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D

Dinesh Thummuri

University of Florida
H指数:30
被引数:3,126
浏览量:0

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Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
CELL DEATH DISCOVERY
IF7
2023-01-0220
OAAI
Khan, Sajid; Kellish, Patrick; Connis, Nick; Thummuri, Dinesh; Wiegand, Janet; Zhang, Peiyi; Zhang, Xuan; Budamagunta, Vivekananda; Hua, Nan; Yang, Yang; De, Umasankar; Jin, Lingtao; Zhang, Weizhou; Zheng, Guangrong; Hromas, Robert; Hann, Christine; Zajac-Kaye, Maria; Kaye, Frederic J.; Zhou, Daohong
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

XP-524是一种双重BET/EP300抑制剂，可抑制致癌KRAS并增强胰腺癌的免疫检查点抑制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2022-01-2125
OAAI
Principe, Daniel R.; Xiong, Rui; Li, Yangfeng; Pham, Thao N. D.; Kamath, Suneel D.; Dubrovskyi, Oleksii; Ratia, Kiira; Huang, Fei; Zhao, Jiong; Shen, Zhengnan; Thummuri, Dinesh; Zhou Daohong; Underwood, Patrick W.; Trevino, Jose; Munshi, Hidayatullah G.; Thatcher, Gregory R. J.; Rana, Ajay
Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216

使用bcl-xl特异性降解剂DT2216克服胰腺癌的吉西他滨耐药性

MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-10-1942
OAAI
Thummuri, Dinesh; Khan, Sajid; Underwood, Patrick W.; Zhang, Peiyi; Wiegand, Janet; Zhang, Xuan; Budamagunta, Vivekananda; Sobh, Amin; Tagmount, Abderrahmane; Loguinov, Alexander; Riner, Andrea N.; Akki, Ashwin S.; Williamson, Elizabeth; Hromas, Robert; Vulpe, Christopher D.; Zheng, Guangrong; Trevino, Jose G.; Zhou, Daohong
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
NATURE COMMUNICATIONS
IF15.7
2020-04-24159
OAAI
He, Yonghan; Zhang, Xuan; Chang, Jianhui; Kim, Ha-Neui; Zhang, Peiyi; Wang, Yingying; Khan, Sajid; Liu, Xingui; Zhang, Xin; Lv, Dongwen; Song, Lin; Li, Wen; Thummuri, Dinesh; Yuan, Yaxia; Wiegand, Janet S.; Ortiz, Yuma T.; Budamagunta, Vivekananda; Elisseeff, Jennifer H.; Campisi, Judith; Almeida, Maria; Zheng, Guangrong; Zhou, Daohong
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

选择性bcl-xl PROTAC降解剂可实现安全有效的抗肿瘤活性

NATURE MEDICINE
IF50
2019-12-02411
OAAI
Khan, Sajid; Zhang, Xuan; Lv, Dongwen; Zhang, Qi; He, Yonghan; Zhang, Peiyi; Liu, Xingui; Thummuri, Dinesh; Yuan, Yaxia; Wiegand, Janet S.; Pei, Jing; Zhang, Weizhou; Sharma, Abhisheak; McCurdy, Christopher R.; Kuruvilla, Vinitha M.; Baran, Natalia; Ferrando, Adolfo A.; Kim, Yong-mi; Rogojina, Anna; Houghton, Peter J.; Huang, Guangcun; Hromas, Robert; Konopleva, Marina; Zheng, Guangrong; Zhou, Daohong

研究方向

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G
Guangrong Zheng
H 指数:37论文数:236被引数:5,976
D
Daohong Zhou
H 指数:65论文数:278被引数:1.8万
V
V.G.M. Naidu
H 指数:50论文数:202被引数:7,267
张沛怡 封面图
张沛怡
H 指数:22论文数:94被引数:2,310
张
张翾
H 指数:45论文数:229被引数:6,635
S
Sajid Khan
H 指数:37论文数:194被引数:6,448
M
Manish Kumar Jeengar
H 指数:22论文数:57被引数:1,610
D
Dongwen Lv
H 指数:34论文数:68被引数:3,751
X
Xingui Liu
H 指数:18论文数:45被引数:2,500
Y
Yonghan He
H 指数:34论文数:130被引数:4,145