Not logged in Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy Davis, Sarah M.; Hildebrand, Samuel; MacMillan, Hannah J.; Monopoli, Kathryn R.; Buchwald, Julianna; Sousa, Jacquelyn; Cooper, David; Ly, Socheata; Echeverria, Dimas; McHugh, Nicholas; Ferguson, Chantal; Coles, Andrew; Hariharan, Vignesh N.; O'Reilly, Daniel; Tang, Qi; Furgal, Raymond; Yamada, Ken; Alterman, Julia F.; Gilbert, James W.; Knox, Emily; Pineda, Yamilett; Weston, Caitlyn N.; Baer, Christina E.; Pai, Athma A.; Khvorova, Anastasia Share Save
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Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease Ferguson, Chantal M.; Hildebrand, Samuel; Godinho, Bruno M. D. C.; Buchwald, Julianna; Echeverria, Dimas; Coles, Andrew; Grigorenko, Anastasia; Vangjeli, Lorenc; Sousa, Jacquelyn; McHugh, Nicholas; Hassler, Matthew; Santarelli, Francesco; Heneka, Michael T.; Rogaev, Evgeny; Khvorova, Anastasia Share Save
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Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains Ly, Socheata; Didiot, Marie-Cecile; Ferguson, Chantal M.; Coles, Andrew H.; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia Share Save
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs Godinho, Bruno M. D. C.; Knox, Emily G.; Hildebrand, Samuel; Gilbert, James W.; Echeverria, Dimas; Kennedy, Zachary; Haraszti, Reka A.; Ferguson, Chantal M.; Coles, Andrew H.; Biscans, Annabelle; Caiazzi, Jillian; Alterman, Julia F.; Hassler, Matthew R.; Khvorova, Anastasia Share Save
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset Ferguson, Chantal M.; Godinho, Bruno M. D. C.; Alterman, Julia F.; Coles, Andrew H.; Hassler, Matthew; Echeverria, Dimas; Gilbert, James W.; Knox, Emily G.; Caiazzi, Jillian; Haraszti, Reka A.; King, Robert M.; Taghian, Toloo; Puri, Ajit; Moser, Richard P.; Gounis, Matthew J.; Aronin, Neil; Gray-Edwards, Heather; Khvorova, Anastasia Share Save
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage Borchard, Sabine; Raschke, Stefanie; Zak, Krzysztof M.; Eberhagen, Carola; Einer, Claudia; Weber, Elisabeth; Mueller, Sandra M.; Michalke, Bernhard; Lichtmannegger, Josef; Wieser, Albrecht; Rieder, Tamara; Popowicz, Grzegorz M.; Adamski, Jerzy; Klingenspor, Martin; Coles, Andrew H.; Viana, Ruth; Vendelbo, Mikkel H.; Sandahl, Thomas D.; Schwerdtle, Tanja; Plitz, Thomas; Zischka, Hans Share Save
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system Alterman, Julia F.; Godinho, Bruno M. D. C.; Hassler, Matthew R.; Ferguson, Chantal M.; Echeverria, Dimas; Sapp, Ellen; Haraszti, Reka A.; Coles, Andrew H.; Conroy, Faith; Miller, Rachael; Roux, Loic; Yan, Paul; Knox, Emily G.; Turanov, Anton A.; King, Robert M.; Gernoux, Gwladys; Mueller, Christian; Gray-Edwards, Heather L.; Moser, Richard P.; Bishop, Nina C.; Jaber, Samer M.; Gounis, Matthew J.; Sena-Esteves, Miguel; Pai, Athma A.; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia Share Save
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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways Osborn, Maire F.; Coles, Andrew H.; Biscans, Annabelle; Haraszti, Reka A.; Roux, Loic; Davis, Sarah; Ly, Socheata; Echeverria, Dimas; Hassler, Matthew R.; Godinho, Bruno M. D. C.; Nikon, Mehran; Khvorova, Anastasia Share Save
Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity Haraszti, Reka Agnes; Miller, Rachael; Stoppato, Matteo; Sere, Yves Y.; Coles, Andrew; Didiot, Marie-Cecile; Wollacott, Rachel; Sapp, Ellen; Dubuke, Michelle L.; Li, Xuni; Shaffer, Scott A.; DiFiglia, Marian; Wang, Yang; Aronin, Neil; Khvorova, Anastasia Share Save
RNAi modulation of placental sFLT1 for the treatment of preeclampsia Turanov, Anton A.; Lo, Agnes; Hassler, Matthew R.; Makris, Angela; Ashar-Patel, Ami; Alterman, Julia F.; Coles, Andrew H.; Haraszti, Reka A.; Roux, Loic; Godinho, Bruno M. D. C.; Echeverria, Dimas; Pears, Suzanne; Iliopoulos, Jim; Shanmugalingam, Renuka; Ogle, Robert; Zsengeller, Zsuzsanna K.; Hennessy, Annemarie; Karumanchi, S. Ananth; Moore, Melissa J.; Khvorova, Anastasia Share Save
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier Godinho, Bruno M. D. C.; Henninger, Nils; Bouley, James; Alterman, Julia F.; Haraszti, Reka A.; Gilbert, James W.; Sapp, Ellen; Coles, Andrew H.; Biscans, Annabelle; Nikan, Mehran; Echeverria, Dimas; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia Share Save
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin Didiot, Marie-Cecile; Ferguson, Chantal M.; Ly, Socheata; Coles, Andrew H.; Smith, Abigail O.; Bicknell, Alicia A.; Hall, Lauren M.; Sapp, Ellen; Echeverria, Dimas; Pai, Athma A.; DiFiglia, Marian; Moore, Melissa J.; Hayward, Lawrence J.; Aronin, Neil; Khvorova, Anastasia Share Save
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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo Hassler, Matthew R.; Turanov, Anton A.; Alterman, Julia F.; Haraszti, Reka A.; Coles, Andrew H.; Osborn, Maire F.; Echeverria, Dimas; Nikan, Mehran; Salomon, William E.; Roux, Loic; Godinho, Bruno M. D. C.; Davis, Sarah M.; Morrissey, David V.; Zamore, Phillip D.; Karumanchi, S. Ananth; Moore, Melissa J.; Aronin, Neil; Khvorova, Anastasia Share Save
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay Godinho, Bruno M. D. C.; Gilbert, James W.; Haraszti, Reka A.; Coles, Andrew H.; Biscans, Annabelle; Roux, Loic; Nikan, Mehran; Echeverria, Dimas; Hassler, Matthew; Khvorova, Anastasia Share Save
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Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain Nikan, Mehran; Osborn, Maire F.; Coles, Andrew H.; Biscans, Annabelle; Godinho, Bruno M. D. C.; Haraszti, Reka A.; Sapp, Ellen; Echeverria, Dimas; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia Share Save
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