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Ulf Madsen

University of Copenhagen

H指数:30

被引数:3,050

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Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2014-10-016

PREAI

Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

NEUROCHEMICAL RESEARCH

IF3.8

2014-05-226

PREAI

Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators

MOLECULAR PHARMACOLOGY

IF3

2012-11-0135

PREAI

Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators

负变构mGluR5调节剂的结构-活性关系

IF3.4

2012-01-2020

PREAI

Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

新的基于异恶唑啉的酸性氨基酸的合成及其对离子型谷氨酸受体的亲和力和选择性的研究

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2011-02-0122

PREAI

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

IF3.4

2010-07-2723

PREAI

Studies of the antagonist actions of (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazoly]propionic acid (ATPO) on non-NMDA receptors in cultured rat neurones

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-02-173

OAAI

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-03-1434

PREAI

Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2007-08-0128

PREAI

Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5 - Structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-08-0151

OAAI

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid:: Synthesis and pharmacology at glutamate receptors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2007-05-0112

PRE

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2005-09-1344

PREAI

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists:: Synthesis, modelling and molecular pharmacology

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2005-09-0111

PRE

Bioisosteric modifications of 2-arylureidobenzoic acids: Selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-12-0253

PREAI

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-12-0223

PREAI

Analogues of homoibotenic acid show potent and selective activity following sensitisation by quisqualic acid

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2004-03-014

PREAI

Ibotenic acid and thioibotenic acid:: a remarkable difference in activity at group III metabotropic glutamate receptors

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2004-02-0147

PREAI

2-arylureidobenzoic acids: Selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2003-11-2033

PREAI

Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2003-10-0113

PREAI

Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2003-05-2933

PREAI