未登录 Differential regulation of BAX and BAK apoptotic activity revealed by small molecules 通过小分子揭示BAX和BAK凋亡活性的差异性调控 Li, Kaiming; Yap, Yu Q.; Moujalled, Donia M.; Sumardy, Fransisca; Khakham, Yelena; Georgiou, Angela; Jahja, Michelle; Lew, Thomas E.; De Silva, Melanie; Luo, Meng-Xiao; Gong, Jia-nan; Yuan, Zheng; Birkinshaw, Richard W.; Czabotar, Peter E.; Lowes, Kym; Huang, David C. S.; Kile, Benjamin T.; Wei, Andrew H.; Dewson, Grant; van Delft, Mark F. 分享 收藏
Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis 高尔基体定位的环指蛋白121是MYCN驱动的神经母细胞瘤肿瘤发生所必需的 Cheung, Belamy B.; Mittra, Ritu; Murray, Jayne; Wang, Qian; Seneviratne, Janith A.; Raipuria, Mukesh; Wong, Iris Poh Ling; Restuccia, David; Gifford, Andrew; Salib, Alice; Sutton, Selina; Huang, Libby; Ferdowsi, Parisa Vahidi; Tsang, Joanna; Sekyere, Eric; Mayoh, Chelsea; Luo, Lin; Brown, Darren L.; Stow, Jennifer L.; Zhu, Shizhen; Young, Richard J.; Solomon, Benjamin J.; Chappaz, Stephane; Kile, Benjamin; Kueh, Andrew; Herold, Marco J.; Hilton, Douglas J.; Liu, Tao; Norris, Murray D.; Haber, Michelle; Carter, Daniel R.; Parker, Michael W.; Marshall, Glenn M. 分享 收藏
The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis 转录共阻遏物Runx1t1对于MYCN驱动的神经母细胞瘤肿瘤发生至关重要 Murray, Jayne E.; Valli, Emanuele; Milazzo, Giorgio; Mayoh, Chelsea; Gifford, Andrew J.; Fletcher, Jamie I.; Xue, Chengyuan; Jayatilleke, Nisitha; Salehzadeh, Firoozeh; Gamble, Laura D.; Rouaen, Jourdin R. C.; Carter, Daniel R.; Forgham, Helen; Sekyere, Eric O.; Keating, Joanna; Eden, Georgina; Allan, Sophie; Alfred, Stephanie; Kusuma, Frances K.; Clark, Ashleigh; Webber, Hannah; Russell, Amanda J.; de Weck, Antoine; Kile, Benjamin T.; Santulli, Martina; De Rosa, Piergiuseppe; Fleuren, Emmy D. G.; Gao, Weiman; Wilkinson-White, Lorna; Low, Jason K. K.; Mackay, Joel P.; Marshall, Glenn M.; Hilton, Douglas J.; Giorgi, Federico M.; Koster, Jan; Perini, Giovanni; Haber, Michelle; Norris, Murray D. 分享 收藏
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy 线粒体内膜的暴露触发凋亡线粒体吞噬 Saunders, Tahnee L.; Windley, Simon P.; Gervinskas, Gediminas; Balka, Katherine R.; Rowe, Caitlin; Lane, Rachael; Tailler, Maximilien; Nguyen, Thanh Ngoc; Ramm, Georg; Lazarou, Michael; De Nardo, Dominic; Kile, Benjamin T.; Mcarthur, Kate 分享 收藏
BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking BECLIN1通过其在内细胞运输中的功能对涉及自噬非依赖性机制的肠道稳态至关重要 Tran, Sharon; Juliani, Juliani; Harris, Tiffany J.; Evangelista, Marco; Ratcliffe, Julian; Ellis, Sarah L.; Baloyan, David; Reehorst, Camilla M.; Nightingale, Rebecca; Luk, Ian Y.; Jenkins, Laura J.; Ghilas, Sonia; Yakou, Marina H.; Inguanti, Chantelle; Johnson, Chad; Buchert, Michael; Lee, James C.; De Cruz, Peter; Duszyc, Kinga; Gleeson, Paul A.; Kile, Benjamin T.; Mielke, Lisa A.; Yap, Alpha S.; Mariadason, John M.; Douglas Fairlie, W.; Lee, Erinna F. 分享 收藏
