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D

David E. Thurston

King's College London
H指数:45
被引数:7,111
浏览量:0

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An antibody-drug conjugate designed through clone and isotype selection restricts the growth of CSPG4-expressing triple-negative breast cancer

通过克隆和亚型筛选设计的抗体药物偶联物可抑制表达CSPG4的三阴性乳腺癌的生长。

npj Precision Oncology
IF8
2026-03-070
OAAI
Benjamina Esapa; Yi Liu; Alicia M. Chenoweth; Katie Stoker; Natalia Łabędź; Pablo Romero-Clavijo; Kristina M. Ilieva; Jennifer Trendell; Blanca Navarro-Llinas; Erin Suriawinata; Tobias Butcher; Ning Wang; Melanie Grandits; Lais C. G. F. Palhares; Alexandra McCraw; Silvia Crescioli; Annelie Johansson; Sheeba Irshad; Anita Grigoriadis; Patrycja Gazinska; Sophia Tsoka; Vijay Chudasama; James R. Baker; Andrew N. J. Tutt; Anthony Cheung; David E. Thurston; Sophia N. Karagiannis
Synthesis, SAR and Biophysical Mechanism of Action of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) Guanine-Adenine DNA Cross-Linking Agents

环丙烷苯并吲哚-吡啶苯并二氮杂-CBI-PDD鸟嘌呤-腺嘌呤DNA交联剂的合成、构效关系及生物物理作用机制

European Journal of Medicinal Chemistry
IF5.9
2025-09-260
PRE
George Procopiou; Paul J.M. Jackson; Daniella di Mascio; Jennifer L. Auer; Paolo Andriollo; Ilona Pysz-Hosey; Julia Mantaj; Khondaker Miraz Rahman; Keith R. Fox; David E. Thurston
Synthesis and Evaluation of DNA Cross-linkers by Click Chemistry-Mediated Heterodimerization of Nor-Tomaymycins

通过点击化学介导的诺托-汤姆霉素异二聚化合成与评价DNA交联剂

Chemistry – A European Journal
IF3.7
2025-08-220
OAAI
Dr. Julia Friederich; Dr. Katharina Rox; Dr. Hazel L. S. Fuchs; Dr. Md. Mahbub Hasan; Patrick Raunft; Prof. Dr. David E. Thurston; Prof. Dr. Keith R. Fox; Prof. Dr. Khondaker Miraz Rahman; Prof. Dr. Mark Brönstrup
A novel DNA sequence-selective, guanine mono-alkylating ADC payload suitable for solid tumour treatment

