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K

Kathryn E. Wellen

university of pennsylvania perelman school of medicine

52H指数
175论文数
2.3W被引数
收录论文 80
发表时间
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Acetyl-CoA–dependent processes are preferentially supported by local metabolite synthesis乙酰辅酶A依赖性过程优先由局部代谢物合成支持
errScience Advances
IF12.5
err2026-09-11
err0
errOAAI
errJulianna G. Supplee; Pedro Costa-Pinheiro; Karl Wessendorf-Rodriguez; Stephanie Stransky; Qihua Yang; Christina Demetriadou; Nivitha Murali; Joy Li; Jennifer L. Pennise; Mariola M. Marcinkiewicz; Simone Sidoli; Nathaniel W. Snyder; Christian M. Metallo; Ronen Marmorstein; Kathryn E. Wellen
err分享
err收藏
A lysis-derived PMSF and orthovanadate oxidant defines a distinct cysteine-engagement profile来源于裂解的PMSF和偏钒酸盐氧化剂定义了一种独特的半胱氨酸参与谱图
errCell Chemical Biology
IF7.2
err2026-08-31
err0
PREAI
errBethany E. Schaffer; Jung Seung Nam; Ceci A. Cohen; Clementina Mesaros; Robert W. Myers; Leigh Baxt; Kathryn E. Wellen; Lewis C. Cantley; Noah Dephoure; Nathaniel W. Snyder; Iok In Christine Chio; John Blenis
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Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis作者更正：癌症相关成纤维细胞衍生的醋酸盐通过ACSS2–SP1–SAT1轴改变多胺代谢促进胰腺癌发展
errNature Cell Biology
IF19.1
err2026-08-04
err0
errOAAI
errDivya Murthy; Kuldeep S. Attri; Surendra K. Shukla; Ravi Thakur; Nina V. Chaika; Chunbo He; Dezhen Wang; Kanupriya Jha; Aneesha Dasgupta; Ryan J. King; Scott E. Mulder; Joshua Souchek; Teklab Gebregiworgis; Vikant Rai; Rohit Patel; Tuo Hu; Sandeep Rana; Sai Sundeep Kollala; Camila Pacheco; Paul M. Grandgenett; Fang Yu; Vikas Kumar; Audrey J. Lazenby; Adrian R. Black; Susanna Ulahannan; Ajay Jain; Barish H. Edil; David L. Klinkebiel; Robert Powers; Amarnath Natarajan; Michael A. Hollingsworth; Kamiya Mehla; Quan Ly; Sarika Chaudhary; Rosa F. Hwang; Kathryn E. Wellen; Pankaj K. Singh
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Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas线粒体ACSS1将乙酸代谢与嘧啶生物合成联系起来，在营养应激的B细胞淋巴瘤中。
errCancer Letters
IF10.1
err2026-04-07
err0
errOAAI
errJohnvesly Basappa; Aaron R. Goldman; Cosimo Lobello; Shengchun Wang; David Rushmore; Olga Melnikov; Neil V. Sen; Vinay S. Mallikarjuna; Priyanka Jain; Masoud Edalati; David S. Nelson; Kathy Q. Cai; Pin Lu; Reza Nejati; Hossein Borghaei; Pradeep K. Gupta; Kavindra Nath; Kathryn E. Wellen; Mariusz A. Wasik
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Metabolism modulates stress and neoplasia代谢调节应激和肿瘤发生
errNature Metabolism
IF20.8
err2026-04-01
err0
PREAI
errMichael C. Noji; Kathryn E. Wellen
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ACLY-Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation-Associated Fibrosis in Chronic Kidney Disease乙酰辅酶A羧化酶样蛋白1（ACLY）驱动的代谢重编程促进慢性肾脏病中组蛋白乙酰化和炎症相关纤维化
errAdvanced Science
IF14.1
err2026-04-01
err0
errOAAI
errDu, Chunxiu; Mukhi, Dhanunjay; Li, Lingzhi; Li, Chenyu; Pan, Siyu; Dumoulin, Bernhard; Ha, Eunji; Kolligundla, Lakshmi P.; Hou, Yanjuan; Levinsohn, Jonathan; Kang, Chaelin; Klotzer, Konstantin Adrian; Wu, Junnan; Mohandes, Samer; Wellen, Kathryn E.; Susztak, Katalin
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Molecular targets of bempedoic acid and related decoy fatty acids贝派地酸及其相关诱饵脂肪酸的分子靶点
errtrends in endocrinology and metabolism
IF0
err2025-05-08
err0
PREAI
errJulianna G. Supplee; Ronen Marmorstein; Kathryn E. Wellen
err分享
err收藏
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis皮肤中的乙酰辅酶A合成是系统性脂质稳态的关键决定因素。
errCELL REPORTS
IF6.9
err2025-02-01
err1
errOAAI
errNguyen, Phuong T. T.; Shiue, Mia; Kuprasertkul, Nina; Costa-Pinheiro, Pedro; Izzo, Luke T.; Pinheiro, Laura V.; Affronti, Hayley A.; Gugiu, Gabriel; Ghaisas, Shivani; Liu, Joyce Y.; Harris, Jordan C.; Bradley, Charles W.; Seykora, John T.; Yang, Xiaolu; Kambayashi, Taku; Mesaros, Clementina; Capell, Brian C.; Wellen, Kathryn E.