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Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation 巨核细胞具有STING途径，可转移到血小板以增强激活 El-Mortada, Firas; Landelouci, Karima; Bertrand-Perron, Samuel; Aube, Felix-Antoine; Bidias, Amel; Poirier, Amelie; Jourdi, Georges; Welman, Melanie; Gantier, Michael P.; Hamilton, Justin R.; Kile, Benjamin; Lordkipanidze, Marie; Pepin, Genevieve 分享 收藏
Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3 YAP1和STAT3介导胃肿瘤微环境中细胞串扰的机制 Thilakasiri, Pathum; O'Keefe, Ryan N.; To, Sarah Q.; Chisanga, David; Eissmann, Moritz F.; Carli, Annalisa L. E.; Duscio, Belinda; Baloyan, David; Dmello, Rhynelle S.; Williams, David; Mariadason, John; Poh, Ashleigh R.; Pal, Bhupinder; Kile, Benjamin; Vissers, Joseph H. A.; Harvey, Kieran F.; Buchert, Michael; Shi, Wei; Ernst, Matthias; Chand, Ashwini L. 分享 收藏
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Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection TBK1/ikk ε 的药理抑制作用使SARS-CoV-2感染小鼠模型的免疫病理学变钝 Ullah, Tomalika R.; Johansen, Matt D.; Balka, Katherine R.; Ambrose, Rebecca L.; Gearing, Linden J.; Roest, James; Vivian, Julian P.; Sapkota, Sunil; Jayasekara, W. Samantha N.; Wenholz, Daniel S.; Aldilla, Vina R.; Zeng, Jun; Miemczyk, Stefan; Nguyen, Duc H.; Hansbro, Nicole G.; Venkatraman, Rajan; Kang, Jung Hee; Pang, Ee Shan; Thomas, Belinda J.; Alharbi, Arwaf S.; Rezwan, Refaya; O'Keeffe, Meredith; Donald, William A.; Ellyard, Julia I.; Wong, Wilson; Kumar, Naresh; Kile, Benjamin T.; Vinuesa, Carola G.; Kelly, Graham E.; Laczka, Olivier F.; Hansbro, Philip M.; De Nardo, Dominic; Gantier, Michael P. 分享 收藏
Termination of STING responses is mediated via ESCRT-dependent degradation STING反应的终止是通过ESCRT依赖性降解介导的 Balka, Katherine R.; Venkatraman, Rajan; Saunders, Tahnee L.; Shoppee, Angus; Pang, Ee Shan; Magill, Zoe; Homman-Ludiye, Jihane; Huang, Cheng; Lane, Rachael M.; York, Harrison M.; Tan, Peck; Schittenhelm, Ralf B.; Arumugam, Senthil; Kile, Benjamin T.; O'Keeffe, Meredith; De Nardo, Dominic 分享 收藏
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production 高倍性大细胞质巨核细胞是造血干细胞调节剂，对血小板产生至关重要 Heazlewood, Shen Y. Y.; Ahmad, Tanveer; Cao, Benjamin; Cao, Huimin; Domingues, Melanie; Sun, Xuan; Heazlewood, Chad K. K.; Li, Songhui; Williams, Brenda; Fulton, Madeline; White, Jacinta F. F.; Nebl, Tom; Nefzger, Christian M. M.; Polo, Jose M. M.; Kile, Benjamin T. T.; Kraus, Felix; Ryan, Michael T. T.; Sun, Yu B. B.; Choong, Peter F. M.; Ellis, Sarah L. L.; Anko, Minna-Liisa; Nilsson, Susan K. K. 分享 收藏
Agm1/Pgm-3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development Agm1/Pgm-3-mediated糖核苷酸合成对造血和发育至关重要 Greig, Kylle T.; Antonchuk, Jennifer; Metcalf, Donald; Morgan, Phillip O.; Krebs, Danielle L.; Zhang, Jian-Guo; Hacking, Douglas F.; Bode, Lars; Robb, Lorraine; Kranz, Christian; de Graaf, Carolyn; Bahlo, Melanie; Nicola, Nicos A.; Nutt, Stephen L.; Freeze, Hudson H.; Alexander, Warren S.; Hilton, Douglas J.; Kile, Benjamin T. 分享 收藏