一种新型的DNA序列选择性鸟嘌呤单烷基化ADC载荷，适用于实体瘤治疗

RSC MEDICINAL CHEMISTRY
IF3.6
2025-01-010
OA
Andriollo, Paolo; di Mascio, Daniella; Jackson, Paul J. M.; Hasan, Md. Mahbub; Pysz-Hosey, Ilona; Procopiou, George; Fox, Keith R.; Rahman, Khondaker Miraz; Thurston, David E.
DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies
COMMUNICATIONS BIOLOGY
IF5.1
2022-07-292
OAAI
Procopiou, George; Jackson, Paul J. M.; di Mascio, Daniella; Auer, Jennifer L.; Pepper, Chris; Rahman, Khondaker Miraz; Fox, Keith R.; Thurston, David E.
Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs)
SCIENTIFIC REPORTS
IF3.9
2020-06-0115
OAAI
Hoffmann, Ricarda M.; Mele, Silvia; Cheung, Anthony; Larcombe-Young, Daniel; Bucaite, Gintare; Sachouli, Eirini; Zlatareva, Iva; Morad, Hassan O. J.; Marlow, Rebecca; McDonnell, James M.; Figini, Mariangela; Lacy, Katie E.; Tutt, Andrew J. N.; Spicer, James F.; Thurston, David E.; Karagiannis, Sophia N.; Crescioli, Silvia
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit nuclear factor-KB activity and synergize with bortezomib and ibrutinib in hematologic cancers
HAEMATOLOGICA
IF7.9
2020-05-076
OAAI
Lewis, Thomas; Corcoran, David B.; Thurston, David E.; Giles, Peter J.; Ashelford, Kevin; Walsby, Elisabeth J.; Fegan, Christopher D.; Pepper, Andrea G. S.; Rahman, Khondaker Miraz; Pepper, Chris
A new low potency DNA guanine monoalkylating ADC payload with enhanced in vivo tolerability
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-12-010
PRE
Veillard, Nicolas; Andriollo, Paolo; Cascio, Francesco; Jackson, Paul J. M.; Thurston, David E.
IKS01, a next generation antibody drug conjugate, shows target-dependent efficacy in a platinum-resistant tumor model with low levels of folate receptor α expression
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-12-010
PRE
Thirlway, Jenny; Lodge, Adam; Pelava, Andria; Williamson, Daniel J.; Carta, Davide; Al Nakeeb, Majid; Mysliwy, Justyna; Jackson, Paul J. M.; Thurston, David E.; Lutz, Robert J.
Effect of C8-side chain on the cytotoxicity and NF-kB inhibitory capacity of pyrrolobenzodiazepines
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Corcoran, David B.; Lewis, Thomas; Nahar, Kazi S.; Fegan, Christopher; Pepper, Chris; Thurston, David E.; Rahman, Khondaker Miraz
A new class of sequence-selective DNA cross-linking ADC payloads with increased in vivotolerability
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Procopiou, George; Auer, Jennifer; di Mascio, Daniella; Fox, Keith R.; Andriollo, Paolo; Pysz, Ilona; Cascio, Francesco; Veillard, Nicolas; Rahman, K. Miraz; Jackson, Paul J.; Thurston, David E.
Development of a rapid and efficient methodology to quantitate thiol detection in antibody-drug conjugates (ADCs)
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Pysz, Ilona; Andriollo, Paolo; Jackson, Paul J.; Rahman, K. M.; Thurston, David E.
Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-01-2817
OAAI
Corcoran, David B.; Lewis, Thomas; Nahar, Kazi S.; Jamshidi, Shirin; Fegan, Christopher; Pepper, Chris; Thurston, David E.; Rahman, Khondaker Miraz.
Topical delivery of anthramycin II. Influence of binary and ternary solvent systems
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
IF4.7
2018-08-0116
OAAI
Haque, Tasnuva; Rahman, Khondaker Miraz; Thurston, David E.; Hadgraft, Jonathan; Lane, Majella E.
Development and evaluation of T-Zap: a novel antibody-drug conjugate for the treatment of Her2 positive breast cancer
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Hoffmann, Ricarda M.; Crescioli, Silvia; Thurston, David E.; Karagiannis, Sophia N.
Development of an HPLC method for the assessment of hydrophobicity of ADC payloads
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Pysz, Ilona; Jackson, Paul J.; Rahman, Khondaker M.; Thurston, David E.
Pyridinobenzodiazepines (PDDs): A new class of sequence-selective DNA mono-alkylating ADC payloads with low hydrophobicity
CANCER RESEARCH
IF16.6
2018-07-013
PRE
Veillard, Nicolas; Andriollo, Paolo; Mantaj, Julia; Fox, Keith R.; Rahman, K. Miraz; Procopiou, George; Cascio, Francesco; Corcoran, David B.; Pysz, Ilona; Cooper, Patricia A.; Shnyder, Steven D.; Ju, Yawen; Tan, Edwin; Schopperle, William M.; Jackson, Paul J.; Thurston, David E.
Fragment-based approach to develop small-molecule STAT3 transcription factor inhibitors
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-01-010
PRE
Nahar, Kazi S.; Jamshidi, Shirin; Thurston, David E.; Rahman, Khondaker Miraz
Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)
ONCOIMMUNOLOGY
IF6.3
2017-11-20129
OAAI
Hoffmann, Ricarda M.; Coumbe, Ben G. T.; Josephs, Debra H.; Mele, Silvia; Ilieva, Kristina M.; Cheung, Anthony; Tutt, Andrew N.; Spicer, James F.; Thurston, David E.; Crescioli, Silvia; Karagiannis, Sophia N.
Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA
BIOPHYSICAL CHEMISTRY
IF2.2
2017-11-015
OAAI
Basher, Mohammad A.; Rahman, Khondaker Miraz; Jackson, Paul J. M.; Thurston, David E.; Fox, Keith R.

研究方向

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C
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