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R

Richard B. Silverman

Northwestern University

54H-index
597Paper Count
1.4WCitation Count
Published Papers 246
Publication Date
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Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of γ-Aminobutyric Acids
errJournal of the American Chemical Society
IF15.6
err2026-07-10
err0
PREAI
errFeng Wang; Mary C. Corrigan; Nhat Hoang Van Le; Dorothy Duan; Corine O. Smith; Graham R. Moran; Neil L. Kelleher; Dali Liu; Richard B. Silverman
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Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator
errJournal of the American Chemical Society
IF15.6
err2026-02-19
err0
PREAI
errKoon Mook Kang; Abigail L. Vargas; Luana Assis Ferreira; Benjamin James Des Soye; Mary Corrigan; Cathy Kexin Zhang; Feng Wang; Dorothy Duan; Neil L. Kelleher; Andrea G. Hohmann; Dali Liu; Richard B. Silverman
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Enhancement of Potency and Selectivity of 2-Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors
errJournal of Medicinal Chemistry
IF6.8
err2026-02-04
err0
PREAI
errAnas Ansari; Koon Mook Kang; Huiying Li; Christine D. Hardy; Athri D. Rathnayake; Amardeep Awasthi; Thomas L. Poulos; Richard B. Silverman
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Potent; Selective; and Brain Penetrant Ether-Linked 2-Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase with Excellent Oral Bioavailability
errJournal of Medicinal Chemistry
IF6.8
err2026-02-02
err0
PREAI
errAnas Ansari; Radoslaw T. Chrzanowski; Huiying Li; Christine D. Hardy; Amardeep Awasthi; Thomas L. Poulos; Richard B. Silverman
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New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma
errJournal of Medicinal Chemistry
IF6.8
err2026-01-30
err0
errOAAI
errAmardeep Awasthi; Anika Patel; Huiying Li; Koon Mook Kang; Christine D. Hardy; Anas Ansari; Raghad Nowar; Md. Emtiaz Hasan; Sun Yang; Thomas L. Poulos; Richard B. Silverman
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Identification of a glia-associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU-9
errALZHEIMERS & DEMENTIA
IF11.1
err2025-12-18
err0
errOAAI
errKranz, Daniel L.; de Leon Velez, Omar; Ulupinar, Emel; Ozdinler, P. Hande; Silverman, Richard B.; Klein, William L.
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Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis
errBioorganic Chemistry
IF4.7
err2025-11-02
err0
PREAI
errMohamed F. Elmansy; Pedro Soares; Jose Ricardo D. dos Remedios; Raghad Nowar; Susan G. Fox; Anan Yu; William L. Klein; Richard I. Morimoto; Richard B. Silverman
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Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2025-07-01
err0
PREAI
errVasu, Dhananjayan; Do, Ha T.; Li, Huiying; Hardy, Christine D.; Poulos, Thomas L.; Silverman, Richard B.
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A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with an Unprecedented Binding Mode
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-03-01
err0
PREAI
errWeerawarna, Pathum M.; Li, Huiying; Rathnayake, Athri D.; Hardy, Christine D.; Poulos, Thomas L.; Silverman, Richard B.
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Crosstalk Between nNOS/NO and COX-2 Enhances Interferon-Gamma-Stimulated Melanoma Progression
errCANCERS
IF4.4
err2025-01-31
err0
errOAAI
errPatel, Anika; Tong, Shirley; Roosan, Moom R.; Syed, Basir; Awasthi, Amardeep; Silverman, Richard B.; Yang, Sun
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Protection against Amyloid-β Aggregation and Ferroptosis/Oxytosis Toxicity by Arylpyrazolones: Alzheimer's Disease Therapeutics
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-01-24
err0
PREAI
errSoares, Pedro; Rahaman, Mizzanoor; Maher, Pamela; Silverman, Richard B.
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Synthesis of Oxabicyclo[3.2.1]octan-3-ol Scaffold via Burgess Reagent Mediated Cyclodehydration of δ-Diols under Acidic Conditions
errORGANIC LETTERS
IF5
err2025-01-06
err0
PREAI
errElmansy, Mohamed F.; dos Remedios, Jose Ricardo D.; Silverman, Richard B.
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Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-12-30
err0
PREAI
errWirt, Jonah L.; Ferreira, Luana Assis; Jesus, Carlos Henrique Alves; Woodward, Taylor J.; Oliva, Idaira; Xu, Zhili; Crystal, Jonathon D.; Pepin, Robert H.; Silverman, Richard B.
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Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase(vol 19,pg 1066,2024)
errACS CHEMICAL BIOLOGY
IF3.8
err2024-07-18
err0
PREAI
errDevitt, Allison N.; Vargas, Abigail L.; Zhu, Wei; Des Soye, Benjamin James; Butun, Fatma Ayaloglu; Alt, Tyler; Kaley, Nicholas; Ferreira, Glaucio M.; Moran, Graham R.; Kelleher, Neil L.; Liu, Dali; Silverman, Richard B.
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Synthesis of (2R,4S)-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2024-06-10
err2
PREAI
errDukes, Adrian O.; Weerawarna, Pathum M.; Devitt, Allison N.; Silverman, Richard B.
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Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase
errACS CHEMICAL BIOLOGY
IF3.8
err2024-04-17
err2
PREAI
errDevitt, Allison N.; Vargas, Abigail L.; Zhu, Wei; Des Soye, Benjamin James; Butun, Fatma Ayaloglu; Alt, Tyler; Kaley, Nicholas; Ferreira, Glaucio M.; Moran, Graham; Kelleher, Neil L.; Liu, Dali; Silverman, Richard B.
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Development of HH044, an orally bioavailable nNOS inhibitor, for the treatment of cutaneous melanoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errPatel, Anika; Tong, Shirley; Silverman, Richard B.; Yang, Sun
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Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis
errACS CENTRAL SCIENCE
IF10.4
err2023-12-20
err0
errOAAI
errWeerawarna, Pathum M.; Schiefer, Isaac T.; Soares, Pedro; Fox, Susan; Morimoto, Richard I.; Melani, Rafael D.; Kelleher, Neil L.; Luan, Chi-Hao; Silverman, Richard B.
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Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-11
err5
PREAI
errVasu, Dhananjayan; Do, Ha T. T.; Li, Huiying; Hardy, Christine D. D.; Awasthi, Amardeep; Poulos, Thomas L. L.; Silverman, Richard B. B.
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Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis
errMEDICINAL RESEARCH REVIEWS
IF11.6
err2023-05-26
err4
errOAAI
errElmansy, Mohamed F.; Reidl, Cory T.; Rahaman, Mizzanoor; Ozdinler, P. Hande; Silverman, Richard B.
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Research Directions

No research directions
Co-authors
Cooperation Journals
K
K. N. Houk
H-index: 157 · Papers: 2.6K
V
Victor Nizet
H-index: 123 · Papers: 871
R
Richard I. Morimoto
H-index: 121 · Papers: 425
王
王华 (Hua Wang)
H-index: 113 · Papers: 1.6K
N
Neil L. Kelleher
H-index: 106 · Papers: 712
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