David R. Janero - Publications, H-index & Citations

Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure 大麻素1受体变构调节剂的设计，合成和药理学分析: C2-group GAT211同类物降低眼内压的临床前功效

IF4.9

2023-11-07

PREAI

Janero, David R.

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-11-01

PREAI

Garai, Sumanta; Schaffer, Peter C.; Laprairie, Robert B.; Janero, David R.; Pertwee, Roger G.; Straiker, Alex; Thakur, Ganesh A.

Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy

Tackling the reproducibility problem to empower translation of preclinical academic drug discovery: is there an answer?

IF6.8

2021-04-07

PREAI

Garai, Sumanta; Leo, Luciana M.; Szczesniak, Anna-Maria; Hurst, Dow P.; Schaffer, Peter C.; Zagzoog, Ayat; Black, Tallan; Deschamps, Jeffrey R.; Miess, Elke; Schulz, Stefan; Janero, David R.; Straiker, Alex; Pertwee, Roger G.; Abood, Mary E.; Kelly, Melanie E. M.; Reggio, Patricia H.; Laprairie, Robert B.; Thakur, Ganesh A.

Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility 大麻素1型受体激动剂阳性变构调节剂的2-苯基吲哚支架周围的集中结构-活性关系分析: 活性和溶解度增强的位点III芳环同源物

IF4.9

2021-03-04

OAAI

Janero, David R.

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-11-01

PREAI

Schaffer, Peter C.; Kulkarni, Pushkar M.; Janero, David R.; Thakur, Ganesh A.

Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

Aliphatic Azides as Selective Cysteine Labeling Reagents for Integral Membrane Proteins

IF6.8

2019-11-22

OAAI

Garai, Sumanta; Kulkarni, Pushkar M.; Schaffer, Peter C.; Leo, Luciana M.; Brandt, Asher L.; Zagzoog, Ayat; Black, Tallan; Lin, Xiaoyan; Hurst, Dow P.; Janero, David R.; Abood, Mary E.; Zimmowitch, Anaelle; Straiker, Alex; Pertwee, Roger G.; Kelly, Melanie; Szczesniak, Anna-Maria; Denovan-Wright, Eileen M.; Mackie, Ken; Hohmann, Andrea G.; Reggio, Patricia H.; Laprairie, Robert B.; Thakur, Ganesh A.

Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets

IF6.8

2018-11-16

PREAI

Szymanski, Dennis; Papanastasiou, Malvina; Pandarinathan, Lakshmipathi; Zvonok, Nikolai; Janero, David R.; Pavlopoulos, Spiro; Vouros, Paul; Makriyannis, Alexandros

BIOCHEMICAL PHARMACOLOGY

IF5.6

2017-03-01

OAAI

Mallipeddi, Srikrishnan; Janero, David R.; Zvonok, Nikolai; Makriyannis, Alexandros

Human Cannabinoid Receptor 2 Ligand-Interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose 人类大麻素受体2配体相互作用基序: 跨膜螺旋2半胱氨酸，C2.59(89)，作为经典大麻素激动剂活性和结合姿势的决定因素

Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

IF3.9

2017-03-01

PREAI

Zhou, Han; Peng, Yan; Halikhedkar, Aneetha; Fan, Pusheng; Janero, David R.; Thakur, Ganesh A.; Mercier, Richard W.; Sun, Xin; Ma, Xiaoyu; Makriyannis, Alexandros

Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target

IF3.9

2017-02-07

PREAI

Laprairie, Robert B.; Kulkarni, Pushkar M.; Deschamps, Jeffrey R.; Kelly, Melanie E. M.; Janero, David R.; Cascio, Maria G.; Stevenson, Lesley A.; Pertwee, Roger G.; Kenakin, Terrence P.; Denovan-Wright, Eileen M.; Thakur, Ganesh A.

The reproducibility issue and preclinical academic drug discovery: educational and institutional initiatives fostering translation success

IF4.9

2016-10-21

OAAI

Janero, David R.; Thakur, Ganesh A.

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

IF4.9

2016-07-25

PREAI

Janero, David R.

Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency A ROLE FOR GLOBAL CONFORMATIONAL CHANGES

IF3.9

2016-04-25

OAAI

Laprairie, Robert B.; Kulkarni, Abhijit R.; Kulkarni, Pushkar M.; Hurst, Dow P.; Lynch, Diane; Reggio, Patricia H.; Janero, David R.; Pertwee, Roger G.; Stevenson, Lesley A.; Kelly, Melanie E. M.; Denovan-Wright, Eileen M.; Thakur, Ganesh A.

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-02-01

OAAI

Tyukhtenko, Sergiy; Karageorgos, Ioannis; Rajarshi, Girija; Zvonok, Nikolai; Pavlopoulos, Spiro; Janero, David R.; Makriyannis, Alexandros

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

Molecular-Interaction and Signaling Profiles of AM3677, a Novel Covalent Agonist Selective for the Cannabinoid 1 Receptor

IF6.8

2015-11-28

OAAI

Kulkarni, Pushkar M.; Kulkarni, Abhijit R.; Korde, Anisha; Tichkule, Ritesh B.; Laprairie, Robert B.; Denovan-Wright, Eileen M.; Zhou, Han; Janero, David R.; Zvonok, Nikolai; Makriyannis, Alexandros; Cascio, Maria G.; Pertwee, Roger G.; Thakur, Ganesh A.

Perspectives on substance abuse drug discovery

IF3.9

2015-05-29

OAAI

Janero, David R.; Yaddanapudi, Suma; Zvonok, Nikolai; Subramanian, Kumar V.; Shukla, Vidyanand G.; Stahl, Edward; Zhou, Lei; Hurst, Dow; Wager-Miler, James; Bohn, Laura M.; Reggio, Patricia H.; Mackie, Ken; Makriyannis, Alexandros