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L

László Őrfi

vichem chemie ltd

35H指数
197论文数
4.5K被引数
收录论文 64
发表时间
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Identification and Validation of an Inhibitor of the Protein Kinases PIM and DYRK鉴定和验证PIM和DYRK蛋白激酶的抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-03-18
err0
errOAAI
errGyula Bencze; Prabhadevi Venkataramani; Elad Elkayam; Keith D. Rivera; Ankur Garg; Istvan Szabadakai; Laszlo Orfi; Leemor Joshua-Tor; Darryl J. Pappin; Nicholas K. Tonks
err分享
err收藏
The role of PI3K-Akt-mTOR axis in Warburg effect and its modification by specific protein kinase inhibitors in human and rat inflammatory macrophages
errINTERNATIONAL IMMUNOPHARMACOLOGY
IF4.7
err2024-11-01
err0
errOAAI
errBogel, Gabor; Svab, Gergely; Muranyi, Jozsef; Szokol, Balint; Kukor, Zoltan; Kardon, Tamas; Orfi, Laszlo; Tretter, Laszlo; Hrabak, Andras
err分享
err收藏
CDK9 inhibition as an effective therapy for small cell lung cancer
errCELL DEATH & DISEASE
IF9.6
err2024-05-20
err1
errOAAI
errCapuccino, L. Valdez; Kleitke, T.; Szokol, B.; Svajda, L.; Martin, F.; Bonechi, F.; Kreko, M.; Azami, S.; Montinaro, A.; Wang, Y.; Nikolov, V.; Kaiser, L.; Bonasera, D.; Saggau, J.; Scholz, T.; Schmitt, A.; Beleggia, F.; Reinhardt, H. C.; George, J.; Liccardi, G.; Walczak, H.; Tovari, J.; Braegelmann, J.; Montero, J.; Sos, M. L.; Orfi, L.; Peltzer, N.
err分享
err收藏
Phosphoryl- or phosphinoyl-functionalized benzo[de]isoquinolinones: synthesis, experimental design, mechanism and biological activity
errREACTION CHEMISTRY & ENGINEERING
IF3.1
err2024-01-01
err0
PREAI
errRavai, Bettina; Popovics-Toth, Nora; Komka, Kinga; Csontos, Istvan; Szokol, Balint; Orfi, Zoltan; Orfi, Laszlo; Balint, Erika
err分享
err收藏
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-02-01
err4
errOAAI
errGarai, Janos; Radnai, Balazs; Vamos, Eszter; Kovacs, Dominika; Vantus, Viola Bagone; Rumbus, Zoltan; Pakai, Eszter; Garami, Andras; Gulyas-Fekete, Gergely; Agocs, Attila; Kreko, Marcell; Zaman, Khadiza; Prokai, Laszlo; Orfi, Laszlo; Jakus, Peter B.; Lorand, Tamas
err分享
err收藏
Decreasing effects of protein kinase inhibitors on the expression of NOS2 and inflammatory cytokines and on phagocytosis in rat peritoneal macrophages is partly related to repolarization br
errMOLECULAR IMMUNOLOGY
IF3
err2023-01-01
err3
errOAAI
errHrabak, Andras; Bogel, Gabor; Muranyi, Jozsef; Tamasi, Viola; Nemeth, Krisztina; Szokol, Balint; Kukor, Zoltan; Kardon, Tamas; Orfi, Laszlo
err分享
err收藏
HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2022-01-27
err8
errOAAI
errGomez, Valenti; Galazi, Myria; Weitsman, Gregory; Monypenny, James; Al-Salemee, Fahad; Barber, Paul R.; Ng, Kenrick; Beatson, Richard; Szokol, Balint; Orfi, Laszlo; Mullen, Greg; Vanhaesebroeck, Bart; Chowdhury, Simon; Leung, Hing Y.; Ng, Tony
err分享
err收藏
Production of NOS2 and inflammatory cytokines is reduced by selected protein kinase inhibitors with partial repolarization of HL-60 derived and human blood macrophages选择的蛋白激酶抑制剂可减少NOS2和炎性细胞因子的产生，并使HL-60来源的和人血巨噬细胞部分复极化
errHELIYON
IF3.6
err2022-01-01
err6
errOAAI
errBogal, Gabor; Muranyi, Jozsef; Szokol, Balint; Kukor, Zoltan; Mora, Istvan; Kardon, Tamas; Orfi, Laszlo; Hrabak, Andras
err分享
err收藏
Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice
errJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
IF5.4
err2021-07-06
err3
errOAAI
errGarai, Janos; Kreko, Marcell; Orfi, Laszlo; Jakus, Peter Balazs; Rumbus, Zoltan; Keringer, Patrik; Garami, Andras; Vamos, Eszter; Kovacs, Dominika; Bagone Vantus, Viola; Radnai, Balazs; Lorand, Tamas
err分享
err收藏
Inclusion complexation of the anticancer drug pomalidomide with cyclodextrins: fast dissolution and improved solubility抗癌药物pomalidomide与环糊精的包合物: 快速溶解和改善的溶解度
