New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe EpilepsyACS CHEMICAL NEUROSCIENCEIF3.92024-01-042PRE
Clinical pharmacological innovation in the treatment of depression抑郁症治疗的临床药理学创新EXPERT REVIEW OF CLINICAL PHARMACOLOGYIF32023-04-0614PRE
Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without SedationJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICSIF3.82023-04-017OAAI
Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analogGABAkine KRM-II-81和氘代类似物的抗惊厥活性比较DRUG DEVELOPMENT RESEARCHIF4.22023-02-072OA
GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptorsPHARMACOLOGY & THERAPEUTICSIF12.52022-06-0166OAAI
The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance developmentPHARMACOLOGY BIOCHEMISTRY AND BEHAVIORIF2.52020-09-0118OAAI
Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure EffectsACS CHEMICAL NEUROSCIENCEIF3.92020-07-3019OAAI
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d] pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrierBIOORGANIC & MEDICINAL CHEMISTRYIF32020-06-0112OAAI
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain InjuryJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICSIF3.82020-01-0130OAAI
Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoniPLOS NEGLECTED TROPICAL DISEASESIF3.42019-11-157OAAI
The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in ratsPHARMACOLOGY BIOCHEMISTRY AND BEHAVIORIF2.52019-05-0133OAAI
An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptorsPHARMACOLOGY BIOCHEMISTRY AND BEHAVIORIF2.52018-07-0117PREAI
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosynthesisJOURNAL OF MEDICINAL CHEMISTRYIF6.82016-08-2642OAAI
Structure Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter (vol 57, pg 8152, 2014)JOURNAL OF MEDICINAL CHEMISTRYIF6.82016-04-150OAAI
Synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as targeted antifolatesCANCER RESEARCHIF16.62015-08-010PRE
Synthesis and preclinical evaluation of novel 6-substituted pyrrolo[2,3-d] pyrimidines as targeted antifolatesCANCER RESEARCHIF16.62014-10-010PRE
Structure-Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate TransporterJOURNAL OF MEDICINAL CHEMISTRYIF6.82014-09-1932OAAI