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R

Rachel A. Ridgway

cancer research uk scotland centre
H指数:47
被引数:1.1万

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Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state

病毒模拟将免疫抑制性结直肠癌景观重定向为促炎性和CMS1样再生状态

Communications Biology
IF5.1
2026-05-260
OAAI
Shania M. Corry; Svetlana Sakhnevych; Noha Ehssan Mohamed; Sudhir B. Malla; Ryan Byrne; Andrew Young; Raheleh Amirkhah; Courtney Bull; Andrea Lees; Keara Redmond; Tamsin R. M. Lannagan; Rachel A. Ridgway; Fiona R. Taggart; Natalie C. Fisher; Tim Maughan; Mark Lawler; Andrew D. Campbell; Simon J. Leedham; Aideen E. Ryan; Daniel B. Longley; Donna M. Small; Owen J. Sansom; Philip D. Dunne
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

核磷蛋白支持WNT驱动的过度增殖和肿瘤启动

Nature Genetics
IF29
2025-12-180
OAAI
Georgios Kanellos; Chiara Giacomelli; Alexander Raven; Nikola Vlahov; Hu Jin; Pauline Herviou; Sudhir B. Malla; Nadia Nasreddin; Patricia P. Centeno; Constantinos Alexandrou; Kathryn Gilroy; Rachel L. Baird; Kathryn Pennel; June Munro; Joseph A. Waldron; Holly Hall; Leah Officer-Jones; Sheila Bryson; Douglas Strathdee; Sergio Lilla; Sara Zanivan; Vivienne Morrison; Colin Nixon; Rachel A. Ridgway; Crispin Miller; John R. P. Knight; Andrew D. Campbell; Philip D. Dunne; John Le Quesne; Joanne Edwards; Peter J. Park; Martin Bushell; Owen J. Sansom
MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance

MAPK驱动的上皮细胞可塑性驱动结直肠癌治疗抵抗

Nature
IF48.5
2025-11-240
PRE
Mark White; Megan L. Mills; Laura M. Millett; Kathryn Gilroy; Yourae Hong; Lucas B. Zeiger; Rosalin J. Simpson; Shania M. Corry; Amelia Ligeza; Tamsin R. M. Lannagan; Susanti Susanti; Rachel A. Ridgway; Ayse S. Yazgili; Lucile Grzesiak; Raheleh Amirkhah; Catriona A. Ford; Nikola Vlahov; Hannah Tovell; Leah Officer-Jones; Catherine Ficken; Rachel Pennie; Arafath K. Najumudeen; Alexander Raven; Nadia Nasreddin; Ekansh Chauhan; Andrew S. Papanastasiou; Colin Nixon; Vivienne Morrison; Rene Jackstadt; Janet S. Graham; Crispin J. Miller; Sarah J. Ross; Simon T. Barry; Valeria Pavet; Richard H. Wilson; John Le Quesne; Philip D. Dunne; Sabine Tejpar; Simon Leedham; Andrew D. Campbell; Owen J. Sansom
Hepatic zonation determines tumorigenic potential of mutant β-catenin

肝区室分布决定了突变型β-catenin的致瘤潜能

Nature
IF48.5
2025-11-190
OA
Alexander Raven; Kathryn Gilroy; Hu Jin; Joseph A. Waldron; Holly Leslie; June Munro; Holly Hall; Rachel A. Ridgway; Catriona A. Ford; Doga C. Gulhan; Nikola Vlahov; Megan L. Mills; Andrew Hartley; Eve Anderson; Sheila Bryson; Nathalie Sphyris; Miryam Müller; Stephanie May; Barbara Cadden; Colin Nixon; Scott H. Waddell; Rachel Guest; Luke Boulter; Nick Barker; Hans Clevers; Hao Zhu; Johanna Ivaska; Douglas Strathdee; Crispin J. Miller; Nigel B. Jamieson; Martin Bushell; Peter J. Park; Thomas G. Bird; Owen J. Sansom
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling

