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Prostate cancer RIPTAC™ therapeutics demonstrate activity in preclinical models of Enzalutamide-resistant prostate cancer Yu, Xinheng; Eastman, Kyle J.; Raina, Kanak; Jones, Kelli M.; Forbes, Chris D.; Hundt, Abigail; Garcia, Marco; Stronk, Rebecca; Howard, Katia; McGovern, Andrew; Chenard, Rebekka; Denny, Allison; Forgione, Mia; Bassoli, Kyle; Garvin, Ethan; Mousseau, James J.; Li, Hao; King, Madeline P.; Bhardwaj, Amit; Kayser-Bricker, Katherine J.; Crews, Craig M. 分享 收藏
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies Easton, Amy; Jensen, Marianne L.; Wang, Congwei; Hagedorn, Peter H.; Li, Yuwen; Weed, Michael; Meredith, Jere E.; Guss, Valerie; Jones, Kelli; Gill, Martin; Krause, Carol; Brown, Jeffrey M.; Hunihan, Lisa; Natale, Joanne; Fernandes, Alda; Lu, Yifeng; Polino, Joe; Bookbinder, Mark; Cadelina, Greg; Benitex, Yulia; Sane, Ramola; Morrison, John; Drexler, Dieter; Mercer, Stephen E.; Bon, Charlotte; Pandya, Nikhil J.; Jagasia, Ravi; Yang, Tai-Hsien Ou; Distler, Tania; Grueninger, Fiona; Meldgaard, Michael; Terrigno, Marco; Macor, John E.; Albright, Charles F.; Loy, James; Hoeg, Anja M.; Olson, Richard E.; Cacace, Angela M. 分享 收藏
Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features Hagedorn, Peter H.; Brown, Jeffrey M.; Easton, Amy; Pierdomenico, Maria; Jones, Kelli; Olson, Richard E.; Mercer, Stephen E.; Li, Dong; Loy, James; Hog, Anja M.; Jensen, Marianne L.; Gill, Martin; Cacace, Angela M. 分享 收藏
TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor Jo, Ukhyun; Murai, Yasuhisa; Agama, Keli K.; Sun, Yilun; Saha, Liton Kumar; Yang, Xi; Arakawa, Yasuhiro; Gayle, Sophia; Jones, Kelli; Paralkar, Vishwas; Sundaram, Ranjini K.; Van Doorn, Jinny; Vasquez, Juan C.; Bindra, Ranjit S.; Choi, Woo Suk; Pommier, Yves 分享 收藏
Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity (vol 3,zcab021, 2021) Gayle, Sophia; Aiello, Robert; Leelatian, Nalin; Beckta, Jason M.; Bechtold, Jane; Bourassa, Patricia; Csengery, Johanna; Maguire, Robert J.; Marshall, Dan; Sundaram, Ranjini K.; Van Doorn, Jinny; Jones, Kelli; Moore, Hunter; Lopresti-Morrow, Lori; Paradis, Timothy; Tylaska, Laurie; Zhang, Qing; Visca, Hannah; Reshetnyak, Yana K.; Andreev, Oleg A.; Engelman, Donald M.; Glazer, Peter M.; Bindra, Ranjit S.; Paralkar, Vishwas M. 分享 收藏
CBX-12 (alphalex™-exatecan) sensitizes tumors to immune checkpoint blockade in an antigen agnostic manner by immune activation Gayle, Sophia; Vasquez, Juan; Paradis, Timothy; Jones, Kelli; Sundaram, Ranjini; van Doorn, Jinny; Muthusamy, Viswanathan; Bindra, Ranjit S.; Aiello, Robert J.; Paralkar, Vishwas 分享 收藏
Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity Gayle, Sophia; Aiello, Robert; Leelatian, Nalin; Beckta, Jason M.; Bechtold, Jane; Bourassa, Patricia; Csengery, Johanna; Maguire, Robert J.; Marshall, Dan; Sundaram, Ranjini K.; Van Doorn, Jinny; Jones, Kelli; Moore, Hunter; Lopresti-Morrow, Lori; Paradis, Timothy; Tylaska, Laurie; Zhang, Qing; Visca, Hannah; Reshetnyak, Yana K.; Andreev, Oleg A.; Engelman, Donald M.; Glazer, Peter M.; Bindra, Ranjit S.; Paralkar, Vishwas M. 分享 收藏
