Yilai Shu - Publications, H-index & Citations

舒易来* (Yilai Shu)

fudan university

38H指数

160论文数

6.5K被引数

收录论文 79

发表时间

Efficacy and Safety of Intracochlear Corticosteroid Delivery as Salvage Therapy for Complete Sudden Sensorineural Hearing Loss 经耳蜗糖皮质激素递送作为完全性突发性听力损失挽救治疗的有效性与安全性

Hearing Research

IF2.5

2026-09-19

PREAI

Wei Li; Andi Zhang; Yanqing Fang; Yi Wang; Dongmei Tang; Ying Ma; Xintai Fan; Yibo Huang; Jianghong Xu; Hui Zhao; Jing Wang; Chunfu Dai; Wuqing Wang; Yilai Shu; Huawei Li

Author Correction: A base editor for the long-term restoration of auditory function in mice with recessive profound deafness 作者更正：一种用于恢复隐性重度耳聋小鼠长期听觉功能的基础编辑器

Nature Biomedical Engineering

IF26.6

2026-09-07

PREAI

Chong Cui; Shengyi Wang; Daqi Wang; Jingjing Zhao; Bowei Huang; Biyun Zhu; Yuxin Chen; Honghai Tang; Yu Han; Cheng Ye; Dan Mu; Chengdong Zhang; Yuan Yang; Yihan Bao; Jun Lv; Shuang Han; Geng-Lin Li; Huawei Li; Yilai Shu

Schisantherin B mitigates cisplatin-induced ototoxicity by modulating the CNPY2-PERK/CHOP signaling axis Schisantherin B通过调节CNPY2-PERK/CHOP信号轴减轻顺铂诱导的耳毒性

Biochemical Pharmacology

IF5.6

2026-09-06

PREAI

Ziwen Gao; Hui Huang; Ping Yang; Weida Zhang; Shaowei Hu; Lei Han; Hu Zhou; Yilai Shu

Age outweighs route for AAV-PHP.eB transgene distribution via inner ear delivery 年龄比途径更重要：通过内耳给药途径AAV-PHP.eB转基因分布

Drug Delivery and Translational Research

IF5.5

2026-07-22

PREAI

Shuang Han; Yi Zhou; Honghai Tang; Shao Wei Hu; Guannan Geng; Ziting Chen; Sen Zhang; Hongbo Tang; Huawei Li; QingShan Jiang; Yilai Shu

Re-administration of AAV-mediated gene therapy for OTOF-related deafness: a single-arm trial AAV介导的基因治疗对OTOF相关耳聋的再管理: 单臂试验

Nature Medicine

IF50

2026-06-26

PREAI

Xintai Fan; Longlong Zhang; Ziwen Gao; Lei Han; Ping Yang; Daqi Wang; Hongbing Yu; Qi Cao; Luoying Jiang; Xiaoyun Chen; Xin Zhang; Xiaoting Cheng; Liheng Chen; Jiake Zhong; Jun Lv; Wei Wang; Liling Dai; Ziyi Zhou; Linjie Shi; Yuxin Chen; Biyun Zhu; Shaowei Hu; Honghai Tang; Zheng-Yi Chen; Wuqing Wang; Bing Chen; Huawei Li; Yilai Shu

Schizantherin B alleviates cisplatin-induced ototoxicity and does not interfere cisplatin-based chemotherapy in a breast cancer model Schizantherin B缓解顺铂诱导的耳毒性，且在乳腺癌模型中不干扰顺铂为基础的化疗

Archives of Toxicology

IF6.9

2026-05-13

PREAI

Zirui Zhao; Lei Han; Zhijiao Xu; Benyu Nan; Honghai Tang; Dingding Dong; Zhen Zen; Ziwen Gao; Cheng Ye; Xinsheng Huang; Jianning Zhang; Geng-Lin Li; Yilai Shu

Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years OTOF相关耳聋的多中心基因治疗随访2.5年

