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H

Herman D. Lim

monash university

H指数:25

被引数:2,132

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Leveraging Fragment-Based Drug Discovery to Advance 3D Scaffolds into Potent Ligands: Application to the Histamine H1 Receptor

IF0

2026-01-310

OA

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor

鉴定多巴胺D2受体正位别构调节剂的脂质暴露外旋结合位点

ACS CHEMICAL NEUROSCIENCE

IF3.9

2025-05-150

PRE

Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-02-258

OAAI

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

SCIENCE SIGNALING

IF6.6

2020-03-31227

OA

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

IF0

2020-01-2724

OA

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

ACS CHEMICAL BIOLOGY

IF3.8

2019-07-2417

OAAI

A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-04-2325

OAAI

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

SCIENCE SIGNALING

IF6.6

2017-05-2336

OAAI

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

ACS CHEMICAL NEUROSCIENCE

IF3.9

2016-03-0321

OAAI

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-12-3140

OA

Proof of Concept Study for Designed Multiple Ligands Targeting the Dopamine D2, Serotonin 5-HT2A, and Muscarinic M1 Acetylcholine Receptors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-01-3015

PREAI

Identification of a Novel Allosteric Binding Site in the CXCR2 Chemokine Receptor

MOLECULAR PHARMACOLOGY

IF3

2011-12-0131

PREAI

Molecular Determinants of Ligand Binding Modes in the Histamine H4 Receptor: Linking Ligand-Based Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Models to in Silico Guided Receptor Mutagenesis Studies

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-11-0752

PRE

Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?

EXPERT OPINION ON INVESTIGATIONAL DRUGS

IF4.1

2011-10-1357

PREAI

N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2011-10-0126

OAAI

Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4 Receptor Affinity and Subtly Govern H4/H3 Subtype Selectivity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-02-2441

PREAI

The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-α-PGP) does not interact directly with human CXCR1 and CXCR2

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2010-09-0115

PREAI

Molecular Determinants of Ligand Binding to H4R Species Variants

MOLECULAR PHARMACOLOGY

IF3

2010-05-0159

PREAI

Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: Synthesis, pharmacological evaluation, and cross-target QSAR studies

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2009-06-0134

PRE

Nonpeptidergic Allosteric Antagonists Differentially Bind to the CXCR2 Chemokine Receptor

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2009-05-0148

PREAI