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刘

刘新泳 (Xinyong Liu)

shandong university

54H-index
421Paper Count
1.2WCitation Count
Published Papers 287
Publication Date
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Discovery of piperazine-based multi-site occupying coronavirus M<sup>pro</sup> inhibitors with potent and broad-spectrum antiviral activity
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-08-22
err0
PREAI
errBing Ye; Myoungkyu Lee; Letian Song; Yeon Seo Jeon; Mei Wang; Xianghan Bai; Shenghua Gao; Meehyein Kim; Peng Zhan; Xinyong Liu
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Novel Mechanisms of SARS-CoV-2 Drug Resistance and Rational Design of Anti-Resistant Antivirals
errMolecules
IF4.6
err2026-08-01
err0
errOAAI
errXianghan Bai; Bing Ye; Shenghua Gao; Peng Zhan; Xinyong Liu
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errSave
Pyridoimidazolyl Sulfonamide Compound 2: A Superior Dual-Acting Drug Candidate with Potent URAT1 Inhibition and Anti-Inflammatory Activity for Gout Management
errJournal of Medicinal Chemistry
IF6.8
err2026-05-26
err0
PREAI
errXiaoyu Shi; Cheng Shi; Mingyu Yang; Zeqi Yu; Qian Yang; Zhenming Liu; Jianxin Pang; Peng Zhan; Xinyong Liu; Tong Zhao
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Discovery of a Novel Thienopyrimidine Derivative as a Potent Dual URAT1/GLUT9 Inhibitor with Enhanced Urate-Lowering Efficacy; Superior Pharmacokinetics; and Favorable Safety Profile for Gout and Hyperuricemia
errJournal of Medicinal Chemistry
IF6.8
err2026-05-06
err0
PREAI
errQian Yang; Danhui Qi; Wenjie Ye; Xiaoyu Shi; Mingyu Yang; Ting Wu; Zhenkun Wu; Yuexin Xu; Youzhao Wang; Shujing Xu; Zhenqian Wang; Shenghua Gao; Fan Yi; Jianxin Pang; Xinyong Liu; Peng Zhan
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A Novel Pyrrole Acylsulfonamide; Compound 42; as a Dual URAT1/GLUT9 Inhibitor: Potent Urate-Lowering Efficacy; Reduced Off-Target Effects; and Promising Druggability for Hyperuricemia
errJournal of Medicinal Chemistry
IF6.8
err2026-04-17
err0
PREAI
errZhenqian Wang; Xiaoyu Shi; Zitao Guo; Zhenkun Wu; Yuexin Xu; Mingyu Yang; Mei Wang; Qian Yang; Ting Wu; Jianxin Pang; Fan Yi; Peng Zhan; Xinyong Liu
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Recent Advances of Non-Nucleoside Polymerase Inhibitors With Broad-Spectrum Antiviral Activities
errMedicinal Research Reviews
IF11.6
err2026-03-22
err0
PREAI
errSining Tao; Zhenzhen Zhou; Xin Li; Xian-Wei Wang; Xinyong Liu; Dongwei Kang
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Antiviral drug discovery and development: challenges and future directions
errSignal Transduction and Targeted Therapy
IF52.7
err2026-02-25
err0
errOAAI
errShaoqing Du; Xueping Hu; Ping Li; Shujing Xu; Meehyein Kim; Xinyong Liu; Peng Zhan
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errSave
Research Progress on the Structural Biology of Paramyxovirus Polymerase and Its Inhibitors
errJournal of Medicinal Chemistry
IF6.8
err2026-02-09
err0
PREAI
errJinyuan Wu; Sining Tao; An-chao Ge; Zhongxia Zhou; Dongwei Kang; Xinyong Liu
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Discovery and optimization of 2,3-Dihydroindole derivatives as STING receptor allosteric agonists
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-12-16
err0
PREAI
errYing Liu; Jing Wu; Ni Gao; Lin Zheng; Wenbo Zhang; Fabao Zhao; Bairu Meng; Xinyong Liu; Lanyu Liu; Huajun Zhao; Dongwei Kang
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errSave
Recent Advances in Long-Acting Antiviral Agents: Innovations in Design and Strategies for Extended Duration
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err0
PREAI
errWang, Shuo; Ma, Feiyue; Lindsley, Craig W.; Xu, Shujing; Liu, Xinyong; Zhan, Peng
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errSave
Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err1
PREAI
errJin, Yu; Sun, Yang; Zhao, Shujie; Wang, Shuo; Dou, Yutong; Wang, Kai; Li, Qilan; Tavis, John E.; Wu, Zhuanchang; Zhan, Peng; Liu, Xinyong
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errSave
Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators
errJournal of Medicinal Chemistry
IF6.8
err2025-11-10
err0
PREAI
errMinghui Liang; Yutong Dou; Jian Zhang; Zechun Yang; Yuanyuan Liu; Mei Wang; Yiyan Mao; Lindan Guan; Aixin Li; Yuqing Cai; Yan Wang; Peng Xue; Lei Zhang; Zhuanchang Wu; Xinyong Liu; Peng Zhan; Haiyong Jia
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errSave
Deciphering the HIV reservoir: From epigenetic regulators to RNA-mediated regulation
errChinese Chemical Letters
IF8.9
err2025-10-24
err0
PREAI
errXiaojia Xue; Xiangyi Jiang; Jiaojiao Dai; Xinyong Liu; Eline Pellaers; Debyser Zeger; Peng Zhan
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errSave
Correction to “Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2; 4; 6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles”
errJournal of Medicinal Chemistry
IF6.8
err2025-10-23
err0
errOAAI
errXiangkai Ji; Xiangyi Jiang; Zhen Gao; Heng Gao; Xing Huang; Fabao Zhao; Erik De Clercq; Zhao Wang; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu
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errSave
Construction of a comprehensive water quality assessment framework integrating abiotic indicators, multi-taxonomic biological communities, and machine learning
errJournal of Hydrology
IF6.3
err2025-10-10
err0
PREAI
errTianyi Chen; Qian Chen; Xinzong Xiao; Xuefeng Guo; Fang Guo; Xinyong Liu; Yitao Lv; Nan Xu; Weiling Sun
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errSave
Spatiotemporal evolution characteristics, driving factors, and risk assessment of water quality in long-distance inter-basin water transfer projects during 2015–2023
errJournal of Environmental Management
IF8.4
err2025-10-03
err0
PREAI
errQifan Zhang; Pengfei Wang; Weijun Sun; Zhibing Chang; Jiankui Liang; Xinyong Liu; Guodong Ji
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errSave
Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errJi, Xiangkai; Jiang, Xiangyi; Gao, Heng; Gao, Zhen; De Clercq, Erik; Pannecouque, Christophe; Kang, Dongwei; Zhan, Peng; Liu, Xinyong
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Soil-driven tea quality prediction via lightweight deep learning with rolled tensor representation
errSmart Agricultural Technology
IF5.7
err2025-09-23
err0
errOAAI
errWendou Wu; Guoquan Pei; Bing Zhou; Linnan Yang; Xinyong Liu; Yunmei Wang
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errSave
Discovery of a Baloxavir-Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo
errAdvanced Science
IF14.1
err2025-09-15
err0
errOAAI
errSabina Andreu; Kai Tang; Jiahui Zhou; Gabriel Pino-Peco; Nerea López-Carrobles; Raquel Bello-Morales; Daniel Galdo-Torres; Lina Zhang; Federico Gago; José Antonio López-Guerrero; Xinyong Liu; Peng Zhan; Luis Menéndez-Arias
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Advances in click chemistry for drug discovery and development
errExpert Opinion on Drug Discovery
IF4.9
err2025-08-30
err0
PREAI
errJiaojiao Dai; Xiaojia Xue; Xiangyi Jiang; Xinyong Liu; Peng Zhan
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errSave

