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Discovery of benzyl carbamate inhibitors of coronavirus Mpro enzymes from a legacy collection of cysteine protease inhibitors 从半胱氨酸蛋白酶抑制剂的馆藏库中发现苯甲氧羰酰基抑制冠状病毒Mpro酶的抑制剂 Sa Magalhaes Serafim, Mateus; Kronenberger, Thales; Francisco, Karol R.; De Sousa Reis, Erik Vinicius; Goncalves De Oliveira, Ellen; Marcelino E Oliveira, Fernanda Kelly; Serraglio Fortes, Isadora; Maciel Fernandes, Thais Helena; Barbosa Da Silva, Elany; Fajtova, Pavla; Skinner, Danielle E.; Syed, Rafay O.; Lage De Siqueira-Neto, Jair; Poso, Antti; Fernandes Mota, Bruno Eduardo; Alves Coelho-dos-Reis, Jordana Grazziela; Santos Abrahao, Jonatas; Goncalves Maltarollo, Vinicius; O'donoghue, Anthony J.; Caffrey, Conor R. 分享 收藏
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Activation of steroid hormone receptors by metabolism-disrupting chemicals Pitkanen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A.; Palvimo, Jorma J.; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Kublbeck, Jenni; Honkakoski, Paavo 分享 收藏
The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism Reetz, Leonie; Schulze, Lukas; Kronenberger, Thales; Selim, Khaled A.; Schaefle, Timm; Dema, Taulant; Zipperer, Alexander; Moessner, Jens; Poso, Antti; Grond, Stephanie; Peschel, Andreas; Krismer, Bernhard 分享 收藏
The comprehensive SARS-CoV-2 'hijackome' knowledge base Huuskonen, Sini; Liu, Xiaonan; Pohner, Ina; Redchuk, Taras; Salokas, Kari; Lundberg, Rickard; Maljanen, Sari; Belik, Milja; Reinholm, Arttu; Kolehmainen, Pekka; Tuhkala, Antti; Tripathi, Garima; Laine, Pia; Belanov, Sergei; Auvinen, Petri; Vartiainen, Maria; Keskitalo, Salla; Osterlund, Pamela; Laine, Larissa; Poso, Antti; Julkunen, Ilkka; Kakkola, Laura; Varjosalo, Markku 分享 收藏
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Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts 在心脏微环境中靶向亲环素A可保留衰竭心脏的心脏功能和结构 Sigle, Manuel; Rohlfing, Anne-Katrin; Cruz Santos, Melanie; Kopp, Timo; Krutzke, Konstantin; Gidlund, Vincent; Kollotzek, Ferdinand; Marzi, Julia; von Ungern-Sternberg, Saskia; Poso, Antti; Heikenwaelder, Mathias; Schenke-Layland, Katja; Seizer, Peter; Moellmann, Julia; Marx, Nikolaus; Feil, Robert; Feil, Susanne; Lukowski, Robert; Borst, Oliver; Schaeffer, Tilman E.; Mueller, Karin Anne Lydia; Gawaz, Meinrad P.; Heinzmann, David 分享 收藏
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships Asquith, Christopher R. M.; East, Michael P.; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I.; Axtman, Alison D.; Drewry, David H.; Tizzard, Graham J.; Poso, Antti; Willson, Timothy M.; Johnson, Gary L. 分享 收藏
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol 填补空白: 支链4-壬基酚异构体负责壬基酚对组成性雄烷受体 (CAR) 的激活 Rashidian, Azam; Dusek, Jan; Drastik, Martin; Smutna, Lucie; Fritsche, Kristin; Braeuning, Albert; Pijnenburg, Dirk; van Beuningen, Rinie; Honkakoski, Paavo; Poso, Antti; Kronenberger, Thales; Pavek, Petr 分享 收藏
Development and characterization of kinase sparing TPX2-tethering Aurora kinase A ligands for cancer therapy Moschopoulou, Athina Anastasia; Henning, Melanie; Wagner, Benedikt; Flotgen, Dirk; Reiner, Juliander; Skliarenko, Yulia; Zwirner, Stefan; Hinterleitner, Clemens; Seehawer, Marco; dArtista, Luana; Rist, Elke; Pantsar, Tatu; Kronenberger, Thales; Dauch, Daniel; Gehring-Khav, Corinna; Poso, Antti; Andreeva, Liudmila; Schwab, Matthias; Forster, Michael; Albrecht, Wolfgang; Laufer, Stefan; Zender, Lars 分享 收藏
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors Rak, Marcel; Menge, Amelie; Tesch, Roberta; Berger, Lena M.; Balourdas, Dimitrios-Ilias; Shevchenko, Ekaterina; Kramer, Andreas; Elson, Lewis; Berger, Benedict-Tilman; Abdi, Ismahan; Wahl, Laurenz M.; Poso, Antti; Kaiser, Astrid; Hanke, Thomas; Kronenberger, Thales; Joerger, Andreas C.; Muller, Susanne; Knapp, Stefan 分享 收藏
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors Wittlinger, Florian; Ogboo, Blessing C.; Shevchenko, Ekaterina; Damghani, Tahereh; Pham, Calvin D.; Schaeffner, Ilse K.; Oligny, Brandon T.; Chitnis, Surbhi P.; Beyett, Tyler S.; Rasch, Alexander; Buckley, Brian; Urul, Daniel A.; Shaurova, Tatiana; May, Earl W.; Schaefer, Erik M.; Eck, Michael J.; Hershberger, Pamela A.; Poso, Antti; Laufer, Stefan A.; Heppner, David E. 分享 收藏
The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma Spahn, Stephan; Kleinhenz, Fabian; Shevchenko, Ekaterina; Stahl, Aaron; Rasen, Yvonne; Geisler, Christine; Ruhm, Kristina; Klaumuenzer, Marion; Kronenberger, Thales; Laufer, Stefan A.; Sundberg-Malek, Holly; Bui, Khac Cuong; Horger, Marius; Biskup, Saskia; Schulze-Osthoff, Klaus; Templin, Markus; Malek, Nisar P.; Poso, Antti; Bitzer, Michael 分享 收藏
Aminopyrimidine Derivatives as Multiflavivirus Antiviral Compounds Identified from a Consensus Virtual Screening Approach 从共识虚拟筛选方法中鉴定出氨基嘧啶衍生物作为多黄病毒抗病毒化合物 Serafim, Mateus Sa Magalhaes; Kronenberger, Thales; Rocha, Rafael Eduardo Oliveira; Rosa, Amanda Del Rio Abreu; Mello, Thaysa Lara Goncalves; Poso, Antti; Ferreira, Rafaela Salgado; Abrahao, Jonatas Santos; Kroon, Erna Geessien; Mota, Bruno Eduardo Fernandes; Maltarollo, Vinicius Goncalves 分享 收藏
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