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High-definition spatial transcriptomics for in situ tissue profiling
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DOI：10.1038/s41592-019-0548-y.png)
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Abstract
En 中文
Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcriptcoupled spatial barcodes at 2-mu m resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.
Keywords:
GENOME-WIDE EXPRESSION
GENE-EXPRESSION
SINGLE
CELLS
SEQ
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