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J

Jessica R. Kirshner

regeneron pharmaceuticals inc.
H指数:22
被引数:3,517

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CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo

基于全人源T细胞受体模拟抗体的CAR T细胞在体内表现出强大的抗肿瘤活性。

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2025-03-260
PRE
Salzler, Robert; Dilillo, David J.; Saotome, Kei; Bray, Kevin; Mohrs, Katja; Hwang, Haun; Cygan, Kamil J.; Shah, Darshit; Rye-Weller, Anna; Kundu, Kunal; Badithe, Ashok; Zhang, Xiaoqin; Garnova, Elena; Torres, Marcela; Dhanik, Ankur; Babb, Robert; Delfino, Frank J.; Thwaites, Courtney; Dudgeon, Drew; Moore, Michael J.; Meagher, Thomas Craig; Decker, Corinne E.; Owczarek, Tomasz; Gleason, John A.; Yang, Xiaoran; Suh, David; Lee, Wen-Yi; Welsh, Richard; Macdonald, Douglas; Hansen, Johanna; Guo, Chunguang; Kirshner, Jessica R.; Thurston, Gavin; Huang, Tammy; Franklin, Matthew C.; Yancopoulos, George D.; Lin, John C.; Macdonald, Lynn E.; Murphy, Andrew J.; Chen, Gang; Olsen, Olav; Olson, William C.
REGN10597: A PD-1-targeted, receptor-masked wild type IL-2 with improved therapeutic window for cancer immunotherapy
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Wu, Jiaxi; Bloch, Nicolin; Chang, Aaron; Bhaysar, Ramandeep; Wang, Qingqing; Patel, Supriya; Garg, Vidur; Shakil, Hassan; Amatulli, Michael; Dudgeon, Drew; Yan, Yuetian; Wang, Shunhai; Ramos, Willy; Krueger, Pamela; Vazzana, Kristin; Crawford, Alison; Idun, Jacqueline; Decker, Corinne; DiLillo, David; Chandwani, Samira; Huang, Tammy; Kirshner, Jessica; Guo, Chungguang; Macdonald, Lynn; Ullman, Erica; Hermann, Aynur; Olson, William; Davis, Samuel; Lin, John; Smith, Eric; Zhang, Tong
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

通过CD3亲和力调节产生具有细胞因子释放和生物分布的分化特征的T细胞重定向双特异性抗体

SCIENTIFIC REPORTS
IF3.9
2021-07-1364
OAAI
Haber, Lauric; Olson, Kara; Kelly, Marcus P.; Crawford, Alison; DiLillo, David J.; Tavare, Richard; Ullman, Erica; Mao, Shu; Canova, Lauren; Sineshchekova, Olga; Finney, Jennifer; Pawashe, Arpita; Patel, Supriya; McKay, Ryan; Rizvi, Sahar; Damko, Ermelinda; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; D'Orvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Chen, Ya Ping; Thwaites, Courtney; Dudgeon, Drew; Bray, Kevin; Rafique, Ashique; Huang, Tammy; Delfino, Frank; Hermann, Aynur; Kirshner, Jessica R.; Retter, Marc W.; Babb, Robert; MacDonald, Douglas; Chen, Gang; Olson, William C.; Thurston, Gavin; Davis, Samuel; Lin, John C.; Smith, Eric
Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids

可裂解的氨基-苯甲酰基-美登素类化合物的抗体药物缀合物

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2020-12-012
PREAI
Nittoli, Thomas; Delfino, Frank; Kelly, Marcus; Carosso, Serena; Markotan, Thomas; Kunz, Arthur; Chen, Zhaoyuan; Mao, Shu; Shan, Jing; Navarro, Elizabeth; Zhao, Feng; Makonnen, Sosina; Hickey, Carlos; Spink, Jan; Olson, William; Kirshner, Jessica R.; Thurston, Gavin; Papadopoulos, Nicholas
Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties
CANCER RESEARCH
IF16.6
2020-08-151
PRE
Haber, Lauric; Olson, Kara; Babb, Robert; Kelly, Marcus; Crawford, Alison; Retter, Marc; DiLillo, David; Ullman, Erica; Finney, Jennifer; Canova, Lauren; Pawashe, Arpita; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; Dorvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Patel, Supriya; Tavare, Richard; Chen, Ya Ping; Chen, Gang; Olson, William; Thurston, Gavin; Lin, John Chia-Yang; Hermann, Aynur; Kirshner, Jessica; Smith, Eric J.
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

