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Y

Yi Chen

Shanghai Institute of Materia Medica
H指数:38
被引数:4,715

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Low-dose antiangiogenic multikinase inhibitor AL3810 synergizes with PD-1 blockade by reducing CSF1-driven MHC-IIint tumour-associated macrophages to optimize TIM-3+ CD8+ T-cell effector function

低剂量抗血管生成多靶点激酶抑制剂AL3810通过减少CSF1驱动的MHC-II<sup>int</sup>肿瘤相关巨噬细胞，与PD-1阻断协同作用以优化TIM-3<sup>+</sup> CD8<sup>+</sup> T细胞效应功能

British Journal of Pharmacology
IF7.7
2026-09-290
PRE
Kun Fang; Wen-Xin Zhang; Zi-Han Li; Rong Wang; Yi-Ming Sun; Yi Su; Ying-Lei Gao; Min Yao; Jian Ding; Yi Chen; Yan-Fen Fang
Discovery of Novel Tridentate Alkenyl Diacid Derivatives as Potent ATP Citrate Lyase Inhibitors for the Treatment of Hepatocellular Carcinoma

新型三齿烯基二酸衍生物作为强效ATP柠檬酸裂合酶抑制剂在治疗肝细胞癌中的应用发现

Journal of Medicinal Chemistry
IF6.8
2025-07-160
PRE
Yurou Yang; Jimao Zhai; Fan Wang; Gaolei Song; Honghong Xu; Xinyu Sun; Qingbo Zhang; Jie Ma; Min Gu; Yinglei Gao; Mei Zhang; Jian Ding; Yi Chen; Jingya Li; Zhifu Xie; Yanfen Fang; Fajun Nan
Development of ASGR-Mediated Hepatocyte-Targeting Cytotoxic Drug Conjugates with CTSB-Cleavable Linkers Incorporating Succinimide and Succinic Acid Monoamide

基于ASGR介导的靶向肝细胞的细胞毒性药物偶联物的开发：整合琥珀酰亚胺和琥珀酸单酰胺的CTS B可切割连接子

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-02-070
PRE
Jiang, Jingsheng; Jian, Sigang; Lin, Feifei; Zhang, Zhuo; Shen, Qianqian; Long, Guozhang; Yang, Biyu; Lin, Junzhen; Fang, Yanfen; Ding, Jian; Liu, Jia; Chen, Yi
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas

发现新的BTK抑制剂S-016并确定治疗淋巴瘤 (包括BTK抑制剂耐药淋巴瘤) 的新策略

ACTA PHARMACOLOGICA SINICA
IF8.4
2024-06-040
PRE
Song, Pei-ran; Wan, Zhi-peng; Huang, Ge-ge; Song, Zi-lan; Zhang, Tao; Tong, Lin-jiang; Fang, Yan; Tang, Hao-tian; Xue, Yu; Zhan, Zheng-sheng; Feng, Fang; Li, Yan; Shi, Wen-hao; Huang, Yu-qing; Chen, Yi; Duan, Wen-hu; Ding, Jian; Zhang, Ao; Xie, Hua

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