CBX-12: A low pH targeting alphalex™-exatecan conjugate for the treatment of solid tumors Aiello, Robert J.; Gayle, Sophia; Bechtold, Jane; Bourassa, Patricia; Csengery, Johanna; Deshpande, Ketaki; Jones, Kelli; Lopresti-Morrow, Lori; Maguire, Robert; Marshall, Dan; Moore, Hunter; Paradis, Timothy; Tylaska, Laurie; Zhang, Qing; Volkmann, Robert; Bindra, Ranjit S.; Glazer, Peter M.; Paralkar, Vishwas 分享 收藏
Development of alphalex™-toxin low pH targeting conjugates for the treatment of solid tumors Gayle, Sophia; Aiello, Robert; Bechtold, Jane; Bourassa, Patricia; Csengery, Johanna; Deshpande, Ketaki; Jones, Kelli; Lopresti-Morrow, Lori; Maguire, Robert; Marshall, Dan; Moore, Hunter; Paradis, Timothy; Tylaska, Laurie; Zhang, Qing; Volkmann, Robert; Bindra, Ranjit S.; Glazer, Peter M.; Paralkar, Vishwas 分享 收藏
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents Pieschl, Rick L.; Miller, Regina; Jones, Kelli M.; Post-Munson, Debra J.; Chen, Ping; Newberry, Kimberly; Benitex, Yulia; Molski, Thaddeus; Morgan, Daniel; McDonald, Ivar M.; Macor, John E.; Olson, Richard E.; Asaka, Yukiko; Digavalli, Siva; Easton, Amy; Herrington, James; Westphal, Ryan S.; Lodge, Nicholas J.; Zaczek, Robert; Bristow, Linda J.; Li, Yu-Wen 分享 收藏
Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure - Activity Relationship Cook, James; Zusi, F. Christopher; McDonald, Ivar M.; King, Dalton; Hill, Matthew D.; Iwuagwu, Christiana; Mate, Robert A.; Fang, Haiquan; Zhao, Rulin; Wang, Bei; Cutrone, Jingfang; Ma, Baoqing; Gao, Qi; Knox, Ronald J.; Matchett, Michele; Gallagher, Lizbeth; Ferrante, Meredith; Post-Munson, Debra; Molski, Thaddeus; Easton, Amy; Miller, Regina; Jones, Kelli; Digavalli, Siva; Healy, Francine; Lentz, Kimberley; Benitex, Yulia; Clarke, Wendy; Natale, Joanne; Siuciak, Judith A.; Lodge, Nicholas; Zaczek, Robert; Denton, Rex; Morgan, Daniel; Bristow, Linda J.; Macor, John E.; Olson, Richard E. 分享 收藏
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5 mGluR5的有效正变构调节剂BMS-955829的发现和临床前评估 Yang, Fukang; Snyder, Lawrence B.; Balakrishnan, Anand; Brown, Jeffrey M.; Sivarao, Digavalli V.; Easton, Amy; Fernandes, Alda; Gulianello, Michael; Hanumegowda, Umesh M.; Huang, Hong; Huang, Yanling; Jones, Kelli M.; Li, Yu-Wen; Matchett, Michele; Mattson, Gail; Miller, Regina; Santone, Kenneth S.; Senapati, Arun; Shields, Eric E.; Simutis, Frank J.; Westphal, Ryan; Whiterock, Valerie J.; Bronson, Joanne J.; Macor, John E.; Degnan, Andrew P. 分享 收藏
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P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice Meredith, Jere E., Jr.; Thompson, Lorin A.; Toyn, Jeremy H.; Marcin, Lawrence; Barten, Donna M.; Marcinkeviciene, Jovita; Kopcho, Lisa; Kim, Young; Lin, Alan; Guss, Valerie; Burton, Catherine; Iben, Lawrence; Polson, Craig; Cantone, Joe; Ford, Michael; Drexler, Dieter; Fiedler, Tracey; Lentz, Kimberley A.; Grace, James E., Jr.; Kolb, Janet; Corsa, Jason; Pierdomenico, Maria; Jones, Kelli; Olson, Richard E.; Macor, John E.; Albright, Charles F. 分享 收藏
Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping Lindner, Mark D.; Hogan, John B.; Hodges, Donald B., Jr.; Orie, Anitra F.; Chen, Ping; Corsa, Jason A.; Leet, John E.; Gillman, Kevin W.; Rose, Gregory M.; Jones, Kelli M.; Gribkoff, Valentin K. 分享 收藏
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