errHELIYON
IF3.6
err2021-07-01
err14
errOAAI
errSzabo, Zoltan-Istvan; Orban, Gyorgy; Borbas, Eniko; Csicsak, Dora; Kadar, Szabina; Fiser, Bela; Dobo, Mate; Horvath, Peter; Kiss, Eszter; Budai, Livia; Dobos, Judit; Palla, Tamas; Orfi, Laszlo; Volgyi, Gergely; Toth, Gergo
err分享
err收藏
Lyophilization and homogenization of biological samples improves reproducibility and reduces standard deviation in molecular biology techniques
errAMINO ACIDS
IF2.4
err2021-05-17
err34
errOAAI
errMolnar, Agnes; Lakat, Tamas; Hosszu, Adam; Szebeni, Beata; Balogh, Anna; Orfi, Laszlo; Szabo, Attila J.; Fekete, Andrea; Hodrea, Judit
err分享
err收藏
Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth (vol 10, 14174, 2020)
errSCIENTIFIC REPORTS
IF3.9
err2021-01-29
err1
errOAAI
errBencze, Gyula; Bencze, Szilvia; Rivera, Keith D.; Watson, James D.; Hidvegi, Mate; Orfi, Laszlo; Tonks, Nicholas K.; Pappin, Darryl J.
err分享
err收藏
Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth
errSCIENTIFIC REPORTS
IF3.9
err2020-08-25
err9
errOAAI
errBencze, Gyula; Bencze, Szilvia; Rivera, Keith D.; Watson, James D.; Orfi, Laszlo; Tonks, Nicholas K.; Pappin, Darryl J.
err分享
err收藏
Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2019-12-01
err12
PREAI
errBaska, Ferenc; Sipos, Anna; Orfi, Zoltan; Nemes, Zoltan; Dobos, Judit; Szantai-Kis, Csaba; Szabo, Eszter; Szenasi, Gabor; Dezsi, Laszlo; Hamar, Peter; Cserepes, Mihaly T.; Tovari, Jozsef; Garamvolgyi, Rita; Kreko, Marcell; Orfi, Laszlo
err分享
err收藏
Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2018-06-21
err26
PREAI
errSzabadkai, Istvan; Torka, Robert; Garamvolgyi, Rita; Baska, Ferenc; Gyulavari, Pal; Boros, Sandor; Illyes, Eszter; Choidas, Axel; Ullrich, Axel; Orfi, Laszlo
err分享
err收藏
DNA binding of sunitinib: Spectroscopic evidence via circular dichroism and nuclear magnetic resonance舒尼替尼的DNA结合: 通过圆二色性和核磁共振的光谱证据
errJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
err2018-02-01
err10
PREAI
errKiss, Eszter; Mirzahosseini, Arash; Hubert, Agnes; Ambrus, Attila; Orfi, Laszlo; Horvath, Peter
err分享
err收藏
Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma
errCELL REPORTS
IF6.9
err2017-09-01
err46
errOAAI
errBraegelmann, Johannes; Dammert, Marcel A.; Dietlein, Felix; Heuckmann, Johannes M.; Choidas, Axel; Boehm, Stefanie; Richters, Andre; Basu, Debjit; Tischler, Verena; Lorenz, Carina; Habenberger, Peter; Fang, Zhizhou; Ortiz-Cuaran, Sandra; Leenders, Frauke; Eickhoff, Jan; Koch, Uwe; Getlik, Matthaeus; Termathe, Martin; Sallouh, Muhammad; Greff, Zoltan; Varga, Zoltan; Balke-Want, Hyatt; French, Christopher A.; Peifer, Martin; Reinhardt, H. Christian; Orfi, Laszlo; Keri, Gyorgy; Ansen, Sascha; Heukamp, Lukas C.; Buettner, Reinhard; Rauh, Daniel; Klebl, Bert M.; Thomas, Roman K.; Sos, Martin L.
err分享
err收藏
Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue
errSCIENTIFIC REPORTS
IF3.9
err2017-03-08
err8
errOAAI
errOrfi, Z.; Waczek, F.; Baska, F.; Szabadkai, I.; Torka, R.; Hartmann, J.; Orfi, L.; Ullrich, A.
err分享
err收藏
Redox Control of the Critical Immune Regulatory Enzyme Indoleamine 2,3-Dioxygenase by NADPH Oxidase 2-Derived Reactive Oxygen Species in Human Monocytes
errFREE RADICAL BIOLOGY AND MEDICINE
IF8.2
err2016-11-01
err0
PREAI
errYeung, Amanda W. S.; Lim, Yean J.; Hastad, Maria; Dang, Lei; Orfi, Laszlo; Szabadkai, Istvan; Keri, Gyorgy; Terentis, Andrew C.; King, Nicholas J. C.; Witting, Paul K.; Thomas, Shane R.
err分享
err收藏
Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle
errLIFE SCIENCES
IF5.1
err2016-10-01
err10
errOAAI
errCoucha, Maha; Abdelsaid, Mohammed; Li, Weiguo; Johnson, Maribeth H.; Orfi, Laszlo; El-Remessy, Azza B.; Fagan, Susan C.; Ergul, Adviye
err分享
err收藏

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