未登录Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier利用新生Fc受体(FcRn)增强抗体跨血脑屏障的转运
Lafrance-Vanasse, Julien; Sadekar, Shraddha S.; Yang, Yanli; Yadav, Daniela Bumbaca; Meilandt, William J.; Wetzel-Smith, Monica K.; Cai, Hao; Crowell, Susan R.; Nguyen, Van; Lee, Vivian; Chih, Ben; Kwong, Mandy; Chan, Pamela; Santagostino, Sara; Lee, Donna; Chung, Shan; Lazar, Greg A.; Ernst, James A.; Atwal, Jasvinder K. .png)
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收藏Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and Pharmacodynamics of Efmarodocokin Alfa, a Variably Glycosylated Fusion ProteinTao, Xun; Sukumaran, Siddharth; Sperinde, Gizette; Liu, Chang; Beardsley, Michelle Irwin; Day, Peter; Kalo, Matt; Ayewoh, Ebehiremen; Cai, Hao; Wang, Yehong; Jun, Inyoung; Hirst, Kyle; Nguyen, Van; Chung, Shan; Lee, Donna; Lekkerkerker, Annemarie; Stefanich, Eric 分享 收藏 Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug developmentLee, M. Violet; Saad, Ola M.; Wong, Sylvia; LaMar, Jason; Kamen, Lynn; Ordonia, Ben; Melendez, Rachel; Hassanzadeh, Azadeh; Chung, Shan; Kaur, Surinder 分享 收藏 分享 收藏 Neutralizing Antibody Validation Testing and Reporting HarmonizationMyler, Heather; Pedras-Vasconcelos, Joao; Lester, Todd; Civoli, Francesca; Xu, Weifeng; Wu, Bonnie; Vainshtein, Inna; Luo, Linlin; Hassanein, Mohamed; Liu, Susana; Ramaswamy, Swarna Suba; Mora, Johanna; Pennucci, Jason; McCush, Fred; Lavelle, Amy; Jani, Darshana; Ambakhutwala, Angela; Baltrukonis, Daniel; Barker, Breann; Carmean, Rebecca; Chung, Shan; Dai, Sheng; DeWall, Stephen; Dholakiya, Sanjay L.; Dodge, Robert; Finco, Deborah; Yan, Haoheng; Hays, Amanda; Hu, Zheng; Inzano, Cynthia; Kamen, Lynn; Lai, Ching-Ha; Meyer, Erik; Nelson, Robert; Paudel, Amrit; Phillips, Kelli; Poupart, Marie-Eve; Qu, Qiang; Abhari, Mohsen Rajabi; Ryding, Janka; Sheldon, Curtis; Spriggs, Franklin; Warrino, Dominic; Wu, Yuling; Yang, Lin; Pasas-Farmer, Stephanie 分享 收藏 Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug DevelopmentGokemeijer, Jochem; Wen, Yi; Jawa, Vibha; Mitra-Kaushik, Shibani; Chung, Shan; Goggins, Alan; Kumar, Seema; Lamberth, Kasper; Liao, Karen; Lill, Jennie; Phung, Qui; Walsh, Robin; Roberts, Brian J. J.; Swanson, Michael; Singh, Inderpal; Tourdot, Sophie; Kroenke, Mark A. A.; Rup, Bonita; Goletz, Theresa J. J.; Gupta, Swati; Malherbe, Laurent; Pattijn, Sofie 分享 收藏 Correction to: Preclinical development of ZED8, an 89Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapyOgasawara, Annie; Kiefer, James R.; Gill, Herman; Chiang, Eugene; Sriraman, Shravan; Ferl, Gregory Z.; Ziai, James; Bohorquez, Sandra Sanabria; Guelman, Sebastian; Wang, Xiangdan; Yang, Jihong; Phan, Minh Michael; Nguyen, Van; Chung, Shan; Yu, Christine; Tinianow, Jeff; Waaijer, Stijn Jan Hein; De Crespigny, Alex; Marik, Jan; Boswell, C. Andrew; Zabka, Tanja; Staflin, Karin; Williams, Simon-Peter 分享 收藏 Preclinical development of ZED8, an 89Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapyOgasawara, Annie; Kiefer, James R.; Gill, Herman; Chiang, Eugene; Sriraman, Shravan; Ferl, Gregory