logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
D

Dominik Paquet

LMU Munich
H指数:22
被引数:3,904

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes

一种可重复使用的人脑组织三维模型，用于研究生理和疾病相关的微胶质细胞表型

Nature Neuroscience
IF20
2026-08-040
OA
Julien Klimmt; Carolina Cardoso Gonçalves; Jessica Valentina Montgomery; Stephan A. Müller; Merle Bublitz; Severin Filser; Lars Paeger; Brigitte Nuscher; Angelika Dannert; Sigrun Roeber; Veronica Pravata; Martina Schifferer; Joshua J. Shrouder; Nathalie Schulz; Judit González-Gallego; Silvia Cappello; Thomas Misgeld; Nikolaus Plesnila; Eduardo Beltrán; Jochen Herms; Elena De Domenico; Marc D. Beyer; Joachim L. Schultze; Christian Haass; Stefan F. Lichtenthaler; Caterina Carraro; Dominik Paquet
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling

卒中风险基因Foxf2通过Tie2信号维持脑内皮细胞功能

Nature Neuroscience
IF20
2025-12-150
OAAI
Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Mihail Ivilinov Todorov; Fatma Burcu Seker; Simon Frerich; Filippo M. Cernilogar; Luise Schröger; Rainer Malik; Jiayu Cao; Gemma Llovera; Stefan Roth; Ulrike Schillinger; Martina Schifferer; Azadeh Reyahi; Dennis Crusius; Liliana D. Pedro; Mikael Simons; Peter Carlsson; Ali Ertürk; Arthur Liesz; Gunnar Schotta; Nikolaus Plesnila; Stefan F. Lichtenthaler; Dominik Paquet; Martin Dichgans
A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions

完全由iPS细胞衍生的人血脑屏障3D模型，用于探索神经血管疾病的机制和治疗干预措施

Nature Neuroscience
IF20
2025-12-150
OAAI
Judit González-Gallego; Katalin Todorov-Völgyi; Stephan A. Müller; Sophie Antesberger; Mihail Ivilinov Todorov; Rainer Malik; Rita Grimalt-Mirada; Carolina Cardoso Gonçalves; Martina Schifferer; Georg Kislinger; Isabel Weisheit; Barbara Lindner; Dennis Crusius; Joseph Kroeger; Mila Borri; Ali Erturk; Mark Nelson; Thomas Misgeld; Stefan F. Lichtenthaler; Martin Dichgans; Dominik Paquet
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds (vol 17, 49, 2025)

γ-分泌酶调节剂抵抗性在一种具有攻击性的阿尔茨海默病致病性早衰素突变体中，可以通过一组先进化合物在杂合患者状态下被克服（卷17，49，2025）

ALZHEIMERS RESEARCH & THERAPY
IF7.6
2025-04-150
OA
Trambauer, J; Sarmiento, RMR; Garringer, HJ; Salbaum, K; Pedro, LD; Crusius, D; Vidal, R; Ghetti, B; Paquet, D; Baumann, K; Lindemann, L; Steiner, H
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-12-040
PRE
Dinkel, Lina; Hummel, Selina; Zenatti, Valerio; Malara, Mariagiovanna; Tillmann, Yannik; Colombo, Alessio; Monasor, Laura Sebastian; Suh, Jung H.; Logan, Todd; Roth, Stefan; Paeger, Lars; Hoffelner, Patricia; Bludau, Oliver; Schmidt, Andree; Mueller, Stephan A.; Schifferer, Martina; Nuscher, Brigitte; Njavro, Jasenka Rudan; Prestel, Matthias; Bartos, Laura M.; Wind-Mark, Karin; Slemann, Luna; Hoermann, Leonie; Kunte, Sebastian T.; Gnoerich, Johannes; Lindner, Simon; Simons, Mikael; Herms, Jochen; Paquet, Dominik; Lichtenthaler, Stefan F.; Bartenstein, Peter; Franzmeier, Nicolai; Liesz, Arthur; Grosche, Antje; Bremova-Ertl, Tatiana; Catarino, Claudia; Beblo, Skadi; Bergner, Caroline; Schneider, Susanne A.; Strupp, Michael; Di Paolo, Gilbert; Brendel, Matthias; Tahirovic, Sabina
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-06-050
PRE
Reich, Marvin; Simon, Matthew J.; Polke, Beate; Paris, Inaki; Werner, Georg; Schrader, Christian; Spieth, Lena; Davis, Sonnet S.; Robinson, Sophie; de Melo, Gabrielly Lunkes; Schlaphoff, Lennart; Buschmann, Katrin; Berghoff, Stefan; Logan, Todd; Nuscher, Brigitte; de Weerd, Lis; Edbauer, Dieter; Simons, Mikael; Suh, Jung H.; Sandmann, Thomas; Kariolis, Mihalis S.; Devos, Sarah L.; Lewcock, Joseph W.; Paquet, Dominik; Capell, Anja; Di Paolo, Gilbert; Haass, Christian
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

