Not logged in Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W. Brad; Watt, Andrew T.; Migawa, Michael T.; Swayze, Eric E.; Prakash, Thazha P. Share Save
Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice Yang, Ya-Wen; Poudel, Bibek; Frederick, Julia; Dhillon, Poonam; Shrestha, Rojesh; Ma, Ziyuan; Wu, Junnan; Okamoto, Koji; Kopp, Jeffrey B.; Booten, Sheri L.; Gattis, Danielle; Watt, Andrew T.; Palmer, Matthew; Aghajan, Mariam; Susztak, Katalin Share Save
Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer Revenko, Alexey; Carnevalli, Larissa S.; Sinclair, Charles; Johnson, Ben; Peter, Alison; Taylor, Molly; Hettrick, Lisa; Chapman, Melissa; Klein, Stephanie; Solanki, Anisha; Gattis, Danielle; Watt, Andrew; Hughes, Adina M.; Magiera, Lukasz; Kar, Gozde; Ireland, Lucy; Mele, Deanna A.; Sah, Vasu; Singh, Maneesh; Walton, Josephine; Mairesse, Maelle; King, Matthew; Edbrooke, Mark; Lyne, Paul; Barry, Simon T.; Fawell, Stephen; Goldberg, Frederick W.; MacLeod, A. Robert Share Save
Share Save
Identification and functional characterization of prognostic long non coding RNA LADDER in lung cancer Narayanan, Sathiya Pandi; Shukla, Sudhanshu; Tien, Jean; Shah, Palak; Shankar, Sunita; Pitchaiya, Sethuramasundaram; Srinivasan, Srihari; Zhang, Yuping; Wang, Xiaoming; Xiao, Lanbo; Cao, Xuhong; Freier, Susan; Watt, Andrew; Guo, Shuling; Feng, Felix; Beer, David; Dhanasekaran, Saravana M.; Chinnaiyan, Arul M. Share Save
Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice Aghajan, Mariam; Booten, Sheri L.; Althage, Magnus; Hart, Christopher E.; Ericsson, Anette; Maxvall, Ingela; Ochaba, Joseph; Menschik-Lundin, Angela; Hartleib, Judith; Kuntz, Steven; Gattis, Danielle; Ahlstrom, Christine; Watt, Andrew T.; Engelhardt, Jeffery A.; Monia, Brett P.; Magnone, Maria Chiara; Guo, Shuling Share Save
High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T-cells and produce antitumor effects in syngeneic tumor models Sinclair, Charles; Revenko, Alexey S.; Peter, Alison; Johnson, Robert B.; Hettrick, Lisa A.; Taylor, Molly; Staniszewska, Anna; Hughes, Adina; Sandin, Lisa; Klein, Stephanie; Watt, Andrew; Barry, Simon; Monia, Brett T.; Lyne, Paul; Macleod, A. Robert; Edbrooke, Mark Share Save
Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression Zhang, Yajia; Pitchiaya, Sethuramasundaram; Cieslik, Marcin; Niknafs, Yashar S.; Tien, Jean C. -Y.; Hosono, Yasuyuki; Iyer, Matthew K.; Yazdani, Sahr; Subramaniam, Shruthi; Shukla, Sudhanshu K.; Jiang, Xia; Wang, Lisha; Liu, Tzu-Ying; Uhl, Michael; Gawronski, Alexander R.; Qiao, Yuanyuan; Xiao, Lanbo; Dhanasekaran, Saravana M.; Juckette, Kristin M.; Kunju, Lakshmi P.; Cao, Xuhong; Patel, Utsav; Batish, Mona; Shukla, Girish C.; Paulsen, Michelle T.; Ljungman, Mats; Jiang, Hui; Mehra, Rohit; Backofen, Rolf; Sahinalp, Cenk S.; Freier, Susan M.; Watt, Andrew T.; Guo, Shuling; Wei, John T.; Feng, Felix Y.; Malik, Rohit; Chinnaiyan, Arul M. Share Save
