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SaveModulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency
Ma, Yuntao; Josa-Prado, Fernando; Essif, Jacob Nathaniel; Liu, Shuqi; Li, Shuo; Lucena-Agell, Daniel; Chan, Peter YW.; Goossens, Kenneth; Hortiguela, Rafael; Matesanz, Ruth; Wang, Yingjie; Gago, Federico; Wang, Hongbo; Risinger, April; Diaz, J. Fernando; Fang, Wei-Shuo Share Save Share Save Structural insight into the stabilization of microtubules by taxanesProta, Andrea E.; Lucena-Agell, Daniel; Ma, Yuntao; Estevez-Gallego, Juan; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Muhlethaler, Tobias; Gago, Federico; Oliva, Maria A.; Steinmetz, Michel O.; Fang, Wei-Shuo; Diaz, J. Fernando Share Save Share Save Share Save Share Save Taxanes convert regions of perturbed microtubule growth into rescue sitesRai, Ankit; Liu, Tianyang; Glauser, Simon; Katrukha, Eugene A.; Estevez-Gallego, Juan; Rodriguez-Garcia, Ruddi; Fang, Wei-Shuo; Diaz, J. Fernando; Steinmetz, Michel O.; Altmann, Karl-Heinz; Kapitein, Lukas C.; Moores, Carolyn A.; Akhmanova, Anna Share Save Share Save A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water SolubilityMa, Yun-Tao; Yang, Yanting; Cai, Pei; Sun, De-Yang; Sanchez-Murcia, Pedro A.; Zhang, Xiao-Ying; Jia, Wen-Qiang; Lei, Lei; Guo, Mengqi; Gago, Federico; Wang, Hongbo; Fang, Wei-Shuo Share Save Share Save Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressionsTang, Yong; Rodriguez-Salarichs, Javier; Zhao, Yu; Cai, Pei; Estevez-Gallego, Juan; Balaguer-Perez, Francisco; Redondo Horcajo, Mariano; Lucena-Agell, Daniel; Barasoain, Isabel; Fernando Diaz, J.; Fang, Wei-Shuo Share Save Share Save Share Save Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonistsZhang, Guoning; Liu, Shuainan; Tan, Wenjuan; Verma, Ruchi; Chen, Yuan; Sun, Deyang; Huan, Yi; Jiang, Qian; Wang, Xing; Wang, Na; Xu, Yang; Wong, Chiwai; Shen, Zhufang; Deng, Ruitang; Liu, Jinsong; Zhang, Yanqiao; Fang, Weishuo Share Save Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivoLv, Guangyao; Sun, Dengjun; Zhang, Jingwen; Xie, Xiaoxia; Wu, Xiaoqiong; Fang, Weishuo; Tian, Jingwei; Yan, Chunhong; Wang, Hongbo; Fu, Fenghua Share Save Share Save Share Save High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cellsPera, Benet; Calvo-Vidal, M. Nieves; Ambati, Srikanth; Jordi, Michel; Kahn, Alissa; Diaz, J. Fernando; Fang, Weishuo; Altmann, Karl-Heinz; Cerchietti, Leandro; Moore, Malcolm A. S. Share Save Share Save 
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