Not logged in High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression Poirson, Juline; Suarez, Irina Paula; Straub, Marie-Laure; Cousido-Siah, Alexandra; Peixoto, Paul; Hervouet, Eric; Foster, Anne; Mitschler, Andre; Mukobo, Noella; Chebaro, Yassmine; Garcin, Dominique; Recberlik, Sevda; Gaiddon, Christian; Altschuh, Daniele; Nomine, Yves; Podjarny, Alberto; Trave, Gilles; Masson, Murielle Share Save
Conformational editing of intrinsically disordered protein by α-methylation Bauer, Valentin; Schmidtgall, Boris; Gogl, Gergo; Dolenc, Jozica; Osz, Judit; Nomine, Yves; Kostmann, Camille; Cousido-Siah, Alexandra; Mitschler, Andre; Rochel, Natacha; Trave, Gilles; Kieffer, Bruno; Torbeev, Vladimir Share Save
Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II Van Zandt, Michael C.; Jagdmann, G. Erik; Whitehouse, Darren L.; Ji, Minkoo; Savoy, Jennifer; Potapova, Olga; Cousido-Siah, Alexandra; Mitschler, Andre; Howard, Eduardo I.; Pyle, Anna Marie; Podjarny, Alberto D. Share Save
Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase Crespo, Isidro; Gimenez-Dejoz, Joan; Porte, Sergio; Cousido-Siah, Alexandra; Mitschler, Andre; Podjarny, Alberto; Pratsinis, Harris; Kletsas, Dimitris; Pares, Xavier; Ruiz, Francesc X.; Metwally, Kamel; Farres, Jaume Share Save
Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma Mazur, Marzena; Olczak, Jacek; Olejniczak, Sylwia; Koralewski, Robert; Czestkowski, Wojciech; Jedrzejczak, Anna; Golab, Jakub; Dzwonek, Karolina; Dymek, Barbara; Sklepkiewicz, Piotr L.; Zagozdzon, Agnieszka; Noonan, Tom; Mahboubi, Keyvan; Conway, Bruce; Sheeler, Ryan; Beckett, Paul; Hungerford, William M.; Podjarny, Alberto; Mitschler, Andre; Cousido-Siah, Alexandra; Fadel, Firas; Golebiowski, Adam Share Save
Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants Noguera, Martin E.; Vazquez, Diego S.; Ferrer-Sueta, Gerardo; Agudelo, William A.; Howard, Eduardo; Rasia, Rodolfo M.; Manta, Bruno; Cousido-Siah, Alexandra; Mitschler, Andre; Podjarny, Alberto; Santos, Javier Share Save
IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors Cousido-Siah, Alexandra; Ruiz, Francesc X.; Fanfrlik, Jindrich; Gimenez-Dejoz, Joan; Mitschler, Andre; Kamlar, Martin; Vesely, Jan; Ajani, Haresh; Pares, Xavier; Farres, Jaume; Hobza, Pavel; Podjarny, Alberto D. Share Save
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Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10 Ruiz, Francesc X.; Cousido-Siah, Alexandra; Porte, Sergio; Dominguez, Marta; Crespo, Isidro; Rechlin, Chris; Mitschler, Andre; de Lera, Angel R.; Jesus Martin, Maria; Angel de la Fuente, Jesus; Klebe, Gerhard; Pares, Xavier; Farres, Jaume; Podjarny, Alberto Share Save
The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition Fanfrlik, Jindrich; Ruiz, Francesc X.; Kadlcikova, Aneta; Rezac, Jan; Cousido-Siah, Alexandra; Mitschler, Andre; Haldar, Susanta; Lepsik, Martin; Kolar, Michal H.; Majer, Pavel; Podjarny, Alberto D.; Hobza, Pavel Share Save
Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning Fanfrlik, Jindrich; Kolar, Michal; Kamlar, Martin; Hurny, David; Ruiz, Francesc X.; Cousido-Siah, Alexandra; Mitschler, Andre; Rezac, Jan; Munusamy, Elango; Lepsik, Martin; Matejicek, Pavel; Vesely, Jan; Podjarny, Alberto; Hobza, Pavel Share Save
Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10 Klein, Fabrice A. C.; Zeder-Lutz, Gabrielle; Cousido-Siah, Alexandra; Mitschler, Andre; Katz, Aline; Eberling, Pascal; Mandel, Jean-Louis; Podjarny, Alberto; Trottier, Yvon Share Save
Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury Van Zandt, Michael C.; Whitehouse, Darren L.; Golebiowski, Adam; Ji, Min Koo; Zhang, Mingbao; Beckett, R. Paul; Jagdmann, G. Erik; Ryder, Todd R.; Sheeler, Ryan; Andreoli, Monica; Conway, Bruce; Mahboubi, Keyvan; D'Angelo, Gerard; Mitschler, Andre; Cousido-Siah, Alexandra; Ruiz, Francesc X.; Howard, Eduardo I.; Podjarny, Alberto D.; Schroeter, Hagen Share Save
Crystal packing modifies ligand binding affinity: The case of aldose reductase Cousido-Siah, Alexandra; Petrova, Tatiana; Hazemann, Isabelle; Mitschler, Andre; Ruiz, Francesc X.; Howard, Eduardo; Ginell, Stephan; Atmanene, Cedric; Van Dorsselaer, Alain; Sanglier-Cianferani, Sarah; Joachimiak, Andrzej; Podjarny, Alberto Share Save
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Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase Blakeley, Matthew P.; Ruiz, Federico; Cachau, Raul; Hazemann, Isabelle; Meilleur, Flora; Mitschler, Andre; Ginell, Stephan; Afonine, Pavel; Ventura, Oscar N.; Cousido-Siah, Alexandra; Haertlein, Michael; Joachimiak, Andrzej; Myles, Dean; Podjarny, Alberto Share Save
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: Structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex Petrova, T; Steuber, H; Hazemann, I; Cousido-Siah, A; Mitschler, A; Chung, R; Oka, M; Icebe, G; El-Kabbani, O; Joachimiak, A; Podjarny, A Share Save
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Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (Lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications Van Zandt, MC; Jones, ML; Gunn, DE; Geraci, LS; Jones, JH; Sawicki, DR; Sredy, J; Jacot, JL; DiCioccio, AT; Petrova, T; Mitschler, A; Podjarny, AD Share Save
Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications Van Zandt, MC; Sibley, EO; McCann, EE; Combs, KJ; Flam, B; Sawicki, DR; Sabetta, A; Carrington, A; Sredy, J; Howard, E; Mitschler, A; Podjarny, AD Share Save
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