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Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML 浆细胞样DCs的表观遗传激活驱动AML的IFNAR依赖性治疗分化 Salmon, Jessica M.; Todorovski, Izabela; Stanley, Kym L.; Bruedigam, Claudia; Kearney, Conor J.; Martelotto, Luciano G.; Rossello, Fernando; Semple, Timothy; Arnau, Gisela Mir; Zethoven, Magnus; Bots, Michael; Bjelosevic, Stefan; Cluse, Leonie A.; Fraser, Peter J.; Litalien, Veronique; Vidacs, Eva; McArthur, Kate; Matthews, Antony Y.; Gressier, Elise; de Weerd, Nicole A.; Lichte, Jens; Kelly, Madison J.; Hogg, Simon J.; Hertzog, Paul J.; Kats, Lev M.; Vervoort, Stephin J.; De Carvalho, Daniel D.; Scheu, Stefanie; Bedoui, Sammy; Kile, Benjamin T.; Lane, Steven W.; Perkins, Andrew C.; Wei, Andrew H.; Dominguez, Pilar M.; Johnstone, Ricky W. 分享 收藏
Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations 小鼠和人类树突状细胞群之间STING诱导的激活和细胞死亡的不一致 Pang, Ee Shan; Daraj, Ghazal; Balka, Katherine R.; De Nardo, Dominic; Macri, Christophe; Hochrein, Hubertus; Masterman, Kelly-Anne; Tan, Peck S.; Shoppee, Angus; Magill, Zoe; Jahan, Nazneen; Bafit, Mariam; Zhan, Yifan; Kile, Benjamin T.; Lawlor, Kate E.; Radford, Kristen J.; Wright, Mark D.; O'Keeffe, Meredith 分享 收藏
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24 蛋白激酶R是通过胞质IL-24积累的蛋白毒性应激的先天免疫传感器 Davidson, Sophia; Yu, Chien-Hsiung; Steiner, Annemarie; Ebstein, Frederic; Baker, Paul J.; Jarur-Chamy, Valentina; Schaale, Katja Hrovat; Laohamonthonkul, Pawat; Kong, Klara; Calleja, Dale J.; Harapas, Cassandra R.; Balka, Katherine R.; Mitchell, Jacob; Jackson, Jacob T.; Geoghegan, Niall D.; Moghaddas, Fiona; Rogers, Kelly L.; Mayer-Barber, Katrin D.; De Jesus, Adriana A.; De Nardo, Dominic; Kile, Benjamin T.; Sadler, Anthony J.; Cecilia Poli, M.; Kruger, Elke; Mansky, Raphaela Goldbach; Masters, Seth L. 分享 收藏
Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy 急性髓系白血病成熟谱系影响分化治疗后的残留疾病和复发 Ngo, Steven; Oxley, Ethan P.; Ghisi, Margherita; Garwood, Maximilian M.; McKenzie, Mark D.; Mitchell, Helen L.; Kanellakis, Peter; Susanto, Olivia; Hickey, Michael J.; Perkins, Andrew C.; Kile, Benjamin T.; Dickins, Ross A. 分享 收藏
Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells 稳态凋亡可防止竞争诱导的滤泡b细胞萎缩 Chappaz, Stephane; McArthur, Kate; Kealy, Liam; Law, Charity W.; Tailler, Maximilien; Lane, Rachael M.; Lieschke, Anna; Ritchie, Matthew E.; Good-Jacobson, Kim L.; Strasser, Andreas; Kile, Benjamin T. 分享 收藏
An essential role for α4A-tubulin in platelet biogenesis (vol 13, e201900309, 2019) Strassel, Catherinei; Magiera, M. Maria; Dupuis, Arnaud; Batzenschlager, Morgane; Hovasse, Agnes; Pleines, Irina; Gueguen, Paul; Eckly, Anita; Moog, Sylvie; Mallo, Lea; Kimmerlin, Quentin; Chappaz, Stephane; Strub, Jean-Marc; Kathiresan, Natarajan; de la Salle, Henri; Van Dorsselaer, Alain; Ferec, Claude; Py, Jean-Yves; Gachet, Christian; Schaeffer-Reiss, Christine; Kile, Benjamin T.; Janke, Carsten; Lanza, Francois 分享 收藏
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