Nature

IF48.5

2026-04-22

PREAI

Luoying Jiang; Xiaoting Cheng; Jun Lv; Yuxin Chen; Xiaoyun Chen; Rongqun Zhai; Liqin Zhang; Lei Han; Yiling Zhang; Juhong Zhang; Di Deng; Zhicheng Huang; Qi Cao; Xin Zhang; Daqi Wang; Yizhe Wang; Liheng Chen; Sha Yu; Luo Guo; Bowen Zhang; Hui Wang; Yi Zhou; Liling Dai; Wei Wang; Longlong Zhang; Yanbo Yin; Guiqing Cheng; Ziyi Zhou; Wuqing Wang; Bing Chen; Wei Lu; Hongqun Jiang; Zhiqiang Gao; Dazhi Shi; Yuanping Xiong; Yu Zhao; Wei Yuan; Qin Wang; Guodong Feng; Huawei Li; Zheng-Yi Chen; Yilai Shu

Genetic analysis of patients with low-frequency non-syndromic hearing loss 低频非综合征性听力损失患者的遗传分析

MOLECULAR GENETICS AND GENOMICS

IF2.1

2025-12-01

PREAI

Yu, Sha; Li, Weitao; Lin, Xinhao; Chen, Liheng; Chen, Wenxia; Guo, Luo; Shu, Yilai

International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials 遗传性听力损失基因治疗国际专家共识：基于临床试验

Med

IF11.8

2025-10-23

OAAI

Xintai Fan; Ziwen Gao; Jiake Zhong; Yuxin Chen; Xiaoyun Chen; Lukas D. Landegger; Tobias Moser; Fan-Gang Zeng; Yu Sun; Xin Jin; Robert Nash; Wade W. Chien; Dan Jiang; John H. Greinwald; Manohar Bance; Manuel Manrique Rodríguez; Sang-Yeon Lee; Guodong Feng; Haidi Yang; Chen-Chi Wu; Lei Xu; Wei Yuan; Yong Feng; Yu Zhao; Barbara Vona; Nicola Strenzke; Dirk Beutner; Nikul Amin; James Arwyn-Jones; Deepak Chandrasekeharan; Dazhi Shi; Di Zhang; Jianming Yang; Jieyu Qi; Qin Wang; Yanbo Yin; Yen-Fu Cheng; Yong Tao; Yongfu Yu; Daqi Wang; Luoying Jiang; Luo Guo; Liheng Chen; Xiaoting Cheng; Chong Cui; Jun Lv; Shuang Han; Wuqing Wang; Yongxin Li; Xia Gao; Xue Zhong Liu; Dingjun Zha; Haibo Shi; Bing Chen; Qiuju Wang; Huijun Yuan; Shiming Yang; Shankai Yin; Hao Wu; Zhengmin Wang; Huawei Li; Jay T. Rubinstein; Lawrence R. Lustig; Renjie Chai; Zheng-Yi Chen; Yilai Shu

Unraveling the Genetic Basis of post-infancy diagnosed sensorineural hearing loss using whole exome sequencing 利用全外显子组测序解析婴儿期后诊断的感音神经性听力损失的遗传基础

Hearing Research

IF2.5

2025-10-16

PREAI

Weitao Li; Sha Yu; Biyun Zhu; Liheng Chen; Huawei Li; Luo Guo; Yilai Shu; Bing Chen

Single-dose genome editing therapy rescues auditory and vestibular functions in adult mice with DFNA41 deafness 单剂量基因组编辑疗法可恢复DFNA41耳聋成年小鼠的听力和前庭功能

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-10-15

PREAI

Wei, Wei; Zhu, Wenliang; Silver, Stewart; Armstrong, Ariel M.; Robbins, Fletcher S.; Rameshbabu, Arun Prabhu; Walz, Katherina; Quan, Yizhou; Du, Wan; Kim, Yehree; Indzhykulian, Artur A.; Shu, Yilai; Liu, Xue-Zhong; Chen, Zheng-Yi

Unlocking mRNA-driven CRISPR/Cas9 gene therapy via optimizing mRNA and the delivery vectors 通过优化mRNA和递送载体解锁mRNA驱动的CRISPR/Cas9基因疗法

Molecular Therapy Nucleic Acids

IF6.1

2025-10-11

OAAI

Shengyi Wang; Xiaoyu Xu; Tapani Viitala; Yilai Shu; Hongbo Zhang

Comparative analysis of RNA versus protein splicing in dual AAV-mediated gene therapy in a mouse model of DFNB9 deafness DFNB9型耳聋小鼠模型中AAV介导的双基因疗法中RNA与蛋白质剪接的对比分析