上皮GREMLIN1通过基质重塑破坏肠上皮-间质细胞通讯，诱导Wnt依赖性的异位干细胞微环境。

Nature Communications
IF15.7
2025-06-040
OAAI
Eoghan J. Mulholland; Hayley L. Belnoue-Davis; Gabriel N. Valbuena; Nuray Gunduz; Amelia Ligeza; Muyang Lin; Sujata Biswas; Ester Gil Vasquez; Sulochana Omwenga; Nadia Nasreddin; Michael C. Hodder; Lai Mun Wang; Aik Seng Ng; Elizabeth Jennings; Kim S. Midwood; Neesha Dedi; Shazia Irshad; Rachel A. Ridgway; Toby J. Phesse; James East; Ian PM Tomlinson; Gareth CG Davies; Owen J. Sansom; Simon J. Leedham
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer (Vol 56, pg 458, 2024)
NATURE GENETICS
IF31.8
2024-06-031
OAAI
Malla, Sudhir B.; Byrne, Ryan M.; Lafarge, Maxime W.; Corry, Shania M.; Fisher, Natalie C.; Tsantoulis, Petros K.; Mills, Megan L.; Ridgway, Rachel A.; Lannagan, Tamsin R. M.; Najumudeen, Arafath K.; Gilroy, Kathryn L.; Amirkhah, Raheleh; Maguire, Sarah L.; Mulholland, Eoghan J.; Belnoue-Davis, Hayley L.; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; McCooey, Aoife J.; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D.; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B.; Kerr, Emma M.; Tejpar, Sabine; Maughan, Timothy S.; Lawler, Mark; Campbell, Andrew D.; Leedham, Simon J.; Koelzer, Viktor H.; Sansom, Owen J.; Dunne, Philip D.
Single cell RNA sequencing of human and murine cancers demonstrates metastases-specific neutrophil phenotypes driven by the IL-1β/CXCR2 signaling axis - Disruption of this pathway abrogates neutrophil immunosuppressive effects and reduces tumor burden
CANCER RESEARCH
IF16.6
2024-03-220
PRE
McLaren, Alistair S.; Fetit, Rana; White, Mark; Mills, Megan L.; Lannagan, Tamsin; Falconer, John; Cortes-Lavaud, Xabier; Gilroy, Kathryn; Ridgway, Rachel; Nixon, Colin; Naiker, Varushka; Njunge, Renee; Clarke, Cassie J.; Whyte, Declan; Kirschner, Kristina; Jackstadt, Rene; Norman, Jim C.; Carlin, Leo M.; Campbell, Andrew D.; Sansom, Owen J.; Steele, Colin W.
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
NATURE GENETICS
IF31.8
2024-02-1310
OAAI
Malla, Sudhir B.; Byrne, Ryan M.; Lafarge, Maxime W.; Corry, Shania M.; Fisher, Natalie C.; Tsantoulis, Petros K.; Mills, Megan L.; Ridgway, Rachel A.; Lannagan, Tamsin R. M.; Najumudeen, Arafath K.; Gilroy, Kathryn L.; Amirkhah, Raheleh; Maguire, Sarah L.; Mulholland, Eoghan J.; Belnoue-Davis, Hayley L.; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; Mccooey, Aoife J.; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D.; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B.; Kerr, Emma M.; Tejpar, Sabine; Maughan, Timothy S.; Lawler, Mark; Campbell, Andrew D.; Leedham, Simon J.; Koelzer, Viktor H.; Sansom, Owen J.; Dunne, Philip D.
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression
NATURE COMMUNICATIONS
IF15.7
2023-08-2512
OAAI
Bailey, Peter; Ridgway, Rachel A.; Cammareri, Patrizia; Treanor-Taylor, Mairi; Bailey, Ulla-Maja; Schoenherr, Christina; Bone, Max; Schreyer, Daniel; Purdie, Karin; Thomson, Jason; Rickaby, William; Jackstadt, Rene; Campbell, Andrew D.; Dimonitsas, Emmanouil; Stratigos, Alexander J.; Arron, Sarah T.; Wang, Jun; Blyth, Karen; Proby, Charlotte M.; Harwood, Catherine A.; Sansom, Owen J.; Leigh, Irene M.; Inman, Gareth J.
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

