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J

Joerg J. Moehrle

medicines for malaria venture, geneva 1215, switzerland.
H指数:16
被引数:1,048

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荣誉奖项

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Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum

联合使用芦可替尼可减轻炎症并增强免疫力，在实验性感染恶性疟原虫的志愿者中。

Science Translational Medicine
IF14.6
2025-11-260
OAAI
Rebecca Webster; Damian A. Oyong; Stacey Llewellyn; Azrin N. Abd-Rahman; Adam J. Potter; Reena Mukhiya; Nischal Sahai; Indika Leelasena; Eniko Ujvary; Sue Mathison; Dean W. Andrew; Luzia Bukali; Fabian de Labastida Rivera; Jessica Engel; Megan S. F. Soon; Teija Frame; Julianne Hamelink; Mayimuna Nalubega; Nicholas L. Dooley; Jessica R. Loughland; Tran Nguyen; Yael Rosenberg-Hasson; Sofia Maysel-Auslender; Natalia Sigal; Kira Foygel; Jeremy Gower; Jenny Peters; Ria Woo; Fiona Amante; Timothy N. C. Wells; Stephan Chalon; Joerg J. Moehrle; James S. McCarthy; Geoffrey W. Birrell; Michael D. Edstein; Michael Leipold; Gerlinde Obermoser; Holden Maecker; Christian R. Engwerda; Bridget E. Barber; Michelle J. Boyle
Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2023-06-158
OAAI
Demarta-Gatsi, Claudia; Andenmatten, Nicole; Jimenez-Diaz, Maria-Belen; Gobeau, Nathalie; Cherkaoui-Rabti, Mohammed H.; Fuchs, Aline; Diaz, Pablo; Berja, Sandra; Sanchez, Rebeca; Gomez, Hazel; Ruiz, Estibaliz; Sainz, Paula; Salazar, Eider; Gil-Merino, Rodrigo; Mendoza, Luis Manuel; Eguizabal, Cristina; Leroy, Didier; Moehrle, Joerg J.; Tornesi, Belen; Angulo-Barturen, Inigo
Characterizing the Blood-Stage Antimalarial Activity of Tafenoquine in Healthy Volunteers Experimentally Infected With Plasmodium falciparum

在实验感染恶性疟原虫的健康志愿者中表征Tafenoquine的血液阶段抗疟活性

CLINICAL INFECTIOUS DISEASES
IF7.3
2023-02-1611
OAAI
Barber, Bridget E.; Abd-Rahman, Azrin N.; Webster, Rebecca; Potter, Adam J.; Llewellyn, Stacey; Marquart, Louise; Sahai, Nischal; Leelasena, Indika; Birrell, Geoffrey W.; Edstein, Michael D.; Shanks, G. Dennis; Wesche, David; Moehrle, Joerg J.; McCarthy, James S.
Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study
LANCET INFECTIOUS DISEASES
IF31
2022-06-0119
OAAI
Barber, Bridget E.; Fernandez, Melissa; Patel, Hardik Babubhai; Barcelo, Catalina; Woolley, Stephen D.; Patel, Harilal; Llewellyn, Stacey; Abd-Rahman, Azrin N.; Sharma, Sunil; Jain, Mukul; Ghoghari, Ashok; Di Resta, Ilaria; Fuchs, Aline; Deni, Ioanna; Yeo, Tomas; Mok, Sachel; Fidock, David A.; Chalon, Stephan; Moehrle, Joerg J.; Parmar, Deven; McCarthy, James S.; Kansagra, Kevinkumar
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2022-01-187
OAAI
Chughlay, M. Farouk; Barnes, Karen, I; El Gaaloul, Myriam; Abla, Nada; Mohrle, Jorg J.; Griffin, Paul; van Giersbergen, Paul; Reuter, Stephanie E.; Schultz, Hayley B.; Kress, Anita; Tapley, Peter; Webster, Rebecca A.; Wells, Timothy; McCarthy, James S.; Barber, Bridget E.; Marquart, Louise; Boyle, Michelle J.; Engwerda, Christian R.; Chalon, Stephan
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