Molecular Therapy

IF12

2025-10-06

PREAI

Mengzhao Xun; Xintai Fan; Hui Wang; Jingjing Zhao; Gongrui Tang; Weida Zhang; Shaowei Hu; Longlong Zhang; Daqi Wang; Yuxin Chen; Jianping Liu; Honghai Tang; Geng-Lin Li; Bing Chen; Yilai Shu

Clinical gene therapy restores hearing: a paradigm shift 临床基因治疗恢复听力：一种范式转变

Trends in Molecular Medicine

IF13.8

2025-09-03

PREAI

Shuang Han; Ziting Chen; Daqi Wang; Luoying Jiang; Xintai Fan; Jiake Zhong; Chong Cui; Yuxin Chen; Jun lv; Jiajia Zhang; Yu Zhao; Dazhi Shi; Wei Lu; Suijun Chen; Hongqun Jiang; Wei Yuan; Qin Wang; GuoDong Feng; Xuezhong Liu; Huijun Yuan; Fan-Gang Zeng; Huawei Li; Zheng-Yi Chen; Yilai Shu

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy 治疗听力损失：从人工耳蜗植入到基因治疗

ADVANCED SCIENCE

IF14.1

2025-09-01

OAAI

Zeng, Fan-Gang; Qi, Jieyu; Wu, Chen-Chi; Shu, Yilai; Chai, Renjie

Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates AAV1-hOTOF在小鼠和非人灵长类动物中的疗效和安全性预临床评估

Molecular Therapy Methods & Clinical Development

IF4.7

2025-08-22

OAAI

Longlong Zhang; Hui Wang; Mengzhao Xun; Honghai Tang; Jinghan Wang; Jun Lv; Biyun Zhu; Yuxin Chen; Daqi Wang; Shaowei Hu; Ziwen Gao; Jianping Liu; Zheng-Yi Chen; Bing Chen; Huawei Li; Yilai Shu

Hearing restoration by gene replacement therapy for a multisite-expressed gene in a mouse model of human DFNB111 deafness 通过基因替代疗法恢复多部位表达基因在小鼠模型中的人DFNB111耳聋

american journal of human genetics

IF0

2025-08-20

PREAI

Luoying Jiang; Shao Wei Hu; Zijing Wang; Yi Zhou; Honghai Tang; Yuxin Chen; Daqi Wang; Xintai Fan; Lei Han; Huawei Li; Dazhi Shi; Yingzi He; Yilai Shu

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation PAM-flexible腺嘌呤碱基编辑技术挽救了携带东亚始祖突变的人源化MPZL2小鼠模型的听力损失

Nature Communications

IF15.7

2025-08-05

OAAI

Shao Wei Hu; Sohyang Jeong; Luoying Jiang; Hansol Koo; Zijing Wang; Won Hoon Choi; Biyun Zhu; Heeyoung Seok; Yi Zhou; Min Gu Kim; Dan Mu; Huixia Guo; Ziyi Zhou; Sung Ho Jung; Yingting Zhang; Ho Byung Chae; Liheng Chen; Sung-Yeon Lee; Luo Guo; Myung-Whan Suh; Yang Xiao; Moo Kyun Park; Honghai Tang; Jae-Jin Song; Xi Chen; Ai Chen; Jun Ho Lee; Sangsu Bae; Sang-Yeon Lee; Yilai Shu

Leonurine protects against cisplatin-induced ototoxicity through its anti-oxidation and anti-apoptosis properties Leonurine 通过其抗氧化和抗凋亡特性保护 against 顺铂引起的耳毒性。

Toxicology Letters

IF2.9

2025-07-01

PREAI

Zhen Zeng; Lei Han; Dingding Dong; Honghai Tang; Ziwen Gao; Shaowei Hu; Biyun Zhu; Sen Zhang; Yilai Shu; Yafeng Yu

Viral and non-viral vectors in gene therapy: current state and clinical perspectives 病毒和非病毒载体在基因治疗中的应用：现状与临床展望

eBioMedicine

IF10.8

2025-07-01

OAAI

Guannan Geng; Yixin Xu; Ziying Hu; Hui Wang; Xiaoyun Chen; Wei Yuan; Yilai Shu

研究方向