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Vassilis J. Demopoulos

Aristotle University of Thessaloniki

H指数:22

被引数:1,672

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Glutathione-Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells' Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis

谷胱甘肽-血红素/血红素加合物的形成可分解人K562细胞和红细胞的溶血产物中的细胞毒性氧化剂血红素/血红素: 谷胱甘肽对溶血性疾病和体内平衡的影响

IF6.6

2022-09-308

OAAI

Drug-like Properties and Fraction Lipophilicity Index as a combined metric

IF4.3

2021-10-0824

OAAI

Formation of novel N-acetylcysteine-hemin adducts abrogates hemin- induced cytotoxicity and suppresses the NRF2-driven stress response in human pro-erythroid K562 cells

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2020-08-0111

PREAI

Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2014-04-0123

PRE

Development of aldose reductase inhibitors for the treatment of inflammatory disorders

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2013-10-0342

PREAI

Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: Some structural aspects for aldose reductase inhibitory activity and selectivity

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2013-02-0121

PRE

Novel aldose reductase inhibitors: a patent survey (2006-present)

EXPERT OPINION ON THERAPEUTIC PATENTS

IF4.6

2012-09-2447

PREAI

Bis-pyrrolyl-tetrazolyl derivatives as hybrid polar compounds: A case of lipophilic functional bioisosterism with bis-acetamides

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2012-04-014

PREAI

Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2011-02-0125

PRE

A Diverse Series of Substituted Benzenesulfonamides as Aldose Reductase Inhibitors with Antioxidant Activity: Design, Synthesis, and in Vitro Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-10-1156

PREAI

Toward the Development of Innovative Bifunctional Agents To Induce Differentiation and To Promote Apoptosis in Leukemia: Clinical Candidates and Perspectives

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-07-2026

PRE

RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease

愤怒: 一种多配体受体揭示了健康和疾病的新见解

CURRENT MEDICINAL CHEMISTRY

IF3.5

2010-07-01150

PREAI

Evaluation of aldose reductase inhibition and docking studies of 6′-nitro and 6′,6-dinitrorosmarinic acids

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2010-04-0115

PREAI

Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2010-03-0168

PRE

Aldose Reductase Enzyme and its Implication to Major Health Problems of the 21st Century

CURRENT MEDICINAL CHEMISTRY

IF3.5

2009-02-01219

PREAI

Pyrrolylbenzothiazole derivatives as aldose reductase inhibitors

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2008-09-3022

PREAI

Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2008-05-0159

PRE

Design and synthesis of N-( 3,5-difluoro-4-hydroxyphenyl) benzenesulfonamides as aldose reductase inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2008-04-0120

PRE

Inhibitory effect of polar oregano extracts on aldose reductase and soybean lipoxygenase in vitro

极性牛至提取物对醛糖还原酶和大豆脂氧合酶的体外抑制作用

PHYTOTHERAPY RESEARCH

IF6.3

2006-05-1113

PREAI

Permeability characteristics of novel aldose reductase inhibitors using rat jejunum in vitro

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2006-05-0119

PREAI