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An electrophilic fragment screening for the development of small molecules targeting caspase-2 Cuellar, Matthew E.; Yang, Mu; Karavadhi, Surendra; Zhang, Ya-Qin; Zhu, Hu; Sun, Hongmao; Shen, Min; Hall, Matthew D.; Patnaik, Samarjit; Ashe, Karen H.; Walters, Michael A.; Pockes, Steffen 分享 收藏
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Reference compounds for characterizing cellular injury in high-content cellular morphology assays Dahlin, Jayme L.; Hua, Bruce K.; Zucconi, Beth E.; Nelson, Shawn D.; Singh, Shantanu; Carpenter, Anne E.; Shrimp, Jonathan H.; Lima-Fernandes, Evelyne; Wawer, Mathias J.; Chung, Lawrence P. W.; Agrawal, Ayushi; O'Reilly, Mary; Barsyte-Lovejoy, Dalia; Szewczyk, Magdalena; Li, Fengling; Lak, Parnian; Cuellar, Matthew; Cole, Philip A.; Meier, Jordan L.; Thomas, Tim; Baell, Jonathan B.; Brown, Peter J.; Walters, Michael A.; Clemons, Paul A.; Schreiber, Stuart L.; Wagner, Bridget K. 分享 收藏
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Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy Singh, Gurpreet; Liu, Peng; Yao, Katherine R.; Strasser, Jessica M.; Hlynialuk, Chris; Leinonen-Wright, Kailee; Teravskis, Peter J.; Choquette, Jessica M.; Ikramuddin, Junaid; Bresinsky, Merlin; Nelson, Kathryn M.; Liao, Dezhi; Ashe, Karen H.; Walters, Michael A.; Pockes, Steffen 分享 收藏
Nuisance compounds in cellular assays Dahlin, Jayme L.; Auld, Douglas S.; Rothenaigner, Ina; Haney, Steve; Sexton, Jonathan Z.; Nissink, J. Willem M.; Walsh, Jarrod; Lee, Jonathan A.; Strelow, John M.; Willard, Francis S.; Ferrins, Lori; Baell, Jonathan B.; Walters, Michael A.; Hua, Bruce K.; Hadian, Kamyar; Wagner, Bridget K. 分享 收藏
Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity Jackson, Paul A.; Schares, Henry A. M.; Jones, Katherine F. M.; Widen, John C.; Dempe, Daniel P.; Grillet, Francois; Cuellar, Matthew E.; Walters, Michael A.; Harki, Daniel A.; Brummond, Kay M. 分享 收藏
The Essential Medicinal Chemistry of Cannabidiol (CBD) Nelson, Kathryn M.; Bisson, Jonathan; Singh, Gurpreet; Graham, James G.; Chen, Shao-Nong; Friesen, J. Brent; Dahlin, Jayme L.; Niemitz, Matthias; Walters, Michael A.; Pauli, Guido F. 分享 收藏
Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation Shrimp, Jonathan H.; Jing, Yihang; Gamage, Supuni Thalalla; Nelson, Kathryn M.; Han, Joseph; Bryson, Keri M.; Montgomery, David C.; Thomas, Justin M.; Nance, Kellie D.; Sharma, Sunny; Fox, Stephen D.; Andressen, Thorkell; Sinclair, Wilson R.; Wu, Hong; Allali-Hassani, Abdellah; Senisterra, Guillermo; Vedadi, Masoud; Lafontaine, Denis; Dahlin, Jayme L.; Marmorstein, Ronen; Walters, Michael A.; Meier, Jordan L. 分享 收藏
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents 发现赖氨酸乙酰转移酶的酰基磺酰肼衍生抑制剂KAT6A作为有效的衰老诱导抗癌剂 Priebbenow, Daniel L.; Leaver, David J.; Nghi Nguyen; Cleary, Benjamin; Lagiakos, H. Rachel; Sanchez, Julie; Xue, Lian; Huang, Fei; Sun, Yuxin; Mujumdar, Prashant; Mudududdla, Ramesh; Varghese, Swapna; Teguh, Silvia; Charman, Susan A.; White, Karen L.; Shackleford, David M.; Katneni, Kasiram; Cuellar, Matthew; Strasser, Jessica M.; Dahlin, Jayme L.; Walters, Michael A.; Street, Ian P.; Monahan, Brendon J.; Jarman, Kate E.; Sabroux, Helene Jousset; Falk, Hendrik; Chung, Matthew C.; Hermans, Stefan J.; Downer, Natalie L.; Parker, Michael W.; Voss, Anne K.; Thomas, Tim; Baell, Jonathan B. 分享 收藏
Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors Xie, Yiyue; Tummala, Padmaja; Oakley, Aaron J.; Deora, Girdhar Singh; Nakano, Yuji; Rooke, Melissa; Cuellar, Matthew E.; Strasser, Jessica M.; Dahlin, Jayme L.; Walters, Michael A.; Casarotto, Marco G.; Board, Philip G.; Baell, Jonathan B. 分享 收藏
Improving natural product research translation: From source to clinical trial Sorkin, Barbara C.; Kuszak, Adam J.; Bloss, Gregory; Fukagawa, Naomi K.; Hoffman, Freddie Ann; Jafari, Mahtab; Barrett, Bruce; Brown, Paula N.; Bushman, Frederic D.; Casper, Steven J.; Chilton, Floyd H.; Coffey, Christopher S.; Ferruzzi, Mario G.; Hopp, D. Craig; Kiely, Mairead; Lakens, Daniel; MacMillan, John B.; Meltzer, David O.; Pahor, Marco; Paul, Jeffrey; Pritchett-Corning, Kathleen; Quinney, Sara K.; Rehermann, Barbara; Setchell, Kenneth D. R.; Sipes, Nisha S.; Stephens, Jacqueline M.; Taylor, D. Lansing; Tiriac, Herve; Walters, Michael A.; Xi, Dan; Zappala, Giovanna; Pauli, Guido F. 分享 收藏
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (vol 9, 9841, 2019) Selvaraju, Karthik; Mofers, Arjan; Pellegrini, Paola; Salomonsson, Johannes; Ahlner, Alexandra; Morad, Vivian; Hillert, Ellin-Kristina; Espinosa, Belen; Arner, Elias S. J.; Jensen, Lasse; Malmstrom, Jonas; Turkina, Maria V.; D'Arcy, Padraig; Walters, Michael A.; Sunnerhagen, Maria; Linder, Stig 分享 收藏
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death Bosnakovski, Darko; da Silva, Meiricris T.; Sunny, Sithara T.; Ener, Elizabeth T.; Toso, Erik A.; Yuan, Ce; Cui, Ziyou; Walters, Michael A.; Jadhav, Ajit; Kyba, Michael 分享 收藏
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system Selvaraju, Karthik; Mofers, Arjan; Pellegrini, Paola; Salomonsson, Johannes; Ahlner, Alexandra; Morad, Vivian; Hillert, Ellin-Kristina; Espinosa, Belen; Arner, Elias S. J.; Jensen, Lasse; Malmstrom, Jonas; Turkina, Maria V.; D'Arcy, Padraig; Walters, Michael A.; Sunnerhagen, Maria; Linder, Stig 分享 收藏
Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A Leaver, David J.; Cleary, Benjamin; Nghi Nguyen; Priebbenow, Daniel L.; Lagiakos, H. Rachel; Sanchez, Julie; Xue, Lian; Huang, Fei; Sun, Yuxin; Mujumdar, Prashant; Mudududdla, Ramesh; Varghese, Swapna; Teguh, Silvia; Charman, Susan A.; White, Karen L.; Katneni, Kasiram; Cuellar, Matthew; Strasser, Jessica M.; Dahlin, Jayme L.; Walters, Michael A.; Street, Ian P.; Monahan, Brendon J.; Jarman, Kate E.; Sabroux, Helene Jousset; Falk, Hendrik; Chung, Matthew C.; Hermans, Stefan J.; Parker, Michael W.; Thomas, Tim; Baell, Jonathan B. 分享 收藏
3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity Xue, Lian; Shi, Da-Hua; Harjani, Jitendra R.; Huang, Fei; Beveridge, Julia G.; Dingjan, Tamir; Ban, Kung; Diab, Sarah; Duffy, Sandra; Lucantoni, Leonardo; Fletcher, Sabine; Chiu, Francis C. K.; Blundell, Scott; Ellis, Katherine; Ralph, Stuart A.; Wirjanata, Grennady; Teguh, Silvia; Noviyanti, Rintis; Chavchich, Marina; Creek, Darren; Price, Ric N.; Marfurt, Jutta; Charman, Susan A.; Cuellar, Matthew E.; Strasser, Jessica M.; Dahlin, Jayme L.; Walters, Michael A.; Edstein, Michael D.; Avery, Vicky M.; Baell, Jonathan B. 分享 收藏
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