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J

James Spencer

University of Bristol

60H指数
322论文数
1.7W被引数
收录论文 112
发表时间
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Dynamical-nonequilibrium alanine scanning for identifying allosteric positions in proteins动力学非平衡丙氨酸扫描用于识别蛋白质中的别构位点
errBiophysical Journal
IF3.1
err2026-08-01
err0
PREAI
errBalega, Balazs; Beer, Michael; Pike, Dan T. S.; Spencer, James; Oliveira, A. Sofia F.; Mulholland, Adrian J.
err分享
err收藏
Mutasynthesis and Antibiotic Activity of Mupirocin Analogues通过突变合成法制备的莫匹罗星类似物的抗生菌活性
errChemBioChem
IF2.8
err2026-06-30
err0
errOAAI
errSarah M. Husain; Luoyi Wang; Li-Chen Han; James I. Bowen; Zhongshu Song; Felix de Courcy-Ireland; Ashley J. Winter; Thomas J. Simpson; Paul R. Race; James Spencer; Matthew P. Crump; Christine L. Willis
err分享
err收藏
Hydrogen-Bonding Changes Cause Differences in Imipenem Breakdown Activity in OXA-48 Variants氢键变化导致OXA-48变体中亚胺培南分解活性的差异
errJournal of Chemical Information and Modeling
IF5.3
err2026-04-22
err0
errOAAI
errDaojiong Wang; Adrian J. Mulholland; James Spencer; Marc W. van der Kamp
err分享
err收藏
All Roads Lead to Carbinolamine: QM/MM Study of Enzymatic C-N Bond Cleavage in Anaerobic Glycyl Radical Enzyme Choline Trimethylamine-Lyase (CutC)Hanzevacki, M.; Güven, J.J.; Hinchliffe, P.; Shaw, J.; Mey, A.S.J.S.; Fey, N.; Spencer, J.; Mulholland, A.J. 所有路径都指向卡宾醇胺：量子力学/分子力学（QM/MM）研究厌氧甘氨酸自由基酶胆碱三甲胺裂解酶（CutC）中的酶促C-N键断裂。J. Phys. Chem. B 2025, 129, 9322–9332. [Google Scholar] [CrossRef]
errJOURNAL OF PHYSICAL CHEMISTRY B
IF2.9
err2025-09-01
err0
errOAAI
errHanzevacki, Marko; Guven, J. Jasmin; Hinchliffe, Philip; Shaw, John; Mey, Antonia S. J. S.; Fey, Natalie; Spencer, James; Mulholland, Adrian J.
err分享
err收藏
Mechanistic basis for inhibition of the extended-spectrum β-lactamase GES-1 by enmetazobactam and tazobactam广谱β-内酰胺酶GES-1被恩美他唑巴坦和他唑巴坦抑制的机制基础
errFEBS LETTERS
IF3
err2025-09-01
err0
errOAAI
errBeer, Michael; Hinchliffe, Philip; Hanzevacki, Marko; Bethel, Christopher R.; Tooke, Catherine L.; van der Kamp, Marc W.; Papp-Wallace, Krisztina M.; Bonomo, Robert A.; Shapiro, Stuart; Mulholland, Adrian J.; Spencer, James
err分享
err收藏
Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases静电相互作用影响diaza bicyclooctane抑制剂的活性对OXA-48-like β-内酰胺酶的效力
errRSC Med. Chem.
IF3.6
err2025-08-09
err0
errOAAI
errJoseph Francis Hoff; Kirsty Elizabeth Goudar; Karina Calvopiña; Michael Beer; Philip Hinchliffe; John Shaw; Catherine Louise Tooke; Yuiko Takebayashi; Andrew Cadzow; Nicholas Harmer; Adrian John Mulholland; Christopher J Schofield; James Spencer
err分享
err收藏
Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment在膜环境中通过分子动力学模拟研究的MCR-1多黏菌素耐药决定因子的动态行为与底物相互作用
errJournal of Chemical Information and Modeling
IF5.3
err2025-07-22
err0
PREAI
errEmily Lythell; Jack Badley; Reynier Suardíaz; Catherine R. Gurr; Catherine L. Tooke; Philip Hinchliffe; A. Sofia F. Oliveira; Marc W. Van der Kamp; James Spencer; Adrian J. Mulholland
err分享
err收藏
Repurposing of compound libraries yields new inhibitors of NDM-1 metallo-β-lactamase with diverse zinc-binding moieties化合物库的重新利用产生了针对NDM-1金属β-内酰胺酶的新型抑制剂，其锌结合基团具有多样性。
errEuropean Journal of Medicinal Chemistry Reports
IF4.1
err2025-06-19
err0
errOAAI
errVid Kavaš; Philip Hinchliffe; Maša Zorman; Alen Krajnc; Matic Proj; Majda Golob; Martina Hrast Rambaher; James Spencer; Stanislav Gobec
err分享
err收藏
Hybrid virtual screening identifies dipyrazole carboxamide derivatives as novel direct InhA inhibitors with antitubercular activity杂交虚拟筛选识别出二吡唑羧酰胺衍生物作为具有抗结核活性的新型直接 InhA 抑制剂
errbiochimica et biophysica acta general subjects
IF0
err2025-05-26
err0
PREAI
errAuradee Punkvang; Bongkochawan Pakamwong; Naruedon Phusi; Paptawan Thongdee; Kampanart Chayajarus; Jidapa Sangswan; Kanjana Pangjit; Khomson Suttisintong; Jiraporn Leanpolchareanchai; Poonpilas Hongmanee; Pitak Santanirand; James Spencer; Adrian J. Mulholland; Sanya Sureram; Prasat Kittakoop; Pornpan Pungpo
err分享
err收藏
C2-Linked Arabinose-Functionalized Polystyrene Microbeads Selectively Target Staphylococcus aureusC2-Linked阿拉伯糖功能化聚苯乙烯微珠选择性靶向金黄色葡萄球菌
