Juha R. Savinainen

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression (vol 26,85,2025)

IF7.9

2025-05-120

AKU-005抑制内源性大麻素水解酶MAGL、FAAH和ABHD6，可降低离体皮质扩散性抑制（vol 26,85,2025）

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression

IF7.9

2025-05-120

AKU-005通过抑制内源性大麻素水解酶MAGL、FAAH和ABHD6，降低了离体条件下皮层扩散性抑制的发生。

5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions

IF7.9

2025-04-230

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-03-282

OAAI

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6)

IF7.9

2023-04-117

OAAI

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-143

PRE

Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

IF4.7

2020-06-017

PREAI

BIOLOGICAL PROCEDURES ONLINE

IF4.3

2020-03-157

OAAI

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

DRUG DISCOVERY TODAY

IF7.5

2020-02-0113

PREAI

Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-11-139

OAAI

Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors

自分泌运动因子抑制剂2，4-二氢吡喃并 [2，3-c] 吡唑衍生物的设计、合成及生物学评价

Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL)

IF4.7

2017-09-0111

PREAI

In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048)

IF5.9

2017-08-0123

OAAI

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2016-10-0118

OAAI

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11)

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

IF4.7

2016-10-0111

PREAI

Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors

IF5.9

2016-01-0125

PREAI

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2015-10-0111

PREAI

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity

IF4.7

2015-09-0124

PREAI

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands

IF5.9

2015-06-0143

OAAI