Z.; Ziai, James; Bohorquez, Sandra Sanabria; Guelman, Sebastian; Wang, Xiangdan; Yang, Jihong; Phan, Minh Michael; Van Nguyen; Chung, Shan; Yu, Christine; Tinianow, Jeff; Waaijer, Stijn Jan Hein; De Crespigny, Alex; Marik, Jan; Boswell, C. Andrew; Zabka, Tanja; Staflin, Karin; Williams, Simon-Peter 分享 收藏 An integrated approach for characterizing immunogenic responses toward a bispecific antibodyCohen, Sivan; Chung, Shan; Spiess, Christoph; Lundin, Victor; Stefanich, Eric; Laing, Steven T.; Clark, Vanessa; Brumm, Jochen; Zhou, Ying; Huang, Catherine; Guerrero, Joyce; Myneni, Srividya; Yadav, Rajbharan; Siradze, Ketevan; Peng, Kun 分享 收藏 分享 收藏 Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotinLi, Dongwei; Lee, Donna; Dere, Randall C.; Zheng, Bing; Yu, Shang-Fan; Fuh, Franklin K.; Kozak, Katherine R.; Chung, Shan; Yadav, Daniela Bumbaca; Nazzal, Denise; Danilenko, Dimitry; Go, Mary Ann T.; Williams, Marna; Polson, Andrew G.; Poon, Kirsten Achilles; Prabhu, Saileta 分享 收藏 An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humansChung, Shan; Van Nguyen; Lin, Yuwen Linda; Lafrance-Vanasse, Julien; Scales, Suzie J.; Lin, Kevin; Deng, Rong; Williams, Kathi; Sperinde, Gizette; Li, Juan Jenny; Zheng, Kai; Sukumaran, Siddharth; Tesar, Devin; Ernst, James A.; Fischer, Saloumeh; Lazar, Greg A.; Prabhu, Saileta; Song, An 分享 收藏 Anti-CD22 and anti-CD79b antibody-drug conjugates preferentially target proliferating B cellsFuh, Franklin K.; Looney, Caroline; Li, Dongwei; Poon, Kirstena; Dere, Randall C.; Danilenko, Dimitry M.; McBride, Jacqueline; Reed, Chae; Chung, Shan; Zheng, Bing; Mathews, William Rodney; Polson, Andrew; Prabhu, Saileta; Williams, Marna 分享 收藏 Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice维持抗体稳定性并降低小鼠毒性的效应子减毒取代Lo, Megan; Kim, Hok Seon; Tong, Raymond K.; Bainbridge, Travis W.; Vernes, Jean-Michel; Zhang, Yin; Lin, Yuwen Linda; Chung, Shan; Dennis, Mark S.; Zuchero, Y. Joy Yu; Watts, Ryan J.; Couch, Jessica A.; Meng, Y. Gloria; Atwal, Jasvinder K.; Brezski, Randall J.; Spiess, Christoph; Ernst, James A. 分享 收藏 分享 收藏 Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycansYu, Marcella; Brown, Darren; Reed, Chae; Chung, Shan; Lutman, Jeff; Stefanich, Eric; Wong, Anne; Stephan, Jean-Philippe; Bayer, Robert 分享 收藏 分享 收藏 Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcy receptor binding and antibody-dependent cell-mediated cytotoxicity activities人源化抗体对Fcy受体结合和抗体依赖性细胞介导的细胞毒性活性的岩藻糖减少作用的定量评估Chung, Shan; Quarmby, Valerie; Gao, Xiaoying; Ying, Yong; Lin, Linda; Reed, Chae; Fong, Chris; Lau, Wendy; Qiu, Zhihua J.; Shen, Amy; Vanderlaan, Martin; Song, An 分享 收藏 分享 收藏 Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1Yan, Boxu; Boyd, Daniel; Kaschak, Timothy; Tsukuda, Joni; Shen, Amy; Lin, Yuwen; Chung, Shan; Gupta, Priyanka; Kamath, Amrita; Wong, Anne; Vernes, Jean-Michel; Meng, Gloria Y.; Totpal, Klara; Schaefer, Gabriele; Jiang, Guoying; Nogal, Bartek; Emery, Craig; Vanderlaan, Martin; Carter, Paul; Harris, Reed; Amanullah, Ashraf 分享 收藏 
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