu; Singh, Mankaran; Skinner, Roderick; von Zglinicki, Thomas; Clifford, Steven C.; Short, Susan; Miwa, Satomi; Hicks, Debbie 分享 收藏
In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma Castle, Jemma; Shaw, Gary; Weller, Dominic; Fielder, Edward; Egnuni, Teklu; Singh, Mankaran; Skinner, Roderick; von Zglinicki, Thomas; Clifford, Steven C.; Short, Susan C.; Miwa, Satomi; Hicks, Debbie 分享 收藏
Efficacy and safety of metformin as a therapy for older people with sarcopenia and frailty - the MET-PREVENT randomised trial Witham, M. D.; McDonald, C.; Clegg, A. P.; Hancock, H.; Hiu, S.; Nicholson, K.; Storey, B.; Simms, L.; Steves, C. J.; von Zglinicki, T.; Wason, J.; Wilson, N.; Sayer, A. A. 分享 收藏
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence Riviere-Cazaux, Cecile; Carlstrom, Lucas P.; Neth, Bryan J.; Olson, Ian E.; Rajani, Karishma; Rahman, Masum; Ikram, Samar; Mansour, Moustafa A.; Mukherjee, Bipasha; Warrington, Arthur E.; Short, Susan C.; von Zglinicki, Thomas; Brown, Desmond A.; Burma, Sandeep; Tchkonia, Tamar; Schafer, Marissa J.; Baker, Darren J.; Kizilbash, Sani H.; Kirkland, James L.; Burns, Terry C. 分享 收藏
Aging and chronic inflammation: highlights from a multidisciplinary workshop Saavedra, Danay; Ane-Kouri, Ana Laura; Barzilai, Nir; Caruso, Calogero; Cho, Kyung-Hyun; Fontana, Luigi; Franceschi, Claudio; Frasca, Daniela; Ledon, Nuris; Niedernhofer, Laura J.; Pereira, Karla; Robbins, Paul D.; Silva, Alexa; Suarez, Gisela M.; Berghe, Wim Vanden; von Zglinicki, Thomas; Pawelec, Graham; Lage, Agustin 分享 收藏
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Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice Fielder, Edward; Wan, Tengfei; Alimohammadiha, Ghazaleh; Ishaq, Abbas; Low, Evon; Weigand, B. Melanie; Kelly, George; Parker, Craig; Griffin, Brigid; Jurk, Diana; Korolchuk, Viktor, I; von Zglinicki, Thomas; Miwa, Satomi; Isales, Carlos 分享 收藏
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Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner 中性粒细胞以ROS依赖的方式诱导旁分泌端粒功能障碍和衰老 Lagnado, Anthony; Leslie, Jack; Ruchaud-Sparagano, Marie-Helene; Victorelli, Stella; Hirsova, Petra; Ogrodnik, Mikolaj; Collins, Amy L.; Vizioli, Maria Grazia; Habiballa, Leena; Saretzki, Gabriele; Evans, Shane A.; Salmonowicz, Hanna; Hruby, Adam; Geh, Daniel; Pavelko, Kevin D.; Dolan, David; Reeves, Helen L.; Grellscheid, Sushma; Wilson, Colin H.; Pandanaboyana, Sanjay; Doolittle, Madison; von Zglinicki, Thomas; Oakley, Fiona; Gallage, Suchira; Wilson, Caroline L.; Birch, Jodie; Carroll, Bernadette; Chapman, James; Heikenwalder, Mathias; Neretti, Nicola; Khosla, Sundeep; Masuda, Claudio Akio; Tchkonia, Tamar; Kirkland, James L.; Jurk, Diana; Mann, Derek A.; Passos, Joao F. 分享 收藏
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