代谢谱分析将结直肠癌分层并揭示腺苷同型半胱氨酸酶作为治疗靶标

NATURE METABOLISM
IF20.8
2023-08-1413
OAAI
Voorde, Johan Vande; Steven, Rory T.; Najumudeen, Arafath K.; Ford, Catriona A.; Dexter, Alex; Gonzalez-Fernandez, Ariadna; Nikula, Chelsea J.; Xiang, Yuchen; Ford, Lauren; Stavrakaki, Stefania Maneta; Gilroy, Kathryn; Zeiger, Lucas B.; Pennel, Kathryn; Hatthakarnkul, Phimmada; Elia, Efstathios A.; Nasif, Ammar; Murta, Teresa; Manoli, Eftychios; Mason, Sam; Gillespie, Michael; Lannagan, Tamsin R. M.; Vlahov, Nikola; Ridgway, Rachel A.; Nixon, Colin; Raven, Alexander; Mills, Megan; Athineos, Dimitris; Kanellos, Georgios; Nourse, Craig; Gay, David M.; Hughes, Mark; Burton, Amy; Yan, Bin; Sellers, Katherine; Wu, Vincen; De Ridder, Kobe; Shokry, Engy; Uribe, Alejandro Huerta; Clark, William; Clark, Graeme; Kirschner, Kristina; Thienpont, Bernard; Li, Vivian S. W.; Maddocks, Oliver D. K.; Barry, Simon T.; Goodwin, Richard J. A.; Kinross, James; Edwards, Joanne; Yuneva, Mariia O.; Sumpton, David; Takats, Zoltan; Campbell, Andrew D.; Bunch, Josephine; Sansom, Owen J.
MmCMS: mouse models' consensus molecular subtypes of colorectal cancer
BRITISH JOURNAL OF CANCER
IF6.8
2023-01-3010
OA
Amirkhah, Raheleh; Gilroy, Kathryn; Malla, Sudhir B. B.; Lannagan, Tamsin R. M.; Byrne, Ryan M. M.; Fisher, Natalie C. C.; Corry, Shania M. M.; Mohamed, Noha-Ehssan; Naderi-Meshkin, Hojjat; Mills, Megan L. L.; Campbell, Andrew D. D.; Ridgway, Rachel A. A.; Ahmaderaghi, Baharak; Murray, Richard; Llergo, Antoni Berenguer; Sanz-Pamplona, Rebeca; Villanueva, Alberto; Batlle, Eduard; Salazar, Ramon; Lawler, Mark; Sansom, Owen J. J.; Dunne, Philip D. D.
Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