单细胞转录图谱指导car-t细胞治疗急性髓系白血病的开发

NATURE BIOTECHNOLOGY
IF41.7
2023-03-1336
OAAI
Gottschlich, Adrian; Thomas, Moritz; Gruenmeier, Ruth; Lesch, Stefanie; Rohrbacher, Lisa; Igl, Veronika; Briukhovetska, Daria; Benmebarek, Mohamed-Reda; Vick, Binje; Dede, Sertac; Mueller, Katharina; Xu, Tao; Dhoqina, Dario; Maerkl, Florian; Robinson, Sophie; Sendelhofert, Andrea; Schulz, Heiko; Umut, Oeykue; Kavaka, Vladyslav; Tsiverioti, Christina Angeliki; Carlini, Emanuele; Nandi, Sayantan; Strzalkowski, Thaddaeus; Lorenzini, Theo; Stock, Sophia; Mueller, Philipp Jie; Doerr, Janina; Seifert, Matthias; Cadilha, Bruno L.; Brabenec, Ruben; Roeder, Natalie; Rataj, Felicitas; Nueesch, Manuel; Modemann, Franziska; Wellbrock, Jasmin; Fiedler, Walter; Kellner, Christian; Beltran, Eduardo; Herold, Tobias; Paquet, Dominik; Jeremias, Irmela; von Baumgarten, Louisa; Endres, Stefan; Subklewe, Marion; Marr, Carsten; Kobold, Sebastian
A reference human induced pluripotent stem cell line for collaborative studies

用于合作研究的参考人类诱导多能干细胞系

CELL STEM CELL
IF20.4
2022-12-0163
OA
Pantazis, Caroline B.; Yang, Andrian; Lara, Erika; McDonough, Justin A.; Blauwendraat, Cornelis; Peng, Lirong; Oguro, Hideyuki; Kanaujiya, Jitendra; Zou, Jizhong; Sebesta, David; Pratt, Gretchen; Cross, Erin; Blockwick, Jeffrey; Buxton, Philip; Kinner-Bibeau, Lauren; Medura, Constance; Tompkins, Christopher; Hughes, Stephen; Santiana, Marianita; Faghri, Faraz; Nalls, Mike A.; Vitale, Daniel; Ballard, Shannon; Qi, Yue A.; Ramos, Daniel M.; Anderson, Kailyn M.; Stadler, Julia; Narayan, Priyanka; Papademetriou, Jason; Reilly, Luke; Nelson, Matthew P.; Aggarwal, Sanya; Rosen, Leah U.; Kirwan, Peter; Pisupati, Venkat; Coon, Steven L.; Scholz, Sonja W.; Priebe, Theresa; Ottl, Miriam; Dong, Jian; Meijer, Marieke; Janssen, Lara J. M.; Lourenco, Vanessa S.; van der Kant, Rik; Crusius, Dennis; Paquet, Dominik; Raulin, Ana-Caroline; Bu, Guojun; Held, Aaron; Wainger, Brian J.; Gabriele, Rebecca M. C.; Casey, Jackie M.; Wray, Selina; Abu-Bonsrah, Dad; Parish, Clare L.; Beccari, Melinda S.; Cleveland, Don W.; Li, Emmy; Rose, Indigo V. L.; Kampmann, Martin; Aristoy, Carles Calatayud; Verstreken, Patrik; Heinrich, Laurin; Chen, Max Y.; Schule, Birgitt; Dou, Dan; Holzbaur, Erika L. F.; Zanellati, Maria Clara; Basundra, Richa; Deshmukh, Mohanish; Cohen, Sarah; Khanna, Richa; Raman, Malavika; Nevin, Zachary S.; Matia, Madeline; Van Lent, Jonas; Timmerman, Vincent; Conklin, Bruce R.; Chase, Katherine Johnson; Zhang, Ke; Funes, Salome; Bosco, Daryl A.; Erlebach, Lena; Welzer, Marc; Kronenberg-Versteeg, Deborah; Lyu, Guochang; Arenas, Ernest; Coccia, Elena; Sarrafha, Lily; Ahfeldt, Tim; Marioni, John C.; Skarnes, William C.; Cookson, Mark R.; Ward, Michael E.; Merkle, Florian T.
TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease
EMBO MOLECULAR MEDICINE
IF8.3
2022-08-0525
OAAI
Scotto Rosato, Anna; Krogsaeter, Einar K.; Jaslan, Dawid; Abrahamian, Carla; Montefusco, Sandro; Soldati, Chiara; Spix, Barbara; Pizzo, Maria Teresa; Grieco, Giuseppina; Boeck, Julia; Wyatt, Amanda; Wuenkhaus, Daniela; Passon, Marcel; Stieglitz, Marc; Keller, Marco; Hermey, Guido; Markmann, Sandra; Gruber-Schoffnegger, Doris; Cotman, Susan; Johannes, Ludger; Crusius, Dennis; Boehm, Ulrich; Wahl-Schott, Christian; Biel, Martin; Bracher, Franz; De Leonibus, Elvira; Polishchuk, Elena; Medina, Diego L.; Paquet, Dominik; Grimm, Christian
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

