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Functionally Characterizing the Renal Cell Carcinoma Tumor-Immune Microenvironment via Patient-Derived Ex Vivo Models 通过患者来源的离体模型对肾细胞癌肿瘤免疫微环境进行功能表征 Sirc, Neja; Smolander, Johannes; Kumari, Anita N.; Liu, Jianyin; Lee, Moon Hee; Lahdensuo, Kanerva; Jarvinen, Riikka; Tornberg, Sara V.; Lin, Linh; Laitinen, Hanna K.; Theodoropoulos, Jason; Klievink, Jay; Mirtti, Tuomas; Kreutzman, Anna S.; Haikala, Heidi M.; Jarvinen, Petrus; Mustjoki, Satu; Peltonen, Karita 分享 收藏
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Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses Turpin, Rita; Peltonen, Karita; Rannikko, Jenna H.; Liu, Ruixian; Kumari, Anita N.; Nicorici, Daniel; Lee, Moon Hee; Mutka, Minna; Kovanen, Panu E.; Niinikoski, Laura; Meretoja, Tuomo; Mattson, Johanna; Jarvinen, Petrus; Lahdensuo, Kanerva; Jarvinen, Riikka; Tornberg, Sara; Mirtti, Tuomas; Bostrom, Pia; Koskivuo, Ilkka; Thotakura, Anil; Pouwels, Jeroen; Hollmen, Maija; Mustjoki, Satu; Klefstroem, Juha 分享 收藏
Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma 双重特异性STAT3/5降解剂有效阻断急性髓系白血病和自然杀伤/T细胞淋巴瘤 Poloske, Daniel; Sorger, Helena; Schoenbichler, Anna; de Araujo, Elvin D.; Neubauer, Heidi A.; Orlova, Anna; Timonen, Sanna H.; Abdallah, Diaaeldin I.; Ianevski, Aleksandr; Kuusanmaki, Heikki; Surbek, Marta; Heyes, Elisabeth; Eder, Thomas; Wagner, Christina; Suske, Tobias; Metzelder, Martin L.; Bergmann, Michael; Dahlhoff, Maik; Grebien, Florian; Fleck, Roman; Pirker, Christine; Berger, Walter; Hadzijusufovic, Emir; Sperr, Wolfgang R.; Kenner, Lukas; Valent, Peter; Aittokallio, Tero; Herling, Marco; Mustjoki, Satu; Gunning, Patrick T.; Moriggl, Richard 分享 收藏
Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response 慢性粒细胞白血病的单细胞多组学分析将细胞异质性与治疗反应联系起来 Warfvinge, Rebecca; Ulfsson, Linda Geironson; Dhapola, Parashar; Safi, Fatemeh; Sommarin, Mikael; Soneji, Shamit; Hjorth-Hansen, Henrik; Mustjoki, Satu; Richter, Johan; Thakur, Ram Krishna; Karlsson, Goran 分享 收藏
Computational Cytomorphological Analyses Identifies Bone Marrow Erythroblast Proportion As a Biomarker of Treatment-Free Remission in CML 计算细胞形态学分析将骨髓红细胞比例鉴定为CML治疗无复发的生物标志物 Purhonen, Mikko; Tatun, Mikael; Hung, Kevin; Tafjord, Oda; Adnan-Awad, Shady; Koskenvesa, Perttu; Siitonen, Sanna; Porkka, Kimmo; Mustjoki, Satu; Danielsson, Signe; Hjorth-Hansen, Henrik; Olsson-Stromberg, Ulla; Kumagai, Takashi; Kimura, Shinya; Ross, David M.; Bruck, Oscar E. 分享 收藏
Predicting Antigen-Specific T Cell Immunity Against Wilms Tumor 1 in Hematologic Cancer 预测针对Wilms Tumor 1的抗原特异性T细胞免疫在血液系统癌症中的作用 Jokinen, Emmi; Ford, Brittany; Huuhtanen, Jani; Forsten, Sofia; Klievink, Jay; Antignani, Gabriella; Bruck, Oscar E.; Cerullo, Vincenzo; Peltonen, Karita; Mustjoki, Satu 分享 收藏
Ex vivo modeling of precision immuno-oncology responses in lung cancer 肺癌精确免疫肿瘤学反应的离体建模 Alsaed, Bassel; Smolander, Johannes; Laitinen, Hanna; Lin, Linh; Bobik, Nina; Lahtinen, Lilja; Rasanen, Mikko; Jansouz, Shadi; Peltonen, Karita; Jokinen, Emmi; Klievink, Jay; Ganesh, Keerthana; Ainola, Mari; Sutinen, Eva; Ronty, Mikko; Narvi, Elli; Thotakura, Anil; Saharinen, Pipsa; Mustjoki, Satu; Ilonen, Ilkka; Haikala, Heidi M. 分享 收藏
Phase II study of nivolumab and relatlimab utilizing single cell analysis of circulating T cells reveals immune features associated with response to dual PD-1 and LAG-3 inhibition 一项利用循环T细胞单细胞分析的尼沃鲁单抗和瑞拉利单抗II期研究，揭示了与双重PD-1和LAG-3抑制反应相关的免疫特征 Dollar, J. J.; Decatur, C.; Salazar, S.; Cetta, N.; Huuhtanen, J.; Estevez, C.; Cruz, A.; Durante, M.; Mustjoki, S.; Correa, Z.; Harbour, J. W.; Lutzky, J. 分享 收藏
