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Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal route Groo, Anne-Claire; Curel, Thomas; Malzert-Freon, Aurelie; Seguy, Line; Bento, Ophelie; Corvaisier, Sophie; Culerier, Thomas; Legrand, Romain; Callizot, Noelle; Henriques, Alexandre; Culley, Georgia; Claeysen, Sylvie; Rochais, Christophe; Dallemagne, Patrick Share Save
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease Rochais, Christophe; Lecoutey, Cedric; Lalut, Julien; Davis, Audrey; Duval, Emilie; Gaven, Florence; Largilliere, Stacy; Nee, Gerald; Corvaisier, Sophie; Santos, Jana Sopkova de Oliveira; Since, Marc; Freret, Thomas; Legrand, Romain; Callizot, Noelle; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick Share Save
Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability Lagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Since, Marc; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent Share Save
New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability Lagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent Share Save
In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration Seguy, Line; Daressy, Florian; Lahlil, Sophia; Corvaisier, Sophie; Dumontet, Vincent; Litaudon, Marc; Apel, Cecile; Roussi, Fanny; Wiels, Joelle; Robert, Aude; Groo, Anne-Claire; Malzert-Freon, Aurelie Share Save
Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy Mustiere, Romain; Lagardere, Prisca; Hutter, Sebastien; Dell'Orco, Viviana; Amanzougaghene, Nadia; Tajeri, Shahin; Franetich, Jean-Francois; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Masurier, Nicolas; Lisowski, Vincent; Verhaeghe, Pierre; Mazier, Dominique; Azas, Nadine; Vanelle, Patrice; Primas, Nicolas Share Save
NA1-115-7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes Daressy, Florian; Seguy, Line; Favre, Loetitia; Corvaisier, Sophie; Apel, Cecile; Groo, Anne-Claire; Litaudon, Marc; Dumontet, Vincent; Malzert-Freon, Aurelie; Desrat, Sandy; Roussi, Fanny; Robert, Aude; Wiels, Joelle Share Save
Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore Paoli-Lombardo, Romain; Primas, Nicolas; Bourgeade-Delmas, Sandra; Hutter, Sebastien; Sournia-Saquet, Alix; Boudot, Clotilde; Brenot, Emilie; Castera-Ducros, Caroline; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Courtioux, Bertrand; Valentin, Alexis; Verhaeghe, Pierre; Azas, Nadine; Rathelot, Pascal; Vanelle, Patrice Share Save
Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer's Disease Treatment Seguy, Line; Guyon, Lena; Maurel, Manon; Verdie, Pascal; Davis, Audrey; Corvaisier, Sophie; Lisowski, Vincent; Dallemagne, Patrick; Groo, Anne-Claire; Malzert-Freon, Aurelie Share Save
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer's disease Toublet, Francois-Xavier; Lalut, Julien; Hatat, Berenice; Lecoutey, Cedric; Davis, Audrey; Since, Marc; Corvaisier, Sophie; Freret, Thomas; Santos, Jana Sopkova-de Oliveira; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick; Rochais, Christophe Share Save
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T.b. brucei hitcompound with improved pharmacokinetic properties Fersing, Cyril; Boudot, Clotilde; Paoli-Lombardo, Romain; Primas, Nicolas; Pinault, Emilie; Hutter, Sebastien; Castera-Ducros, Caroline; Kabri, Youssef; Pedron, Julien; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Valentin, Alexis; Azqueta, Amaya; Muruzabal, Damian; Destere, Alexandre; Wyllie, Susan; Fairlamb, Alan H.; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Di Giorgio, Carole; Rathelot, Pascal; Azas, Nadine; Courtioux, Bertrand; Vanelle, Patrice; Verhaeghe, Pierre Share Save
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi Fersing, Cyril; Boudot, Clotilde; Castera-Ducros, Caroline; Pinault, Emilie; Hutter, Sebastien; Paoli-Lombardo, Romain; Primas, Nicolas; Pedron, Julien; Seguy, Line; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Brossas, Jean-Yves; Paris, Luc; Valentin, Alexis; Wyllie, Susan; Fairlamb, Alan H.; Boutet-Robinet, Elisa; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Destere, Alexandre; Mazier, Dominique; Rathelot, Pascal; Courtioux, Bertrand; Azas, Nadine; Verhaeghe, Pierre; Vanelle, Patrice Share Save
Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment Adnet, Thomas; Groo, Anne-Claire; Picard, Celine; Davis, Audrey; Corvaisier, Sophie; Since, Marc; Bounoure, Frederic; Rochais, Christophe; Le Pluart, Loic; Dallemagne, Patrick; Malzert-Freon, Aurelie Share Save
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi Pedron, Julien; Boudot, Clotilde; Brossas, Jean-Yves; Pinault, Emilie; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Boutet-Robinet, Elisa; Destere, Alexandre; Tronnet, Antoine; Berge, Justine; Bonduelle, Colin; Deraeve, Celine; Pratviel, Genevieve; Stigliani, Jean-Luc; Paris, Luc; Mazier, Dominique; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aureprimelie; Wyllie, Susan; Milne, Rachel; Fairlamb, Alan H.; Valentin, Alexis; Courtioux, Bertrand; Verhaeghe, Pierre Share Save
Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes De Pascale, Martina; Iacopetta, Domenico; Since, Marc; Corvaisier, Sophie; Vie, Veronique; Paboeuf, Gilles; Hennequin, Didier; Perato, Serge; De Giorgi, Marcella; Sinicropi, Maria Stefania; Santos, Jana Sopkova-De Oliveira; Voisin-Chiret, Anne-Sophie; Malzert-Freon, Aurelie Share Save
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