errJACS AU
IF8.7
err2024-11-08
err0
errOAAI
errWalke, Gulab; Santi, Cristina; Haydon, Calum; Joshi, Pooja; Takebayashi, Yuiko; Rama, Sylvain; Dorh, Josephine; Hotha, Srinivas; Spencer, James; Galan, M. Carmen
err分享
err收藏
Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products (Vol 300, 107819, 2024)
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-10-01
err1
errOAAI
errHinchliffe, Philip; Calvopina, Karina; Rabe, Patrick; Mojica, Maria F.; Schofield, Christopher J.; Dmitrienko, Gary I.; Bonomo, Robert A.; Vila, Alejandro J.; Spencer, James
err分享
err收藏
Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit Validation by Biological Assays
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-07-12
err5
errOAAI
errPakamwong, Bongkochawan; Thongdee, Paptawan; Kamsri, Bundit; Phusi, Naruedon; Taveepanich, Somjintana; Chayajarus, Kampanart; Kamsri, Pharit; Punkvang, Auradee; Hannongbua, Supa; Sangswan, Jidapa; Suttisintong, Khomson; Sureram, Sanya; Kittakoop, Prasat; Hongmanee, Poonpilas; Santanirand, Pitak; Leanpolchareanchai, Jiraporn; Spencer, James; Mulholland, Adrian J.; Pungpo, Pornpan
err分享
err收藏
Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics
errPLOS PATHOGENS
IF4.9
err2024-06-06
err0
errOAAI
errDulyayangkul, Punyawee; Beavis, Thomas; Lee, Winnie W. Y.; Ardagh, Robbie; Edwards, Frances; Hamilton, Fergus; Head, Ian; Heesom, Kate J.; Mounsey, Oliver; Murarik, Marek; Pinweha, Peechanika; Reding, Carlos; Satapoomin, Naphat; Shaw, John M.; Takebayashi, Yuiko; Tooke, Catherine L.; Spencer, James; Williams, Philip B.; Avison, Matthew B.
err分享
err收藏
Electric Fields Are a Key Determinant of Carbapenemase Activity in Class A β-Lactamases
errACS CATALYSIS
IF13.1
err2024-04-23
err4
errOAAI
errJabeen, Hira; Beer, Michael; Spencer, James; van der Kamp, Marc W.; Bunzel, H. Adrian; Mulholland, Adrian J.
err分享
err收藏
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-02-19
err2
PREAI
errVillamil, Valentina; Rossi, Maria-Agustina; Mojica, Maria F.; Hinchliffe, Philip; Martinez, Veronica; Castillo, Valerie; Saiz, Cecilia; Banchio, Claudia; Macias, Mario A.; Spencer, James; Bonomo, Robert A.; Vila, Alejandro; Moreno, Diego M.; Mahler, Graciela
err分享
err收藏
Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme
errCHEMICAL SCIENCE
IF7.4
err2024-01-01
err1
errOAAI
errBeer, Michael; Oliveira, Ana Sofia F.; Tooke, Catherine L.; Hinchliffe, Philip; Tsz Yan Li, Angie; Balega, Balazs; Spencer, James; Mulholland, Adrian J.
err分享
err收藏
Ab initio quantum chemistry with neural-network wavefunctions
errNATURE REVIEWS CHEMISTRY
IF51.7
err2023-08-09
err33
errOAAI
errHermann, Jan; Spencer, James; Choo, Kenny; Mezzacapo, Antonio; Foulkes, W. M. C.; Pfau, David; Carleo, Giuseppe; Noe, Frank
err分享
err收藏
Enhancement by pyrazolones of colistin efficacy against mcr-1-expressing E. coli: an in silico and in vitro investigation
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2023-07-24
err0
PREAI
errHanpaibool, Chonnikan; Ounjai, Puey; Yotphan, Sirilata; Mulholland, Adrian J.; Spencer, James; Ngamwongsatit, Natharin; Rungrotmongkol, Thanyada
err分享
err收藏
Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-05-01
err6
errOAAI
errHinchliffe, Philip; Calvopina, Karina; Rabe, Patrick; Mojica, Maria F.; Schofiled, Christopher J.; Dmitrienko, Gary I.; Bonomo, Robert A.; Vila, Alejandro J.; Spencer, James
err分享
err收藏
Bioisosteric Design Identifies Inhibitors of Mycobacterium tuberculosis DNA Gyrase ATPase Activity
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-04-19
err2
PREAI
errKamsri, Bundit; Pakamwong, Bongkochawan; Thongdee, Paptawan; Phusi, Naruedon; Kamsri, Pharit; Punkvang, Auradee; Ketrat, Sombat; Saparpakorn, Patchreenart; Hannongbua, Supa; Sangswan, Jidapa; Suttisintong, Khomson; Sureram, Sanya; Kittakoop, Prasat; Hongmanee, Poonpilas; Santanirand, Pitak; Leanpolchareanchai, Jiraporn; Goudar, Kirsty E.; Spencer, James; Mulholland, Adrian J.; Pungpo, Pornpan
err分享
err收藏

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