合成过氧化物抗疟药OZ439的细胞色素P450-Mediated代谢和CYP抑制

ACS INFECTIOUS DISEASES
IF3.8
2021-06-085
OAAI
Shackleford, David M.; Chiu, Francis C. K.; Katneni, Kasiram; Blundell, Scott; McLaren, Jenna; Wang, Xiaofang; Zhou, Lin; Sriraghavan, Kamaraj; Alker, Andre M.; Hunziker, Daniel; Scheurer, Christian; Zhao, Qingjie; Dong, Yuxiang; Moehrle, Joerg J.; Abla, Nada; Matile, Hugues; Wittlin, Sergio; Vennerstrom, Jonathan L.; Charman, Susan A.
Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial
LANCET INFECTIOUS DISEASES
IF31
2020-08-0145
OAAI
Gaur, Aditya H.; McCarthy, James S.; Panetta, John C.; Dallas, Ronald H.; Woodford, John; Tang, Li; Smith, Amber M.; Stewart, Tracy B.; Branum, Kristen C.; Freeman, Burgess B., III; Patel, Nehali D.; John, Elizabeth; Chalon, Stephan; Ost, Shelley; Heine, Ryan N.; Richardson, Julie L.; Christensen, Robbin; Flynn, Patricia M.; Van Gessel, Yvonne; Mitasev, Branko; Moehrle, Joerg J.; Gusovsky, Fabian; Bebrevska, Lidiya; Guy, R. Kiplin
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048
CLINICAL INFECTIOUS DISEASES
IF7.3
2020-04-0231
OAAI
McCarthy, James S.; Donini, Cristina; Chalon, Stephan; Woodford, John; Marquart, Louise; Collins, Katharine A.; Rozenberg, Felix D.; Fidock, David A.; Cherkaoui-Rbati, Mohammed H.; Gobeau, Nathalie; Moehrle, Joerg J.
Efficacy and Safety of Fosmidomycin-Piperaquine as Nonartemisinin-Based Combination Therapy for Uncomplicated Falciparum Malaria: A Single-Arm, Age De-escalation Proof-of-Concept Study in Gabon
CLINICAL INFECTIOUS DISEASES
IF7.3
2017-12-2639
OAAI
Mombo-Ngoma, Ghyslain; Remppis, Jonathan; Sievers, Moritz; Manego, Rella Zoleko; Endamne, Lilian; Kabwende, Lumeka; Veletzky, Luzia; The Trong Nguyen; Groger, Mirjam; Lotsch, Felix; Mischlinger, Johannes; Flohr, Lena; Kim, Johanna; Cattaneo, Chiara; Hutchinson, David; Duparc, Stephan; Moehrle, Joerg; Velavan, Thirumalaisamy P.; Lell, Bertrand; Ramharter, Michael; Adegnika, Ayola Akim; Mordmueller, Benjamin; Kremsner, Peter G.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling
PLOS MEDICINE
IF9.9
2016-10-0436
OAAI
Le Bihan, Amelie; de Kanter, Ruben; Angulo-Barturen, Inigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J.; Delves, Michael; Ewerlingl, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo-Benito, Francisco Javier; Gnadig, Nina F.; Heidmann, Bibia; Belen Jimenez-Diaz, Maria; Leroy, Didier; Santos Martinez, Maria; Meyer, Solange; Moehrle, Joerg J.; Ng, Caroline L.; Noviyanti, Rintis; Ruecker, Andrea; Maria Sanz, Laura; Sauerwein, Robert W.; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N.; Weller, Thomas; Fischli, Walter; Fidock, David A.; Clozel, Martine; Wittlin, Sergio
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2016-06-0136
OAAI
McCarthy, James S.; Marquart, Louise; Sekuloski, Silvana; Trenholme, Katharine; Elliott, Suzanne; Griffin, Paul; Rockett, Rebecca; O'Rourke, Peter; Sloots, Theo; Angulo-Barturen, Iigo; Ferrer, Santiago; Jimenez-Diaz, Maria Belen; Martinez, Maria-Santos; van Huijsduijnen, Rob Hooft; Duparc, Stephan; Leroy, Didier; Wells, Timothy N. C.; Baker, Mark; Moehrle, Joerg J.

研究方向

暂未获取到该数据
J
James McCarthy
H 指数:87论文数:623被引数:2.4万
S
Stephan Duparc
H 指数:41论文数:123被引数:6,225
S
Stephan Chalon
H 指数:28论文数:74被引数:2,565
L
Louise Marquart
H 指数:36论文数:159被引数:3,826
S
Sergio Wittlin
H 指数:49论文数:250被引数:8,905
N
Nada Abla
H 指数:16论文数:40被引数:1,255
N
Nathalie Gobeau
H 指数:14论文数:34被引数:765
T
Timothy N. C. Wells
H 指数:82论文数:328被引数:2.5万
G
Grennady Wirjanata
H 指数:19论文数:58被引数:2,317
K
Katharine A. Collins
H 指数:31论文数:100被引数:3,699