一类增强CD3-bispecific抗体抗肿瘤活性的共刺激CD28-bispecific抗体

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-01-0894
OAAI
Skokos, Dimitris; Waite, Janelle C.; Haber, Lauric; Crawford, Alison; Hermann, Aynur; Ullman, Erica; Slim, Rabih; Godin, Stephen; Ajithdoss, Dharani; Ye, Xuan; Wang, Bei; Wu, Qi; Ramos, Ilyssa; Pawashe, Arpita; Canova, Lauren; Vazzana, Kristin; Ram, Priyanka; Herlihy, Evan; Ahmed, Hassan; Oswald, Erin; Golubov, Jacquelynn; Poon, Patrick; Havel, Lauren; Chiu, Danica; Lazo, Miguel; Provoncha, Kathleen; Yu, Kevin; Kim, Julie; Warsaw, Jacqueline J.; Oristian, Nicole Stokes; Siao, Chia-Jen; Dudgeon, Drew; Huang, Tammy; Potocky, Terra; Martin, Joel; MacDonald, Douglas; Oyejide, Adelekan; Rafique, Ashique; Poueymirou, William; Kirshner, Jessica R.; Smith, Eric; Olson, William; Lin, John; Thurston, Gavin; Sleeman, Matthew A.; Murphy, Andrew J.; Yancopoulos, George D.
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2019-06-19100
OAAI
Crawford, Alison; Haber, Lauric; Kelly, Marcus P.; Vazzana, Kristin; Canova, Lauren; Ram, Priyanka; Pawashe, Arpita; Finney, Jennifer; Jalal, Sumreen; Chiu, Danica; Colleton, Curtis A.; Garnova, Elena; Makonnen, Sosina; Hickey, Carlos; Krueger, Pamela; DelFino, Frank; Potocky, Terra; Kuhnert, Jessica; Godin, Stephen; Retter, Marc W.; Duramad, Paurene; MacDonald, Douglas; Olson, William C.; Fairhurst, Jeanette; Huang, Tammy; Martin, Joel; Lin, John C.; Smith, Eric; Thurston, Gavin; Kirshner, Jessica R.
Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids

可裂解的氨基烷基和芳基类美登素的抗体药物结合物

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2018-05-0121
PREAI
Nittoli, Thomas; Kelly, Marcus P.; Delfino, Frank; Rudge, John; Kunz, Arthur; Markotan, Thomas; Spink, Jan; Chen, Zhaoyuan; Shan, Jing; Navarro, Elizabeth; Tait, Michele; Provoncha, Kathleen; Giurleo, Jason; Zhao, Feng; Jiang, Xiaobo; Hylton, Donna; Makonnen, Sosina; Hickey, Carlos; Kirshner, Jessica R.; Thurston, Gavin; Papadopoulos, Nicholas
Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-07-0423
OAAI
Kelly, Marcus P.; Hickey, Carlos; Makonnen, Sosina; Coetzee, Sandra; Jalal, Sumreen; Wang, Yu; Delfino, Frank; Shan, Jing; Potocky, Terra B.; Chatterjee, Ishita; Andreev, Julian; Kunz, Arthur; D'Souza, Christopher; Giurleo, Jason T.; Nittoli, Thomas; Trail, Pamela A.; Thurston, Gavin; Kirshner, Jessica R.
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys
SCIENTIFIC REPORTS
IF3.9
2015-12-11195
OAAI
Smith, Eric J.; Olson, Kara; Haber, Lauric J.; Varghese, Bindu; Duramad, Paurene; Tustian, Andrew D.; Oyejide, Adelekan; Kirshner, Jessica R.; Canova, Lauren; Menon, Jayanthi; Principio, Jennifer; MacDonald, Douglas; Kantrowitz, Joel; Papadopoulos, Nicholas; Stahl, Neil; Yancopoulos, George D.; Thurston, Gavin; Davis, Samuel

研究方向

暂未获取到该数据
G
Gavin Thurston
H 指数:79论文数:489被引数:3.0万
M
Marcus P. Kelly
H 指数:17论文数:72被引数:1,120
W
William C. Olson
H 指数:58论文数:379被引数:1.4万
C
Carlos Hickey
H 指数:9论文数:61被引数:467
F
Frank J. Delfino
H 指数:20论文数:103被引数:1,344
J
John Lin
H 指数:33论文数:116被引数:4,052
S
Sosina Makonnen
H 指数:14论文数:57被引数:1,087
D
David J. DiLillo
H 指数:33论文数:77被引数:8,228
D
Douglas MacDonald
H 指数:25论文数:68被引数:2,688
L
Lauric Haber
H 指数:11论文数:23被引数:1,310