上皮tgf β 参与生长因子信号传导以避免细胞凋亡并以侵袭性特征驱动肠道肿瘤发生

NATURE COMMUNICATIONS
IF15.7
2022-12-074
OAAI
Flanagan, Dustin J.; Amirkhah, Raheleh; Vincent, David F.; Gunduz, Nuray; Gentaz, Pauline; Cammareri, Patrizia; McCooey, Aoife J.; McCorry, Amy M. B.; Fisher, Natalie C.; Davis, Hayley L.; Ridgway, Rachel A.; Lohuis, Jeroen; Leach, Joshua D. G.; Jackstadt, Rene; Gilroy, Kathryn; Mariella, Elisa; Nixon, Colin; Clark, William; Hedley, Ann; Markert, Elke K.; Strathdee, Douglas; Bartholin, Laurent; Redmond, Keara L.; Kerr, Emma M.; Longley, Daniel B.; Ginty, Fiona; Cho, Sanghee; Coleman, Helen G.; Loughrey, Maurice B.; Bardelli, Alberto; Maughan, Timothy S.; Campbell, Andrew D.; Lawler, Mark; Leedham, Simon J.; Barry, Simon T.; Inman, Gareth J.; van Rheenen, Jacco; Dunne, Philip D.; Sansom, Owen J.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
NATURE COMMUNICATIONS
IF15.7
2021-06-0842
OAAI
Leach, Joshua D. G.; Vlahov, Nikola; Tsantoulis, Petros; Ridgway, Rachel A.; Flanagan, Dustin J.; Gilroy, Kathryn; Sphyris, Nathalie; Vazquez, Ester G.; Vincent, David F.; Faller, William J.; Hodder, Michael C.; Raven, Alexander; Fey, Sigrid; Najumudeen, Arafath K.; Strathdee, Douglas; Nixon, Colin; Hughes, Mark; Clark, William; Shaw, Robin; van Hooff, Sander R.; Huels, David J.; Medema, Jan Paul; Barry, Simon T.; Frame, Margaret C.; Unciti-Broceta, Asier; Leedham, Simon J.; Inman, Gareth J.; Jackstadt, Rene; Thompson, Barry J.; Campbell, Andrew D.; Tejpar, Sabine; Sansom, Owen J.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

来自Apc突变细胞的NOTUM偏向克隆竞争引发癌症

Nature
IF48.5
2021-06-020
PREAI
Dustin J. Flanagan; Nalle Pentinmikko; Kalle Luopajärvi; Nicky J. Willis; Kathryn Gilroy; Alexander P. Raven; Lynn Mcgarry; Johanna I. Englund; Anna T. Webb; Sandra Scharaw; Nadia Nasreddin; Michael C. Hodder; Rachel A. Ridgway; Emma Minnee; Nathalie Sphyris; Ella Gilchrist; Arafath K. Najumudeen; Beatrice Romagnolo; Christine Perret; Ann C. Williams; Hans Clevers; Pirjo Nummela; Marianne Lähde; Kari Alitalo; Ville Hietakangas; Ann Hedley; William Clark; Colin Nixon; Kristina Kirschner; E. Yvonne Jones; Ari Ristimäki; Simon J. Leedham; Paul V. Fish; Jean-Paul Vincent; Pekka Katajisto; Owen J. Sansom
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
NATURE COMMUNICATIONS
IF15.7
2021-01-14161
OAAI
Tajan, Mylene; Hennequart, Marc; Cheung, Eric C.; Zani, Fabio; Hock, Andreas K.; Legrave, Nathalie; Maddocks, Oliver D. K.; Ridgway, Rachel A.; Athineos, Dimitris; Suarez-Bonnet, Alejandro; Ludwig, Robert L.; Novellasdemunt, Laura; Angelis, Nikolaos; Li, Vivian S. W.; Vlachogiannis, Georgios; Valeri, Nicola; Mainolfi, Nello; Suri, Vipin; Friedman, Adam; Manfredi, Mark; Blyth, Karen; Sansom, Owen J.; Vousden, Karen H.

研究方向

暂未获取到该数据
O
Owen J. Sansom
H 指数:113论文数:1,190被引数:5.1万
A
Andrew D. Campbell
H 指数:39论文数:325被引数:6,412
C
Colin Nixon
H 指数:56论文数:400被引数:1.2万
D
Dimitris Athineos
H 指数:34论文数:107被引数:8,402
K
Kathryn Gilroy
H 指数:19论文数:264被引数:2,270
J
Jennifer P. Morton
H 指数:77论文数:391被引数:2.4万
D
Douglas Strathdee
H 指数:27论文数:127被引数:4,251
H
Hans Clevers
H 指数:236论文数:1,340被引数:25.0万
D
David J. Huels
H 指数:18论文数:29被引数:3,405
A
Alan R. Clarke
H 指数:69论文数:384被引数:2.3万