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pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography Purohit, Vatsal; Steussy, Calvin N.; Rosales, Anthony R.; Critchelow, Chandra J.; Schmidt, Tim; Helquist, Paul; Wiest, Olaf; Mesecar, Andrew; Cohen, Aina E.; V. Stauffacher, Cynthia Share Save
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors Ghosh, Arun K.; Yadav, Monika; Iddum, Satyanarayana; Ghazi, Somayeh; Lendy, Emma K.; Jayashankar, Uttara; Beechboard, Sydney N.; Takamatsu, Yuki; Hattori, Shin-ichiro; Aamano, Masayuki; Higashi-Kuwata, Nobuyo; Mitsuya, Hiroaki; Mesecar, Andrew D. Share Save
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease Jesudason, Cynthia D.; Mason, Emily R.; Chu, Shaoyou; Oblak, Adrian L.; Javens-Wolfe, June; Moussaif, Mustapha; Durst, Greg; Hipskind, Philip; Beck, Daniel E.; Dong, Jiajun; Amarasinghe, Ovini; Zhang, Zhong-Yin; Hamdani, Adam K.; Singhal, Kratika; Mesecar, Andrew D.; Souza, Sarah; Jacobson, Marlene; Di Salvo, Jerry; Soni, Disha M.; Kandasamy, Murugesh; Masters, Andrea R.; Quinney, Sara K.; Doolen, Suzanne; Huhe, Hasi; Rizzo, Stacey J. Sukoff; Lamb, Bruce T.; Palkowitz, Alan D.; Richardson, Timothy I. Share Save
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Genetic variants of phospholipase C-g2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease Tsai, Andy P.; Dong, Chuanpeng; Lin, Peter Bor-Chian; Oblak, Adrian L.; Di Prisco, Gonzalo Viana; Wang, Nian; Hajicek, Nicole; Carr, Adam J.; Lendy, Emma K.; Hahn, Oliver; Atkins, Micaiah; Foltz, Aulden G.; Patel, Jheel; Xu, Guixiang; Moutinho, Miguel; Sondek, John; Zhang, Qisheng; Mesecar, Andrew D.; Liu, Yunlong; Atwood, Brady K.; Wyss-Coray, Tony; Nho, Kwangsik; Bissel, Stephanie J.; Lamb, Bruce T.; Landreth, Gary E. Share Save
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor Bose, Sucharita; Steussy, C. Nicklaus; Lopez-Perez, Daneli; Schmidt, Tim; Kulathunga, Samadhi C.; Seleem, Mohamed N.; Lipton, Mark; Mesecar, Andrew D.; Rodwell, Victor W.; Stauffacher, Cynthia V. Share Save
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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19 Boras, Britton; Jones, Rhys M.; Anson, Brandon J.; Arenson, Dan; Aschenbrenner, Lisa; Bakowski, Malina A.; Beutler, Nathan; Binder, Joseph; Chen, Emily; Eng, Heather; Hammond, Holly; Hammond, Jennifer; Haupt, Robert E.; Hoffman, Robert; Kadar, Eugene P.; Kania, Rob; Kimoto, Emi; Kirkpatrick, Melanie G.; Lanyon, Lorraine; Lendy, Emma K.; Lillis, Jonathan R.; Logue, James; Luthra, Suman A.; Ma, Chunlong; Mason, Stephen W.; McGrath, Marisa E.; Noell, Stephen; Obach, R. Scott; O' Brien, Matthew N.; O'Connor, Rebecca; Ogilvie, Kevin; Owen, Dafydd; Pettersson, Martin; Reese, Matthew R.; Rogers, Thomas F.; Rosales, Romel; Rossulek, Michelle I.; Sathish, Jean G.; Shirai, Norimitsu; Steppan, Claire; Ticehurst, Martyn; Updyke, Lawrence W.; Weston, Stuart; Zhu, Yuao; White, Kris M.; Garcia-Sastre, Adolfo; Wang, Jun; Chatterjee, Arnab K.; Mesecar, Andrew D.; Frieman, Matthew B.; Anderson, Annaliesa S.; Allerton, Charlotte Share Save
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors Ghosh, Arun K.; Shahabi, Dana; Yadav, Monika; Kovela, Satish; Anson, Brandon J.; Lendy, Emma K.; Bonham, Connie; Sirohi, Devika; Brito-Sierra, Carlos A.; Hattori, Shin-Ichiro; Kuhn, Richard; Mitsuya, Hiroaki; Mesecar, Andrew D. Share Save
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies Ghosh, Arun K.; Raghavaiah, Jakka; Shahabi, Dana; Yadav, Monika; Anson, Brandon J.; Lendy, Emma K.; Hattori, Shin-ichiro; Higashi-Kuwata, Nobuyo; Mitsuya, Hiroaki; Mesecar, Andrew D. Share Save
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Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit Hall, Matthew D.; Anderson, James M.; Anderson, Annaliesa; Baker, David; Bradner, Jay; Brimacombe, Kyle R.; Campbell, Elizabeth A.; Corbett, Kizzmekia S.; Carter, Kara; Cherry, Sara; Chiang, Lillian; Cihlar, Tomas; de Wit, Emmie; Denison, Mark; Disney, Matthew; Fletcher, Courtney, V; Ford-Scheimer, Stephanie L.; Gotte, Matthias; Grossman, Abigail C.; Hayden, Frederick G.; Hazuda, Daria J.; Lanteri, Charlotte A.; Marston, Hilary; Mesecar, Andrew D.; Moore, Stephanie; Nwankwo, Jennifer O.; O'Rear, Jules; Painter, George; Saikatendu, Kumar Singh; Schiffer, Celia A.; Sheahan, Timothy P.; Shi, Pei-Yong; Smyth, Hugh D.; Sofia, Michael J.; Weetall, Marla; Weller, Sandra K.; Whitley, Richard; Fauci, Anthony S.; Austin, Christopher P.; Collins, Francis S.; Conley, Anthony J.; Davis, Mindy, I Share Save
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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication Hattori, Shin-ichiro; Higashi-Kuwata, Nobuyo; Hayashi, Hironori; Allu, Srinivasa Rao; Raghavaiah, Jakka; Bulut, Haydar; Das, Debananda; Anson, Brandon J.; Lendy, Emma K.; Takamatsu, Yuki; Takamune, Nobutoki; Kishimoto, Naoki; Murayama, Kazutaka; Hasegawa, Kazuya; Li, Mi; Davis, David A.; Kodama, Eiichi N.; Yarchoan, Robert; Wlodawer, Alexander; Misumi, Shogo; Mesecar, Andrew D.; Ghosh, Arun K.; Mitsuya, Hiroaki Share Save
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