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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress
errNATURE METABOLISM
IF20.8
err2024-10-14
err0
PREAI
errKorobkina, Ekaterina D.; Calejman, Camila Martinez; Haley, John A.; Kelly, Miranda E.; Li, Huawei; Gaughan, Maria; Chen, Qingbo; Pepper, Hannah L.; Ahmad, Hafsah; Boucher, Alexander; Fluharty, Shelagh M.; Lin, Te-Yueh; Lotun, Anoushka; Peura, Jessica; Trefely, Sophie; Green, Courtney R.; Vo, Paula; Semenkovich, Clay F.; Pitarresi, Jason R.; Spinelli, Jessica B.; Aydemir, Ozkan; Metallo, Christian M.; Lynes, Matthew D.; Jang, Cholsoon; Snyder, Nathaniel W.; Wellen, Kathryn E.; Guertin, David A.
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Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program核ATP-柠檬酸裂解酶调节染色质依赖性激活和肌成纤维细胞基因程序的维持
errcardiovascular research
IF10.8
err2024-07-05
err2
errOAAI
errLazaropoulos, Michael P.; Gibb, Andrew A.; Chapski, Douglas J.; Nair, Abheya A.; Reiter, Allison N.; Roy, Rajika; Eaton, Deborah M.; Bedi, Kenneth C.; Margulies, Kenneth B.; Wellen, Kathryn E.; Estaras, Conchi; Vondriska, Thomas M.; Elrod, John W.
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ACLY alternative splicing correlates with cancer phenotypes
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-07-01
err2
errOAAI
errSupplee, Julianna G.; Affronti, Hayley C.; Duan, Richard; Brooks, Rebekah C.; Stine, Zachary E.; Nguyen, Phuong T. T.; V. Pinheiro, Laura; Noji, Michael C.; Drummond, Jack M.; Huang, Kevin; Schultz, Kollin; V. Dang, Chi; Marmorstein, Ronen; Wellen, Kathryn E.
err分享
err收藏
Metabolic Signaling in Cancer癌症中的代谢信号传导
errCOLD SPRING HARBOR PERSPECTIVES IN MEDICINE
IF10.1
err2024-06-10
err0
PREAI
errPinheiro, Laura V.; Costa-Pinheiro, Pedro; Wellen, Kathryn E.
err分享
err收藏
N-glycosylation by Mgat5 imposes a targetable constraint on immunemediated tumor clearance
errJCI INSIGHT
IF6.1
err2024-05-23
err1
errOAAI
errHollander, Erin E.; Flock, Rosemary E.; Mcdevitt, Jayne C.; Vostrejs, William P.; Campbell, Sydney L.; Orlen, Margo I.; Kemp, Samantha B.; Kahn, Benjamin M.; Wellen, Kathryn E.; Kim, Il-Kyu; Stanger, Ben Z.
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err收藏
Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis (vol 26, pg 613, 2024)
errNATURE CELL BIOLOGY
IF19.1
err2024-04-19
err1
errOAAI
errMurthy, Divya; Attri, Kuldeep S.; Shukla, Surendra K.; Thakur, Ravi; Chaika, Nina V.; He, Chunbo; Wang, Dezhen; Jha, Kanupriya; Dasgupta, Aneesha; King, Ryan J.; Mulder, Scott E.; Souchek, Joshua; Gebregiworgis, Teklab; Rai, Vikant; Patel, Rohit; Hu, Tuo; Rana, Sandeep; Kollala, Sai Sundeep; Pacheco, Camila; Grandgenett, Paul M.; Yu, Fang; Kumar, Vikas; Lazenby, Audrey J.; Black, Adrian R.; Ulhannan, Susanna; Jain, Ajay; Edil, Barish H.; Klinkebiel, David L.; Powers, Robert; Natarajan, Amarnath; Hollingsworth, Michael A.; Mehla, Kamiya; Ly, Quan; Chaudhary, Sarika; Hwang, Rosa F.; Wellen, Kathryn E.; Singh, Pankaj K.
