Jih‐Hwa Guh - Publications, H-index & Citations

Jih‐Hwa Guh

National Taiwan University

44H指数

226论文数

5.8K被引数

收录论文 121

发表时间

Establishing a noncanonical zinc-binding group as a selective histone deacetylase inhibitor and possible novel anticancer agent 建立一种非经典锌结合基团作为选择性组蛋白去乙酰化酶抑制剂及可能的抗癌新药

Bioorganic Chemistry

IF4.7

2025-08-27

PREAI

Hsuan-Chun Huang; Tse-Yu Chen; Tsung-Yu Yeh; Min-Hsuan Yu; Sian-Siou Wu; Guang-Yi Li; Bo-Yu Chen; Miao-Hsia Lin; Ching-Jung Lin; Jui-Ling Hsu; Jih-Hwa Guh; Chao-Wu Yu

Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation 通过钯催化二聚化设计并合成新型HDAC6抑制剂二聚体，作为HDAC6降解剂用于癌症治疗

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2025-02-27

OAAI

Ching Lin; Jui-Ling Hsu; Yu-Tung Hsu; Kuo-Chen Fan; Sian-Siou Wu; Miao-Hsia Lin; Jih-Hwa Guh; Chao-Wu Yu

Repurposing Suan-Zao-Ren-Tang as anticancer agents in apoptotic sensitization against non-small cell lung cancer cell lines through amplification of spindle assembly checkpoint activation 通过增强有丝分裂纺锤体组装检验点的激活，将酸枣仁汤重新用于诱导非小细胞肺癌细胞系凋亡敏感化的抗癌剂。

Journal of Traditional and Complementary Medicine

IF3

2024-08-29

OAAI

Yu-Chi Hsiao; Yi-Hua Sheng; Tse-Yu Chen; Wohn-Jenn Leu; Jui-Ling Hsu; Lih-Ching Hsu; Lie-Chwen Lin; Jih-Hwa Guh

Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin

BIOCHEMICAL PHARMACOLOGY

IF5.6

2024-05-01

PREAI

Huang, Haoning; Kung, Fan-Lu; Huang, Yu-Wen; Hsu, Chun-Chien; Guh, Jih-Hwa; Hsu, Lih-Ching

Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2024-03-07

PREAI

Du, Chi-Min; Leu, Wohn-Jenn; Jiang, Yi-Huei; Chan, She-Hung; Chen, Ih-Sheng; Chang, Hsun-Shuo; Hsu, Lih-Ching; Hsu, Jui-Ling; Guh, Jih-Hwa

Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3-c]quinolin-12(12H)-one as potential breast cancer drugs

ARABIAN JOURNAL OF CHEMISTRY

IF5.2

2024-01-01

OAAI

Sumitra, Maryam Rachmawati; Chen, Lung-Ching; Tsai, Wei-Chen; Ansar, Muhamad; Lawal, Bashir; Mokgautsi, Ntlotlang; Guh, Jih-Hwa; Wu, Alexander T. H.; Huang, Hsu-Shan

Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells

MOLECULES

IF4.6

2023-03-03

OAAI

Hsu, Ya-Fen; Kung, Fan-Lu; Huang, Tzu-En; Deng, Yi-Ning; Guh, Jih-Hwa; Marchetti, Paolo; Marchesi, Elena; Perrone, Daniela; Navacchia, Maria Luisa; Hsu, Lih-Ching

Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays

MOLECULES

IF4.6

2022-11-21

OAAI

Hung, Hsueh-Chih; Li, Li-Cheng; Guh, Jih-Hwa; Kung, Fan-Lu; Hsu, Lih-Ching

Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

MOLECULES

IF4.6

2021-10-01

OAAI

Hsu, Jui-Ling; Leu, Wohn-Jenn; Zhong, Nan-Shan; Guh, Jih-Hwa

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies

MOLECULES

IF4.6

2020-12-16

OAAI

Leu, Wohn-Jenn; Chu, Jung-Chun; Hsu, Jui-Ling; Du, Chi-Min; Jiang, Yi-Huei; Hsu, Lih-Ching; Huang, Wei-Jan; Guh, Jih-Hwa