Serine/Threonine Protein Kinase 25 Antisense Oligonucleotide Treatment Reverses Glucose Intolerance, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Mice Nunez-Duran, Esther; Aghajan, Mariam; Amrutkar, Manoj; Sutt, Silva; Cansby, Emmelie; Booten, Sheri L.; Watt, Andrew; Stahlman, Marcus; Stefan, Norbert; Haering, Hans-Ulrich; Staiger, Harald; Boren, Jan; Marschall, Hanns-Ulrich; Mahlapuu, Margit Share Save
Share Save
In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides Southwell, Amber L.; Skotte, Niels H.; Kordasiewicz, Holly B.; Ostergaard, Michael E.; Watt, Andrew T.; Carroll, Jeffrey B.; Doty, Crystal N.; Villanueva, Erika B.; Petoukhov, Eugenia; Vaid, Kuljeet; Xie, Yuanyun; Freier, Susan M.; Swayze, Eric E.; Seth, Punit P.; Bennett, Clarence Frank; Hayden, Michael R. Share Save
Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice Guo, Shuling; Booten, Sheri L.; Aghajan, Mariam; Hung, Gene; Zhao, Chenguang; Blomenkamp, Keith; Gattis, Danielle; Watt, Andrew; Freier, Susan M.; Teckman, Jeffery H.; McCaleb, Michael L.; Monia, Brett P. Share Save
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration Lagier-Tourenne, Clotilde; Baughn, Michael; Rigo, Frank; Sun, Shuying; Liu, Patrick; Li, Hai-Ri; Jiang, Jie; Watt, Andrew T.; Chun, Seung; Katz, Melanie; Qiu, Jinsong; Sun, Ying; Ling, Shuo-Chien; Zhu, Qiang; Polymenidou, Magdalini; Drenner, Kevin; Artates, Jonathan W.; McAlonis-Downes, Melissa; Markmiller, Sebastian; Hutt, Kasey R.; Pizzo, Donald P.; Cady, Janet; Harms, Matthew B.; Baloh, Robert H.; Vandenberg, Scott R.; Yeo, Gene W.; Fu, Xiang-Dong; Bennett, C. Frank; Cleveland, Don W.; Ravits, John Share Save
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS Ostergaard, Michael E.; Southwell, Amber L.; Kordasiewicz, Holly; Watt, Andrew T.; Skotte, Niels H.; Doty, Crystal N.; Vaid, Kuljeet; Villanueva, Erika B.; Swayze, Eric E.; Bennett, C. Frank; Hayden, Michael R.; Seth, Punit P. Share Save
Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides Egli, Martin; Pallan, Pradeep S.; Allerson, Charles R.; Prakash, Thazha P.; Berdeja, Andres; Yu, Jinghua; Lee, Sam; Watt, Andrew; Gaus, Hans; Bhat, Balkrishen; Swayze, Eric E.; Seth, Punit P. Share Save
Share Save
Share Save
An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA Seth, Punit P.; Allerson, Charles R.; Berdeja, Andres; Siwkowski, Andrew; Pallan, Pradeep S.; Gaus, Hans; Prakash, Thazha P.; Watt, Andrew T.; Egli, Martin; Swayze, Eric E. Share Save
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation Tripathi, Vidisha; Ellis, Jonathan D.; Shen, Zhen; Song, David Y.; Pan, Qun; Watt, Andrew T.; Freier, Susan M.; Bennett, C. Frank; Sharma, Alok; Bubulya, Paula A.; Blencowe, Benjamin J.; Prasanth, Supriya G.; Prasanth, Kannanganattu V. Share Save
Antisense oligonucleotide inhibition of Bcl-xL and bid expression in liver regulates responses in a mouse model of Fas-induced fulminant hepatitis Zhang, H; Taylor, J; Luther, D; Johnston, J; Murray, S; Wyatt, JR; Watt, AT; Koo, S; York-Defalco, C; Stecker, K; Dean, NM Share Save
.png){kind=icon}
.png){kind=icon}
Not logged in.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