err分享
err收藏
Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis
errNATURE CELL BIOLOGY
IF19.1
err2024-03-01
err11
errOAAI
errMurthy, Divya; Attri, Kuldeep S.; Shukla, Surendra K.; Thakur, Ravi; Chaika, Nina V.; He, Chunbo; Wang, Dezhen; Jha, Kanupriya; Dasgupta, Aneesha; King, Ryan J.; Mulder, Scott E.; Souchek, Joshua; Gebregiworgis, Teklab; Rai, Vikant; Patel, Rohit; Hu, Tuo; Rana, Sandeep; Kollala, Sai Sundeep; Pacheco, Camila; Grandgenett, Paul M.; Yu, Fang; Kumar, Vikas; Lazenby, Audrey J.; Black, Adrian R.; Ulhannan, Susanna; Jain, Ajay; Edil, Barish H.; Klinkebiel, David L.; Powers, Robert; Natarajan, Amarnath; Hollingsworth, Michael A.; Mehla, Kamiya; Ly, Quan; Chaudhary, Sarika; Hwang, Rosa F.; Wellen, Kathryn E.; Singh, Pankaj K.
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ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2023-12-05
err11
errOAAI
errMukhi, Dhanunjay; Li, Lingzhi; Liu, Hongbo; Doke, Tomohito; Kolligundla, Lakshmi P.; Ha, Eunji; Kloetzer, Konstantin; Abedini, Amin; Mukherjee, Sarmistha; Wu, Junnan; Dhillon, Poonam; Hu, Hailong; Guan, Dongyin; Funai, Katsuhiko; Uehara, Kahealani; Titchenell, Paul M.; Baur, Joseph A.; Wellen, Kathryn E.; Susztak, Katalin
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err收藏
A subpopulation of lipogenic brown adipocytes drives thermogenic memory
errNATURE METABOLISM
IF20.8
err2023-10-02
err10
errOAAI
errLundgren, Patrick; Sharma, Prateek V.; Dohnalova, Lenka; Coleman, Kyle; Uhr, Giulia T.; Kircher, Susanna; Litichevskiy, Lev; Bahnsen, Klaas; Descamps, Helene C.; Demetriadou, Christina; Chan, Jacqueline; Chellappa, Karthikeyani; Cox, Timothy O.; Heyman, Yael; Pather, Sarshan R.; Shoffler, Clarissa; Petucci, Christopher; Shalem, Ophir; Raj, Arjun; Baur, Joseph A.; Snyder, Nathaniel W.; Wellen, Kathryn E.; Levy, Maayan; Seale, Patrick; Li, Mingyao; Thaiss, Christoph A.
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Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer乙酸盐通过增强T细胞效应子功能和增强乳腺癌的抗肿瘤免疫力而充当代谢免疫调节剂
errNATURE CANCER
IF28.5
err2023-09-18
err25
errOAAI
errMiller, Katelyn D.; O'Connor, Seamus; Pniewski, Katherine A.; Kannan, Toshitha; Acosta, Reyes; Mirji, Gauri; Papp, Sara; Hulse, Michael; Mukha, Dzmitry; Hlavaty, Sabina I.; Salcido, Kelsey N.; Bertolazzi, Fabrizio; Srikanth, Yellamelli V. V.; Zhao, Steven; Wellen, Kathryn E.; Shinde, Rahul S.; Claiborne, Daniel T.; Kossenkov, Andrew; Salvino, Joseph M.; Schug, Zachary T.
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Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-06-01
err9
errOAAI
errSoaita, Ioana; Megill, Emily; Kantner, Daniel; Chatoff, Adam; Cheong, Yuen Jian; Clarke, Philippa; Arany, Zoltan; Snyder, Nathaniel W.; Wellen, Kathryn E.; Trefely, Sophie
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err收藏
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis乙酰肉碱穿梭将线粒体代谢与组蛋白乙酰化和脂肪生成联系起来
errSCIENCE ADVANCES
IF12.5
err2023-05-05
err31
errOAAI
errIzzo, Luke T.; Trefely, Sophie; Demetriadou, Christina; Drummond, Jack M.; Mizukami, Takuya; Kuprasertkul, Nina; Farria, Aimee T.; Nguyen, Phuong T. T.; Murali, Nivitha; Reich, Lauren; Kantner, Daniel S.; Shaffer, Joshua; Affronti, Hayley; Carrer, Alessandro; Andrews, Andrew; Capell, Brian C.; Snyder, Nathaniel W.; Wellen, Kathryn E.
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研究方向

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合作学者
合作期刊
C
Craig B. Thompson
H 指数: 206 · 论文数: 767
N
Norbert Perrimon
H 指数: 154 · 论文数: 868
M
Michael P. Murphy
H 指数: 142 · 论文数: 780
C
Christine A. Iacobuzio–Donahue
H 指数: 135 · 论文数: 1.0K
D
Douglas C. Wallace
H 指数: 134 · 论文数: 606
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