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

CELL CHEMICAL BIOLOGY

IF7.2

2020-11-01

OAAI

Wang, Yuezhou; Zhang, Lei; Wei, Yanling; Huang, Wei; Li, Li; Wu, An-an; Dastur, Anahita; Greninger, Patricia; Bray, Walter M.; Zhang, Chen-Song; Li, Mengqi; Lian, Wenhua; Hu, Zhiyu; Wang, Xiaoyong; Liu, Gang; Yao, Luming; Guh, Jih-Hwa; Chen, Lanfen; Wang, Hong-Rui; Zhou, Dawang; Lin, Sheng-Cai; Xu, Qingyan; Shen, Yuemao; Zhang, Jianming; Jurica, Melissa S.; Benes, Cyril H.; Deng, Xianming

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

FRONTIERS IN ONCOLOGY

IF3.3

2020-08-07

OAAI

Hsu, Jui-Ling; Leu, Wohn-Jenn; Hsu, Lih-Ching; Ho, Chen-Hsun; Liu, Shih-Ping; Guh, Jih-Hwa

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

MOLECULES

IF4.6

2020-06-25

OAAI

Sheng, Yi-Hua; Leu, Wohn-Jenn; Chen, Ching-Nung; Hsu, Jui-Ling; Liu, Ying-Tung; Hsu, Lih-Ching; Hou, Duen-Ren; Guh, Jih-Hwa

Synthesis and biological evaluation of anthra [1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

ARABIAN JOURNAL OF CHEMISTRY

IF5.2

2019-12-01

OAAI

Chen, Tsung-Chih; Guh, Jih-Hwa; Hsu, Hui-Wen; Chen, Chun-Liang; Lee, Chia-Chung; Wu, Chia-Lun; Lee, Yu-Ru; Lin, Jing-Jer; Yu, Dah-Shyong; Huang, Hsu-Shan

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

ARABIAN JOURNAL OF CHEMISTRY

IF5.2

2019-12-01

OAAI

Chen, Tsung-Chih; Yu, Dah-Shyong; Chen, Shiag-Jiun; Chen, Chun-Liang; Lee, Chia-Chung; Hsieh, Ying-Yu; Chang, Lien-Cheng; Guh, Jih-Hwa; Lin, Jing-Jer; Huang, Hsu-Shan

Antileukemic activity and mechanism of ardisianone-a crucial role of mitochondrial stress in apoptosis and necroptosis

ANNALS OF ONCOLOGY

IF65.4

2019-10-01

OAAI

Chan, She-Hung; Guh, Jih-Hwa

Dihydroartemisinin-Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity

CHEMMEDCHEM

IF3.4

2019-04-04

OAAI

Marchesi, Elena; Chinaglia, Nicola; Capobianco, Massimo L.; Marchetti, Paolo; Huang, Tzu-En; Weng, Hao-Cheng; Guh, Jih-Hwa; Hsu, Lih-Ching; Perrone, Daniela; Navacchia, Maria Luisa

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

FRONTIERS IN ONCOLOGY

IF3.3

2019-01-17

OAAI

Chang, Jo-Fan; Hsu, Jui-Ling; Sheng, Yi-Hua; Leu, Wohn-Jenn; Yu, Chia-Chun; Chan, She-Hung; Chan, Mei-Ling; Hsu, Lih-Ching; Liu, Shih-Ping; Guh, Jih-Hwa

RETRACTION: Development of Novel Adenosine Monophosphate-Activated Protein Kinase Activators (Retraction of Vol 53, Pg 2552, 2010)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-05-18

PREAI

Guh, Jih-Hwa; Chang, Wei-Ling; Yang, Jian; Lee, Su-Lin; Wei, Shuo; Wang, Dasheng; Kulp, Samuel K.; Chen, Ching-Shih

An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2018-03-28

PREAI

Chan, She-Hung; Liang, Pi-Hui; Guh, Jih-Hwa

研究方向