Research Directions

抗病毒药物研究HBVHCV计算机辅助合理药物设计抗病毒活性研究HIV-1逆转录酶核苷类药物非核苷类抑制剂研究HIV-1侵入过程病毒gp120吸附抑制剂辅助受体CCR5拮抗剂研究开展基于HIV-1转录过程Tat-TAR相互作用抑制剂的研究整合酶抑制剂研究和多靶点药物研究。同时，开展基于HBV侵入转录和包装过程的非核苷类抗乙肝病毒抑制剂研究开展基于流感病毒神经氨酸酶RNA聚合酶为靶点的抑制剂研究基于SARS-CoV-2复制过程中的RNA聚合酶和主蛋白酶为靶标的核苷类共价以及非共价抑制剂的研究。 2. 基于靶标结构活性片段与药效团模型的抗心脑血管药物抗痛风药物抗老年痴呆药物研究。开展基于片段药效团模型的抗凝血抗血小板凝聚药物的研究开展中药川芎活性成分川芎嗪川芎咔啉碱衍生物的结构修饰及其抗氧化损伤抗凝血抗血栓抗血脂抗缺血等心脑血管活性研究开展基于片段药效团模型的抗痛风药物的研究开展基于靶标结构的抗老年痴呆药物及抗肿瘤药物研究药物活性先导物发现的方法学研究。开展基于优势结构组合化学新技术新颖模块化反应药物先导发现新方法研究创新药物的开发与产业化重点开展具有自主产权的创新药物成药性和产业化研究
Co-authors
Cooperation Journals
E
Erik De Clercq
H-index: 162 · Papers: 4.0K
张莉娜 cover
张莉娜 (Lina Zhang)
H-index: 126 · Papers: 1.7K
T
Thomas A. Steitz
H-index: 120 · Papers: 515
张建 cover
张建 (Jian Zhang)
H-index: 99 · Papers: 1.6K
C
Christa E. Müller
H-index: 94 · Papers: 1.0K
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