在颗粒蛋白前体缺乏症模型中，TREM2的缺失可挽救小胶质细胞的过度活化，但溶酶体缺陷和神经毒性却无法挽救。

EMBO JOURNAL
IF8.3
2022-01-1241
OAAI
Reifschneider, Anika; Robinson, Sophie; van Lengerich, Bettina; Gnoerich, Johannes; Logan, Todd; Heindl, Steffanie; Vogt, Miriam A.; Weidinger, Endy; Riedl, Lina; Wind, Karin; Zatcepin, Artem; Pesaemaa, Ida; Haberl, Sophie; Nuscher, Brigitte; Kleinberger, Gernot; Klimmt, Julien; Goetzl, Julia K.; Liesz, Arthur; Buerger, Katharina; Brendel, Matthias; Levin, Johannes; Diehl-Schmid, Janine; Suh, Jung; Di Paolo, Gilbert; Lewcock, Joseph W.; Monroe, Kathryn M.; Paquet, Dominik; Capell, Anja; Haass, Christian
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

他莫昔芬的再利用改善了CLN3和CLN7疾病表型

EMBO MOLECULAR MEDICINE
IF8.3
2021-08-1932
OAAI
Soldati, Chiara; Lopez-Fabuel, Irene; Wanderlingh, Luca G.; Garcia-Macia, Marina; Monfregola, Jlenia; Esposito, Alessandra; Napolitano, Gennaro; Guevara-Ferrer, Marta; Scotto Rosato, Anna; Krogsaeter, Einar K.; Paquet, Dominik; Grimm, Christian M.; Montefusco, Sandro; Braulke, Thomas; Storch, Stephan; Mole, Sara E.; De Matteis, Maria A.; Ballabio, Andrea; Sampaio, Julio L.; McKay, Tristan; Johannes, Ludger; Bolanos, Juan P.; Medina, Diego L.

研究方向

暂未获取到该数据
D
Dennis Crusius
H 指数:7论文数:20被引数:558
M
Martina Schifferer
H 指数:26论文数:94被引数:4,241
C
Christian Haass
H 指数:135论文数:669被引数:7.5万
S
Stephan A. Müller
H 指数:39论文数:204被引数:5,334
S
Stefan F. Lichtenthaler
H 指数:65论文数:326被引数:1.3万
M
Martin Dichgans
H 指数:143论文数:1,461被引数:10.2万
R
Rainer Malik
H 指数:72论文数:248被引数:2.0万
S
Sophie Robinson
H 指数:11论文数:23被引数:897
M
Mikael Simons
H 指数:84论文数:240被引数:3.5万
J
Julien Klimmt
H 指数:7论文数:12被引数:294