Somatic mutations associate with clonal expansion of CD8+ T cells 体细胞突变与CD8 T细胞的克隆扩增有关 Lundgren, Sofie; Myllymaki, Mikko; Jarvinen, Timo; Keraenen, Mikko A. I.; Theodoropoulos, Jason; Smolander, Johannes; Kim, Daehong; Salmenniemi, Urpu; Walldin, Gunilla; Savola, Paula; Kelkka, Tiina; Rajala, Hanna; Hellstroem-Lindberg, Eva; Itala-Remes, Maija; Kankainen, Matti; Mustjoki, Satu 分享 收藏
Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia 综合药物分析和CRISPR筛选确定BCR:: 慢性粒细胞白血病的ABL1-independent脆弱性 Awad, Shady Adnan; Dufva, Olli; Klievink, Jay; Karjalainen, Ella; Ianevski, Aleksandr; Pietarinen, Paavo; Kim, Daehong; Potdar, Swapnil; Wolf, Maija; Lotfi, Kourosh; Aittokallio, Tero; Wennerberg, Krister; Porkka, Kimmo; Mustjoki, Satu 分享 收藏
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia 过度活跃的STAT5劫持T细胞受体信号并驱动未成熟的T细胞急性淋巴细胞白血病 Suske, Tobias; Sorger, Helena; Manhart, Gabriele; Ruge, Frank; Prutsch, Nicole; Zimmerman, Mark W.; Eder, Thomas; Abdallah, Diaaeldin I.; Maurer, Barbara; Wagner, Christina; Schoenefeldt, Susann; Spirk, Katrin; Pichler, Alexander; Pemovska, Tea; Schweicker, Carmen; Poeloeske, Daniel; Hubanic, Emina; Jungherz, Dennis; Mueller, Tony Andreas; Aung, Myint Myat Khine; Orlova, Anna; Pham, Ha Thi Thanh; Zimmel, Kerstin; Krausgruber, Thomas; Bock, Christoph; Mueller, Mathias; Dahlhoff, Maik; Boersma, Auke; Ruelicke, Thomas; Fleck, Roman; Araujo, Elvin Dominic de; Gunning, Patrick Thomas; Aittokallio, Tero; Mustjoki, Satu; Sanda, Takaomi; Hartmann, Sylvia; Grebien, Florian; Hoermann, Gregor; Haferlach, Torsten; Staber, Philipp Bernhard; Neubauer, Heidi Anne; Look, Alfred Thomas; Herling, Marco; Moriggl, Richard 分享 收藏
Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment 呼吸复合物I在人肿瘤免疫微环境的外植体模型中调节树突状细胞的成熟 Turpin, Rita; Liu, Ruixian; Munne, Pauliina M.; Peura, Aino; Rannikko, Jenna H.; Philips, Gino; Boeckx, Bram; Salmelin, Natasha; Hurskainen, Elina; Suleymanova, Ilida; Aung, July; Vuorinen, Elisa M.; Lehtinen, Laura; Mutka, Minna; Kovanen, Panu E.; Niinikoski, Laura; Meretoja, Tuomo J.; Mattson, Johanna; Mustjoki, Satu; Saavalainen, Paeivi; Goga, Andrei; Lambrechts, Diether; Pouwels, Jeroen; Hollmen, Maija; Klefstrom, Juha 分享 收藏
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Correction: Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial (Jan, 10.1038/s41375-024-02145-6 , 2024) 更正: 用达沙替尼再次治疗的慢性粒细胞白血病患者第二次TKI停药尝试后的无治疗缓解-DAstop2试验的中期结果 (1月，10.1038/s41375-024-02145-6，2024) Flygt, Hjalmar; Soederlund, Stina; Richter, Johan; Saussele, Susanne; Koskenvesa, Perttu; Stenke, Leif; Mustjoki, Satu; Dimitrijevic, Andreja; Stentoft, Jesper; Majeed, Waleed; Roy, Lydia; Wolf, Dominik; Dreimane, Arta; Gjertsen, Bjorn Tore; Gedde-Dahl, Tobias; Ahlstrand, Erik; Markevaern, Berit; Hjorth-Hansen, Henrik; Janssen, Jeroen; Olsson-Stroemberg, Ulla 分享 收藏
Tracing back primed resistance in cancer via sister cells 通过姐妹细胞追溯癌症中引发的耐药性 Dai, Jun; Zheng, Shuyu; Falco, Matias M.; Bao, Jie; Eriksson, Johanna; Pikkusaari, Sanna; Forsten, Sofia; Jiang, Jing; Wang, Wenyu; Gao, Luping; Perez-Villatoro, Fernando; Dufva, Olli; Saeed, Khalid; Wang, Yinyin; Amiryousefi, Ali; Farkkila, Anniina; Mustjoki, Satu; Kauppi, Liisa; Tang, Jing; Vaharautio, Anna 分享 收藏
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